Flashcards in Haematology 10 - Lymphoma 1: multidisciplinary Deck (44)
What is multiple myeloma a malignancy of?
Why do bacterial infections and autoimmune disorders increase lymphoma risk?
Constant antigenic stimulation
Why do viral infections increase lymphoma risk?
Direct viral integration of lymphocytes
Which lymphoma does Sjorgen's syndrome increase risk of?
Marginal zone lymphoma of the parotid
Which lymphoma does Hashimoto's syndrome increase risk of?
Marginal zone lymphoma of the thyroid
How is HTLV1 transmitted, and which cancer does it increase risk of?
A retrovirus that is transmitted at birth, and increases risk of adult T cell leukaemia lymphoma
Which type of cells are infected by EBV?
How are EBV-expressing B cells usually eliminated?
Cytotoxic T cell function
What type of lymphoma does h pylori infection predispose to?
Burkitt lymphoma expresses high level of c-myc oncoprotein, why?
Recombination error: on chromosome 14
IgH promotor usually promotes Ig heavy chain production
Mutation in IgH promoter --> c-myc promotion
Mutation is t(8;14)
What are the 2 broad subtypes of Non-Hodgkins lymphoma?
B and T cell type
What are the subtypes of B cell NHL?
Low grade: follicular, small lymphocytic, marginal zone
High grade: diffuse large cell, Burkitt's
Aggressive: mantle cell
What test can prove germinal centre origin of a lymphoma?
Positive staining for CD10 and bcl6
What is the classification of Burkitt's lymphoma
High grade peripheral B cell lymphoma
What gene mutation is associated with follicular lymphoma?
t(14;18) - it causes overexpression of the bcl-2 gene
Which lymphoma typically has a 'starry sky appearance' on histology?
Where does TCR gene recombination occur?
What are the key enzymes involved in VDJ (TCR gene) recombination?
RAG1 and RAG2
What are the 2 methods of gene recombination in B cells?
What is the key enzyme involved in B cell class switching?
Which lymphoma are coeliac's predisposed to?
EATL (enteropathy-associated t cell lymphoma)
What can PCR be used for in lymphoma diagnosis?
2. TCR rearrangement
3. IG gene rearrangement
What is the translocation t(11;14) diagnostic of?
Mantle cell lymphoma
What is the translocation of t(2;5) associated with?
A better prognosis for aplastic large cell lymphoma
Which lymphoma shows aberrant CD5 and cyclin D1 expression?
Mantle cell lymphoma
Which type of lymphoma can cause either a jaw or abdominal mass?
Recall one good and one bad prognostic indicator in Burkitt's lymphoma?
Good: germinal centre phenotype
Bad: p53 mutation
What is the grade of peripheral T cell lymphomas?
Which lymphoma is particularly common in Japan and the Caribbean?
Adult T cell leukaemia lymphoma