Microbiology 13 - Opportunistic viral infection Flashcards Preview

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Flashcards in Microbiology 13 - Opportunistic viral infection Deck (23)
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1

What is the Baltimore classification?

Virus classification system

2

What class of viruses form latent infections?

DNA viruses

3

How is most viral serology performed?

Indirectc ELISA

4

Recall 3 reasons for immunosuppression

1. Solid organ transplant

2. Human stem cell transplant (short term, or long term if they have significant GVHD)

3. HIV/AIDS

5

Recall 4 types of immunosuppressing drugs

1. Steroids

2. Calcineurin inhibitors

3. Anti-proliferative agent (eg. Azothioprine/ mycophenolate)

4. Antibodies

6

What is the most important opportunistic virus in transplant patients?

CMV

7

What virus causes multifocal leukoencephalopathy?

JC virus

8

What is a common re-activator of latent HSV?

Stressful situations

9

What is HHV4?

EBV

10

What is HHV8?

Kaposi's sarcoma associated herpesvirus

11

What drug would you give to someone who has CMV AND is immunosuppressed?

Valganciclovir

12

For which hepatitis viruses are there vaccines?

Hep A and B

13

Why is adenovirus particularly problematic in post-bone marrow transplant children?

You get disseminated disease

14

What is the treatment for disseminated adenovirus?

Cidofavir

15

In which patients does JC virus cause PML?

AIDS patients

16

What two conditions can BK virus cause in the immunosuppressed?

Haemorrhagic cystitis
Nephropathy

17

What disease does parvovirus cause in a chronically immunosuppressed patient?

Anaemia

18

In renal transplants, is risk of CMV transmission when the donor or recipient is positive?

Donor is pos

19

In Human Stem Cell Transplants, is risk of CMV transmission when the donor or recipient is positive?

Donor is neg (recipient is pos) as patient with CMV has immune system replaced with one that is CMV-naive

20

Describe the pattern of symptoms caused by varicella infection in the immunocompromised

Pneumonitis, encephalitis and hepatitis
In neonate: purpura fulminans

21

What is the most common malignancy caused by EBV?

Post-transplant lymphoproliferative disorder

22

What is the most common clinical syndrome caused by CMV infection?

Retinitis

23

What CMV prophylaxis is offered, and to whom?

Ganciclovir
Given to all transplant patients

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