Immunology 9 - Hypersensitivity disorders (Path Guide) Flashcards Preview

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Flashcards in Immunology 9 - Hypersensitivity disorders (Path Guide) Deck (27)
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1

Against what are antibodies directed in HDN?

Rhesus antigens on neonatal erythrocytes

2

Against what are antibodies directed in autoimmune haemolytic anaemia?

Rh blood group antigens

3

Against what are antibodies directed in ITP?

Glycoprotein IIb/IIIa on platelets

4

Against what are antibodies directed in pemphigus vulgaris?

Epidermal cadherin

5

Against what are antibodies directed in acute rheumatic fever?

M proteins on GAS

6

What tests can be used to diagnosis myasthenia gravis?

Anti nAch-R Ab
Abnormal EMG
Tensilon test

7

How is the tensilon test performed?

Injection of reversible acetylcholine esterase inhibitor
Patient with MG will experience increased strength and endurance with repetitive movements

8

Recall some treatments for myasthenia gravis

Neostigmine
Pyridostigmine

9

How should eosinophilic granulomatosis with polyangiitis be treated?

Corticosteroids
Azathioprine
Cyclophosphamide

10

How should granulomatosis with polyangiitis be treated?

Corticosteroids
Cyclophosphamide
Co-trimoxazole

11

Livedo reticularis is seen in which of the vasculitides?

Microscopic polyangiitis

12

Against what are antibodies directed in mixed essential cryoglobulinaemia?

IgG +/- HepC antigens

13

Recall the symptoms of mixed essential cryoglobulinaemia

Arthralgia
Splenomegaly
Skin, nerve and kidney involvement
Association with Hep C

14

Recall the symptoms of serum sickness

Rashes, pruritis, arthralgia, lymphadenopathy, fever and malaise, 7-12 days following exposure to penicillin

15

How can serum sickness be diagnosed?

Decreased C3
Blood shows immune complexes or signs of blood vessel inflammation

16

Which antigens are involved in polyarteritis nodosa?

Hep B + C viral antigens

17

In what type III hypersensitivity disorder might the 'rosary sign' be seen, and what is this sign?

Polyarteritis nodosa
CT finding showing adenomyosis of the gallbladder - similar to pearl necklace sign

18

Recall the symptoms/signs of SLE

ARMADA SHIPS
Arthritis
Raynaud's/ renal findings
Malar rash
ANA positive
Discoid rash
Apthous ulcers

Serositis
Haematology findings
Immunology (anti-dsDNA, anti-sm)
Photosensitivity
Seizures

19

Recall some drugs that can cause drug-induced SLE

Hydralyzine (hypertension)
Isoniazid (TB)
Procainamide (cardiac arrhythmias)

20

What is the defininitive diagnostic test for MS?

LP --> CSF showing oligoclonal bands of IgG on electrophoresis

21

Recall the pharmacological treatments for MS

Corticosteroids
IFN beta

22

Recall the antibodies involved in Sjogren's syndrome

Anti-Ro
Anti-La

23

Recall the antibodies involved in polymyositis/ dermatomyositis

Anti-Jo-1

24

What are the HLA associations of coeliac?

HLA-DQ2 and DQ8 (two eight or not to eat?)

25

Recall the antibodies involved in autoimmune hepatitis

Anti-smooth muscle
Anti-LKM-1
Anti soluble liver antigen (anti-SLA)

26

What is anti-U1RNP (speckled pattern) associated with?

Mixed connective tissue disease (including SLE)

27

What antibody is involved in primary biliary cirrhosis?

Anti-mitochondrial

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