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Flashcards in Microbiology 6 - GI infections Deck (37)
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1

In a febrile patient with a GI infection, what are the key differentials?

1. Inflammatory diarroea
2. If no diarrhoea - enteric fever (typhoid/ salmonella)

2

In an afebrile patient with a GI infection, what is the top differential?

Secretory diarrhoea due to toxins (eg cholera)

3

What is the incubation period of campylobacter?

1-10 days

4

What is the incubation period of bacilus cereus?

1-6 hours

5

Why does staph aureus food poisoning produce such rapid symptoms?

Toxin is pre-formed

6

What are the key cytokines involved in Staph aureus food poisoning?

IL-7 and IL-2

7

Describe the symptoms of S aureus food poisoning

Vomiting
Waterey, non-bloody diarrhoea

8

Describe the different toxins produced by bacilus cereus

Heat-stable toxin causes emesis
Heat-labile toxin causes diarrhoea
Only the heat-labile toxin is destroyed upon heating

9

Describe the diarrhoea produced by bacilus cereus

Waterey, non-bloody

10

In what type of food might clostridia botulinum be found?

Honey

11

What type of clostridia spp causes food poisoning?

Clostridia perfringens

12

In what sort of food is clostridia perfringens found?

Re-heated meat

13

Which organism causes pseudomembranous colitis?

Clostridium difficile

14

Which diarrhoeal disease is associated with antibiotic use?

Pseudomembranous colitis caused by C. difficile

15

What type of symptoms does listeria monocytogenes poisoning cause?

Febrile gastroenteritis
Waterey diarrhoea

16

Recall 2 sources of listeria poisoning

Unpasteurised dairy
Refringerated foods (eg sandwiches)

17

Is listeria alpha or beta haemolytic?

Beta haemolytic

18

What is the causative organism in 'traveller's diarrhoea'?

Enterobacteriacae (usually the toxogenic form, ETEC)

19

What organism causes haemolytic uraemic syndrome?

EHEC enterobacteriacae

20

Recall one very important thing to avoid in the management of enterobacteriacae poisoning

Antibiotics

21

Recall 3 worrying species of salmonella

S typhi
S enteritidis
S cholerasuis

22

What symptoms are caused by S typhi infection?

Bactaraemia
Constipation and fever
Splenomegaly and ROSE SPOTS

23

What are the 2 key forms of shigella that cause disease in humans?

S dysenteriae
S flexneri (associated with MSM)

24

What disease pattern does shigella infection cause?

Dysentry

25

How should shigella infection be managed?

Avoid antibiotics
If really necessary, go for ciprofloxacin

26

What is the typical stool appearance in Vibrio cholerae infection?

Rice water

27

Which organism is most likely to cause cellulitis in a scuba diver?

Vibrio vulnificus

28

On what sort of agar can vibrio spp be grown?

Salty agar

29

For how long can campylobacter symptoms last?

Up to 20 days

30

What is one key serious complication of campylobacter infection?

Guillan Barre syndrome

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