Haematology 15 - Bone Marrow Transplant Flashcards Preview

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Flashcards in Haematology 15 - Bone Marrow Transplant Deck (9)
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1

Which CD marker is expressed on haematopoietic stem cells?

CD34

2

Recall the process of autologous transplant

1. Give G-CSF - lots of stem cells leak out into the blood
2. Freeze them (drop temp and store in liquid N2)
3. Patient has chemo/radio to permanently destroy their haematopietic system
4. Whip stem cells out of freezer and re-infuse

3

What is autologous stem cell transplant used for?

To allow a higher dose of chemo/radio to be given
Myeloma/ lymphoma/ CLL

4

Describe the process of allogeneic stem cell transplant

Give G-CSF to donor with normal BM
Treat patient with high-dise chemo and radio
Give patient harvested cells

5

When should allogenic stem cell transplant be used?

Bone marrow failure
Any patient where bone marrow can't be cleared (eg acute leukaemias)

6

How is patient's room pressure adjusted to prevent infection during BM transplant?

Make it a higher pressure than corridor so that air flows out rather than in

7

Recall some principles of donor choice for a bone marrow transplant

1. HLA-matched
2. Ideally a sibling (1 in 4 chance of matching with each sibling)

8

Which patients can receive umbilical cord blood cells?

Only children - as you can only harvest a small volume so patient needs to be of a low weight

9

How many types of HLA are there?

>20,000!

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