Histopathology 16 - Neurodegeneration Flashcards Preview

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Flashcards in Histopathology 16 - Neurodegeneration Deck (11)
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1

Recall 4 histopatological features of a brain with Alzheimer's dementia

Extracellular plaques
Neurofibrillary tangles
Cerebral amyloid angiopathy
Neuronal loss (cerebral atrophy)

2

What does Tau staining show in Alzheimer's disease?

Hyperphosphorylation

3

How is Alzheimer's disease diagnosed at post-mortem?

Tau staining

4

What grading is used to stage Alzheimer's disease at post-mortem?

Braak grading
Pathological changes begin in hippocampus and spread to occipital cortex - degree of spread guides staging

5

What is the basic pathophysiology of Parkinson's disease?

Loss of dopaminergic cells in the substantia nigra, which project onto the striatum to control movement

6

What is the role of Lewy bodies in Parkinson's disease?

Cause a mutation in alpha synuclein

7

What disease are "ballroom neurons" associated with?

Frontotemporal dementia/ Pick's disease

8

Which neurodegenerative disease shows 4R 3R tauopathy?

Alzheimer's dementia

9

Which neurodegenerative disease shows 4R tauopathy?

Progressive supranuclear palsy

10

Which neurodegenerative disease shows 3R tauopathy?

Pick's disease

11

Which neurodegenerative disease can be caused by a progranulin Z mutation?

Frontotemporal dementia (in this case there would be no tau pathology)

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