Haematology 10 - Lymphoma 1: multidisciplinary Flashcards Preview

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Flashcards in Haematology 10 - Lymphoma 1: multidisciplinary Deck (44)
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1

What is multiple myeloma a malignancy of?

Plasma cells

2

Why do bacterial infections and autoimmune disorders increase lymphoma risk?

Constant antigenic stimulation

3

Why do viral infections increase lymphoma risk?

Direct viral integration of lymphocytes

4

Which lymphoma does Sjorgen's syndrome increase risk of?

Marginal zone lymphoma of the parotid

5

Which lymphoma does Hashimoto's syndrome increase risk of?

Marginal zone lymphoma of the thyroid

6

How is HTLV1 transmitted, and which cancer does it increase risk of?

A retrovirus that is transmitted at birth, and increases risk of adult T cell leukaemia lymphoma

7

Which type of cells are infected by EBV?

B cells

8

How are EBV-expressing B cells usually eliminated?

Cytotoxic T cell function

9

What type of lymphoma does h pylori infection predispose to?

Gastric MALT

10

Burkitt lymphoma expresses high level of c-myc oncoprotein, why?

Recombination error: on chromosome 14
IgH promotor usually promotes Ig heavy chain production
Mutation in IgH promoter --> c-myc promotion
Mutation is t(8;14)

11

What are the 2 broad subtypes of Non-Hodgkins lymphoma?

B and T cell type

12

What are the subtypes of B cell NHL?

Low grade: follicular, small lymphocytic, marginal zone
High grade: diffuse large cell, Burkitt's
Aggressive: mantle cell

13

What test can prove germinal centre origin of a lymphoma?

Positive staining for CD10 and bcl6

14

What is the classification of Burkitt's lymphoma

High grade peripheral B cell lymphoma

15

What gene mutation is associated with follicular lymphoma?

t(14;18) - it causes overexpression of the bcl-2 gene

16

Which lymphoma typically has a 'starry sky appearance' on histology?

Burkitt's lymohoma

17

Where does TCR gene recombination occur?

Bone marrow

18

What are the key enzymes involved in VDJ (TCR gene) recombination?

RAG1 and RAG2

19

What are the 2 methods of gene recombination in B cells?

Class switching
Somatic hypermutation

20

What is the key enzyme involved in B cell class switching?

Adenosine-induced deaminase

21

Which lymphoma are coeliac's predisposed to?

EATL (enteropathy-associated t cell lymphoma)

22

What can PCR be used for in lymphoma diagnosis?

Identifying:
1. Translocations
2. TCR rearrangement
3. IG gene rearrangement

23

What is the translocation t(11;14) diagnostic of?

Mantle cell lymphoma

24

What is the translocation of t(2;5) associated with?

A better prognosis for aplastic large cell lymphoma

25

Which lymphoma shows aberrant CD5 and cyclin D1 expression?

Mantle cell lymphoma

26

Which type of lymphoma can cause either a jaw or abdominal mass?

Burkitt's lymphoma

27

Recall one good and one bad prognostic indicator in Burkitt's lymphoma?

Good: germinal centre phenotype
Bad: p53 mutation

28

What is the grade of peripheral T cell lymphomas?

V aggressive

29

Which lymphoma is particularly common in Japan and the Caribbean?

Adult T cell leukaemia lymphoma

30

What is cutaneous T cell lymphoma known as?

Mycosis fungoides

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