Histopathology 2 - Bone tumours Flashcards Preview

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Flashcards in Histopathology 2 - Bone tumours Deck (19)
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1

What is the preferred investigation for diagnosing bone tumours?

Core biopsy under radiological guidance

2

What is "shepherd's crook deformity" a reference to?

Fibrous dysplasia involving the femoral head

3

Recall 4 tumour-like conditions of the bone that are not actually malignant

1. Fibrous dysplasia
2. Fibroma (can be ossifying/ non-ossifying)
3. Reparative giant cell granuloma
4. Simple bone cyst

4

How does osteochondroma mimic bone in appearance?

They have a cartilaginous surface overlying normal cortical + trabecular bone

5

In which bones is osteochondroma most likely to present?

Long bones

6

How will osteochondroma appear on XR?

"popcorn" pattern

7

Is a giant cell tumour of bone benign or malignant?

Borderline malignant

8

What is the typical age of presentation of osteochondroma?

20-40 years

9

What is the typical age of presentation of giant cell tumour of bone?

20-40 years

10

How do giant cell bone tumours appear under the microscope?

Osteoclasts on a background of ovoid cells

11

What are the 3 types of malignant bone tumour?

Osteosarcoma (bone-forming)
Chondrosarcoma (cartilage-forming)
Ewing's sarcoma (undifferentiated mesenchymal)

12

Recall the typical age of presentation for each of the 3 types of malignant bone tumour

Osteosarcoma: <30 years
Chondrosarcoma: >40 years
Ewing's sarcoma: <20 years

13

Recall the typical site affected for each of the 3 types of malignant bone tumour

Osteosarcoma: knee
Chondrosarcoma: pelvis/ proximal skeleton
Ewing's sarcoma: long bones + pelvis

14

Recall the typical X ray appearance of each of the 3 types of malignant bone tumour

Osteosarcoma: Codman's triangle
Chondrosarcoma: fluffy calcification
Ewing's sarcoma: Onion-skinning of periosteum

15

What is a "Codman's triangle"?

The triangular area of new subperiosteal bone that is created when a lesion, often a tumour, raises the periosteum away from the bone.

16

Which of the 3 types of malignant bone tumour has the best prognosis?

Chondrosarcoma

17

What gene mutation is associated with Ewing's sarcoma?

11:22 translocation

18

Which type of malignant bone tumour will stain for CD99 and MICC2?

Ewing's sarcoma

19

Which patients are most at risk of developing Ewing's tumour in soft tissue?

Immunocompromised patients

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