Haematology 1 - Acute leukaemia Flashcards Preview

Year 5 Pathology ICSM > Haematology 1 - Acute leukaemia > Flashcards

Flashcards in Haematology 1 - Acute leukaemia Deck (12)
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1

What is the median age of presentation of AML?

65-70

2

Recall some genetic associations of AML

t(15;17)
inv(16)
Trisomy 21
5q deletion
7q deletion

3

Which type of leukaemia is most likely to cause haemorrhage?

Acute Promyelocytic leukaemia (APML)

4

Which type of leukaemia is most likely to cause DIC?

APML

5

What is the key triad of clinical features of AML?

Anaemia
Thrombocytopaenia
Neutropaenia

6

Recall some clinical signs that can be used to identify AML

Hepatosplenomegaly
Monocytic gum infiltration
CNS disease
Occasional lymphadenopathy

7

How can myeloid lineage be proved on blood film?

Presence of auer rods

8

What is the most effective investigation for differentiating AML and ALL, and what results would it show for each?

Immunophenotyping:
AML: CD13/1/15
ALL: CD3/4/18/19/20

9

Recall some useful supportive therapies for AML

Blood products: red cells, platelets and FFP
Antibiotics
Long line
Allopurinol (as uric acid may be released from dying cells when treatment is started)

10

Which type of leukaemia is most likely to present with long bone pain?

ALL

11

Recall some sights of leukaemic involvement in ALL that you wouldnt see in AML

Thymus, testes, CNS

12

Which ALL patients are appropriate for imatinib treatment?

Philadelphia chromosome positive

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