Histopathology 1 - Fundamentals of histology Flashcards Preview

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Flashcards in Histopathology 1 - Fundamentals of histology Deck (18)
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1

What type of cell is predominant in the inflammatory process in acute appendicitis/gastritis/mastitis?

Neutrophilic inflammation

2

What are the 4 main causes of eosinophilia?

1. Allergic reactions

2. Parasitic reactions

3. Tumous eg Hodgkin's disease (not a neoplasm of eosinophils but a reaction to the neoplastic process)

4. Eosinophilic granulomatosis

3

If 'feline contractions' are observed in the oesophagus, what is the pathology?

Eosinophilic oesophagitis - probably due to a food allergen ("asthma of the oesophagus")

4

Which cells are most associated with LATE acute inflammation and granulomas

Macrophages

5

What is a granuloma?

Organised collection of activated macrophages

6

What are the 2 most likely causes of granulomas?

Sarcoid
TB

7

What is a carcinoma?

Malignant tumour of epithlial cells

8

What are the 2 key histological features of a squamous cell carcinoma?

Keratin production
Intercellular bridges

9

What are the 2 key histological features of an adenocarcinoma?

Mucin production
Glands

10

What is the basic principle of how immuno-histochemistry works?

Use an antibody to a particular antigen in a tumour and then use stains that detect those antibodies

11

How do histochemical stains work?

Chemical reaction between chemicals added in the stain and the tissue that causes a change in colour

12

What is used to stain amyloid?

Congo red stain

13

How does amyloid appear under polarised light?

Apple green birefringeance

14

Which polymorphs have a bilobed nucleus?

Eosinophils

15

What is cytokeratin a marker of?

Epithelial cells - so can identify carcinomas

16

What is CD45 a marker of?

Lymphoid cells - so can identify lymphomas

17

What stain can be used to detect melanin?

Fontana

18

What stain can be used to detect iron (eg in haemachromatosis)?

Prussian Blue (think Prussia hated on both sides of IRON curtain)

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