Flashcards in Chemical Pathology 2 - Lipoprotein metabolism, CVD and obesity Deck (22)
What is the role of HDL?
Picks up excess cholesterol from the periphery and transports it to liver
What is the role of the enzyme CETP in cholesterol metabolism?
HDL to VLDL conversion
What is the key enzyme involved in cholesterol synthesis?
HMG CoA reductase
Which enzyme converts cholesterol to cholesteryl ester?
What is VLDL constituted of?
ApoB, cholesteryl ester and triglyceride
What is the function of 7-alpha hydroxase in cholesterol metabolism?
Converts cholesterol to bile acids
What is the main component of mixed micelles?
Where are bile acids resorbed?
What controls the amount of cholesterol resorbed into the intestine?
Balance of 2 enzymes: NPC1L1 and ABC G5/G8
What is the inheritance pattern of familial hypercholesterolaemia type II?
What name is given to an inherited predeliction to high HDL, and what mutation causes this?
Familial hyper alpha lipoproteinaemia
= CETP deficiency
What condition is caused by ABC G5/G8 mutation?
What is phytosterolaemia?
Inherited condition that allows plant sterols to enter the plasma freely, which are more athrogenic than cholesterol itself
Recall 3 clinical signs of hypercholesterolaemia
How can you examine for tendon xanthoma?
Feel back of ACL
What are the different types of primary hypertriglyceridaemia?
I, IV and V
What is A-beta-lipoproteinaemia?
MTP deficiency causing hypolipidaemia
Recall 3 inherited conditions that can cause hypolipidaemia
Tangier disease (HDC deficiency)
What is the effect of statins on cholesterol levels?
Very effective at reducing LDL, also reduce triglyceride and HDL
What is the effect of fibrate drugs on cholesterol levels?
Very effective at reducing triglycerides, also reduces LDL
What is the role of PCSK9?
Binds LDLR and promotes its degradation