Haematology 7 - CML Flashcards Preview

Year 5 Pathology ICSM - DM me for full access > Haematology 7 - CML > Flashcards

Flashcards in Haematology 7 - CML Deck (6)
Loading flashcards...
1

How does CML affect the liver and spleen?

Infarction of cords and red pulp (spleen) and hepatic sinusoids (liver) by granulocytes

2

Recall 3 possible symptoms of CML

Lethargy
Bruising
Monocular blindness (due to CVA)

3

In what ways will a blood film be unusual in CML?

Biphasic peak of neutrophils and myelocytes
Raised basophils

4

What investigation can be done to show BCR-ABL

FISH - a fluorescent DNA probe hybridises selectively to a particular chromosome segment

5

What are the phases of CML?

Chronic: 3-4 years
Accelerated: 6-12 months
Blast crisis: 3-6 months

6

What are the 1st, 2nd and 3rd line treatments for CML?

1st. Imatinib
2nd. 2nd/3rd generation TK inhibitor
3rd. allogenic stem cell transplant

Decks in Year 5 Pathology ICSM - DM me for full access Class (85):