Flashcards in Microbiology 13 - Opportunistic viral infection Deck (23)
What is the Baltimore classification?
Virus classification system
What class of viruses form latent infections?
How is most viral serology performed?
Recall 3 reasons for immunosuppression
1. Solid organ transplant
2. Human stem cell transplant (short term, or long term if they have significant GVHD)
Recall 4 types of immunosuppressing drugs
2. Calcineurin inhibitors
3. Anti-proliferative agent (eg. Azothioprine/ mycophenolate)
What is the most important opportunistic virus in transplant patients?
What virus causes multifocal leukoencephalopathy?
What is a common re-activator of latent HSV?
What is HHV4?
What is HHV8?
Kaposi's sarcoma associated herpesvirus
What drug would you give to someone who has CMV AND is immunosuppressed?
For which hepatitis viruses are there vaccines?
Hep A and B
Why is adenovirus particularly problematic in post-bone marrow transplant children?
You get disseminated disease
What is the treatment for disseminated adenovirus?
In which patients does JC virus cause PML?
What two conditions can BK virus cause in the immunosuppressed?
What disease does parvovirus cause in a chronically immunosuppressed patient?
In renal transplants, is risk of CMV transmission when the donor or recipient is positive?
Donor is pos
In Human Stem Cell Transplants, is risk of CMV transmission when the donor or recipient is positive?
Donor is neg (recipient is pos) as patient with CMV has immune system replaced with one that is CMV-naive
Describe the pattern of symptoms caused by varicella infection in the immunocompromised
Pneumonitis, encephalitis and hepatitis
In neonate: purpura fulminans
What is the most common malignancy caused by EBV?
Post-transplant lymphoproliferative disorder
What is the most common clinical syndrome caused by CMV infection?