Microbiology 19 - Influenza and Covid-19 Flashcards Preview

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Flashcards in Microbiology 19 - Influenza and Covid-19 Deck (15)
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1

What drives zoonosis of influenza viruses from wild water fowl?

Antigenic drift

2

What must a mutation change to produce a pandemic-producing virus ?

Transmissibility between humans
Antigenic novelty

3

Recall the process of influenza A cleavage

1. Viral spike proteins (most important is haemaglutinnin - HA)
2. Protease required to cleave HA is only found in airway (Human Airway Tryptase)
3. HAT cleaves influenza A at a specific site

4

What is the mechanism of action of amantidine, and what is it used for?

Targets M2 ion channel
Used to treat strains types of influenza virus

5

What class of drug is oseltamivir?

Neuraminidase inhibitor

6

What is the flu vaccine made up of?

Haemaglutinnin and neuraminidase proteins

7

What is the most important reason why SARS 2003 was so much easier to contain than SARS Covid 19?

Patients had easily-identifiable symptoms that developed quickly and so could be isolated - covid-19 is much more insidious!

8

Describe the genome of SARS-Cov2

Huge single-stranded RNA genome

9

What is Nsp14, and why is it important to the covid genome?

It's a proof-reading exonuclease - which is unusual for an RNA virus

10

How does covid bind to cells to gain entry?

Via ACE2

11

How long after infection is covid infectious?

3 days

12

Recall 2 important factors that will be at elevated serum levels in covid infection, and can be useful clinically?

IL-6
D-dimer

13

What benefit is remdesivir shown to have in coronavirus?

Shortens time to recovery

14

In which patients is dexamethosone effective at reducing coronavirus death?

In those who are receiving oxygen

15

Which monoclonal is being used to treat coronavirus?

Tociluzmab - anti-IL6

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