Test 33

Question 1

Tx for LOC brought about by severe hypoglycemia

Answer 1

Glucagon

Increases hepatic glycogenolysis and gluconeogenesis stopping hypoglycemia

Question 2

SCD pt
fever
exquisite thigh pain
bacteriemia

Answer 2

Salmonella osteomyelitis

Question 3

nonlactose fermenting
oxidase negative
motile grame negative with special Vi capsule
Endotoxin

Answer 3

Salmonella

Vi capsule protects it from opsonization and phagocytosis

Question 4

toxins that inactivate the 60S ribosome by remvooing adenine from rRNA

Answer 4

shigella (shiga toxin)

EHEC- SLT

Question 5

inactivate EF2

Answer 5

C. diptheriae

p. areguinosa

Question 6

empiric treatment of coagulase negative Stpah

Answer 6

Vancomycin

Question 7

methicillin susceptibile isolate of caog negative stpah infeciton

Answer 7

swith to nafciliin

oxacillin

Question 8

class of antiarrhythmics that demonstrate the most use dependence and class that has the least

Answer 8

1C> 1A>1B

channels spend less time in resting state

Question 9

use dependence

Answer 9

higher rates of depolarization lead to incrased Na channel blockade d/t channels spending LESS time in the resting state

Question 10

1A

Answer 10

Disopyramide
Procainamide
Quinidine

Question 11

1B

Answer 11

Lidocaine

Mexiletine

Question 12

1C

Answer 12

Flecainide
Propafenone

slowly dissociate so blocking effect accumulates over multiple cardiac cycles

Question 13

drugs taht bind and block activated and inactivated VG Na channels in cardiac pacemaker cells and mycocytes

Answer 13

class 1 antiarrhythmics

Question 14

First line therapy for chronic asthma

has the strongest and most predicatable effect on inflammatory component of asthma

Answer 14

corticosteroid

Fluticasone
budesonide

inhibit synthesis of all cytokines

Question 15

how to inactivate HAV

Answer 15

water chlorination
bleach
formalin
UV
boiling for 1 minute

Question 16

pure opoid receptor antagonist used for treating opoid intoxication/overdose

has greatest affinity for mu receptors

Answer 16

Naloxone

Question 17

reverses both CNS and periopheral sxs of SEVERE ATROPINE toxicity

Answer 17

physostigmine (phyxes atropine OD)

Question 18

atropine

Answer 18

BLOCKS Ach receptors (antimuscarinic)

Question 19

physostimine

Answer 19

inhibits AChesterase to increase Ach availabiilty and counteract atropin blockade

Question 20

rapid plasma decay of thiopental

Answer 20

redistribution of drug to other tissues in the body

Question 21

what type of monitoring needs to be done w/ cloazpine

Answer 21

WBC monitoring

Question 22

acute management of venous thrombosis or thromboembolism

Answer 22

heparin

activates antithrombin III

Question 23

contains transmembrane domains composed of alpha helices w/ hydrophobic AA residues like Valine, Alanine
isoleucine, methionine
phenylalanicne

Answer 23

integral membrane proteins that span the cellular membrane

Question 24

binds and inhibits viral DNA/RNA pol and HIV RT inhibitor that DOES NOT requie activation by viral kinase

Answer 24

Foscarnet

Question 25

sialic acid analogue inhibitor of influenza A and B virus neuraminadase

Answer 25

oseltamivir

Question 26

saquinavir

Answer 26

protease inhibitor that binds to catalytic site of HIV aspartic protease and prevents cleave of polyprotein precursors

Question 27

cytosine anallog that is a NRTI that must be phosphorylated to its active form

Answer 27

lamivudine

Question 28

polymorphic QRS complex that chagnes in amp and legnth

Answer 28

ECG

Question 29

Antiarrhythmic agents that cuase torsades

Answer 29

kPDQ aIDS

Question 30

protease inhibitor that causes hyperglycemia, lipodystrophy, inhibits p450

Answer 30

indinavir