Histopathology 13 - Histopathology of Systemic Disease Flashcards Preview

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Flashcards in Histopathology 13 - Histopathology of Systemic Disease Deck (14)
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1

What can JCV infection in HIV positive patients lead to?

Progressive multifocal leukoencephalopathy

2

What is the most common opportunistic infection in HIV positive patients?

CMV

3

Which herpes virus causes kaposi sarcoma?

HHV8

4

What is the main histological finding in sarcoidosis?

Non-caseating granulomas

5

How does end-stage sarcoidosis appear on CXR?

'Honeycomb' lung

6

What is a granuloma made up of?

Lymphoid cells and giant cells

7

What colour does IgG4 stain when positive?

Brown

8

Recall 3 diseases caused by IgG4 inflammation

Riedel thyroiditis
Autoimmune pancreatitis
Inflammatory pseudotumours

9

What is the structure of amyloid?

Beta pleated sheet that forms non-branching fibrils

10

What is the cause of AA amyloidosis?

Chronic inflammation

11

Which conditions are particularly implicated in the development of AA amyloidosis?

Crohn's
Rheumatoid arthritis

12

What conditions can cause AL amyloidosis?

Myeloma
B cell neoplasms

13

What is the link between transthyretin and amyloidosis?

Transthyretin mutation can --> cardiac amyloid

14

What stain can be used for amyloid?

Congo red - gives green birefringence under polarised light

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