Flashcards in Histopathology 2 - Bone tumours Deck (19)
What is the preferred investigation for diagnosing bone tumours?
Core biopsy under radiological guidance
What is "shepherd's crook deformity" a reference to?
Fibrous dysplasia involving the femoral head
Recall 4 tumour-like conditions of the bone that are not actually malignant
1. Fibrous dysplasia
2. Fibroma (can be ossifying/ non-ossifying)
3. Reparative giant cell granuloma
4. Simple bone cyst
How does osteochondroma mimic bone in appearance?
They have a cartilaginous surface overlying normal cortical + trabecular bone
In which bones is osteochondroma most likely to present?
How will osteochondroma appear on XR?
Is a giant cell tumour of bone benign or malignant?
What is the typical age of presentation of osteochondroma?
What is the typical age of presentation of giant cell tumour of bone?
How do giant cell bone tumours appear under the microscope?
Osteoclasts on a background of ovoid cells
What are the 3 types of malignant bone tumour?
Ewing's sarcoma (undifferentiated mesenchymal)
Recall the typical age of presentation for each of the 3 types of malignant bone tumour
Osteosarcoma: <30 years
Chondrosarcoma: >40 years
Ewing's sarcoma: <20 years
Recall the typical site affected for each of the 3 types of malignant bone tumour
Chondrosarcoma: pelvis/ proximal skeleton
Ewing's sarcoma: long bones + pelvis
Recall the typical X ray appearance of each of the 3 types of malignant bone tumour
Osteosarcoma: Codman's triangle
Chondrosarcoma: fluffy calcification
Ewing's sarcoma: Onion-skinning of periosteum
What is a "Codman's triangle"?
The triangular area of new subperiosteal bone that is created when a lesion, often a tumour, raises the periosteum away from the bone.
Which of the 3 types of malignant bone tumour has the best prognosis?
What gene mutation is associated with Ewing's sarcoma?
Which type of malignant bone tumour will stain for CD99 and MICC2?