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Flashcards in Test 93 Deck (44):
1

Trousseau's syndrome

migratory superficial thrombophlebitis--indication of a visceral cancer!!

2

several episodes of thrombophlebitis in various sites in both arms and legds

visceral cancer!!


hypercoagulatbility is a common paraneoplastic sydnrome commonly seen with adenocarcinomas of hte pancreas, colon and lung

3

survives inside MPHAGES
dauses a disseminated mycosis in IMmunoCOMP pts

SYSTEMIC sxs
painful oral ulcers
lymphadenopathy
hepatosplenogmegaly

Histoplasma capsulatum

**may also see hilar adenopathy

4

Aspergillus fumigatus

MONOmorphic fungi w/ ONLY a mold form

seen in tissue w/ ACUTE ANGLE V shaped branidng

5

Most frequent opportunistic pathogen

extracellular

forms ovoid yeast cells w/ pseudohyphae

CAndida

6

causes meningoencephalitis, pulmonary crtptoccocis in those w/ HIV

has a LARGE polysaccharide capsule (INDIA INK YO)

Cryptococus neoformas

7

can cause a disseminiated mycosis in immunocomp pts

large thicked walled spherules w/ endosspores

coccioides immits

8

counteract PNS stimulation of vagus causing bronchoconstriction in lungs

tiotroprium
ipratropium

9

ABrupt onset of gross hematuria in a pt w/ sickle cell disease


dark rust colored or bloody urine and acute coliky flank pain d/t acute utreteral obstruction from sloughed paipillae


COMMON SXS!!

Papillary necrosis!

(anything that decreases renal blood flow)

seen w/ sickle cell
DM
analgesic nephroapthy

severe obstrucive pyelonephritis

10

Muddy brown granular casts in hospitalized pt w/ oliguira

ischemic tubular necrosis

11

microangiopathic hemolytic anemia
thrombocytopenia
ARF

HUS

12

IL-1
IL-6
TNFa

mediate SYSTEMIC inflammatory response
stimulate hepatic secretion of acute phase proteins (fibrinogen)

High levels of circulating fibringoen increased ESR

13

heavy, red, boggy lobe

congestion

alveolar exudate contains mostly bacteria

14

red firm lobe liver like consistancey

red hepaization

alveolar exudate w/ RBC, neutrophils, fibirin

15

gray brown firm lobe

gray hepatatization

RBC disintegrate

alveolar exudste contains neutrophils and fibrin

16

most likely cause of fatigue and new onset cardiac murmur in young adult

bacterial endocarditis

17

complication of bacteria lendocarditis

acute diffuse proliferative glomerulonephritis secondary to circulating immune complexes

18

children

intussusception

19

hypersecretion of gastrin by a pancreatic tumor

ZE syndrome

increases gastric acid secretion> peptic ulcers

diarrhea is another common sx

20

chronic antral predominant gastritis

h. pylori infection

21

biphasic pattern of cellularity (highly cellular areas intermixed w/ myxoid regions of LOW cellularity)

Verocay bodies

S100 positivity
arise from peripheral nerves, nerve roots and cranial nerves

Schwannomas!!


often at cerebellopontine angle at CNVIII

22

anotehr important S100 + tumor

melanoma (schwannoma)

23

bizarre loking glial cells w/ mitotic figures
PSEUDOPALISADING necrosis
often in WHITE MATTER

crosses corpus collosum

glioblastoma

24

arise from cells of arachnoid

cells in whorls with psammoma bodies

meningiomas

25

optic glioma

commonly seen w/ NF1 (rosenthal fibers)

26

demyelinated plaques

MS

27

large intracytoplasmic vacuoles (spongiform)

CFJ D

28

HTN
basal ganglia
cerebellum
thalamus
pons
intracerebral hemorrhage
progressive neuro deficits

charcot bouchard

29

APKD, ED
circle of willis
2025 mm
SUB arachonoid hemorrhage

SUDDEN severe HA

no FOCAL neuro deficitis

sacccular (berry) anneurysms

30

deep intraparenchymal hemorrhage caused by hypertensive vasculopathy of small penetrating branches of cerebral arteries

charcot bouchard

31

ATN

can be assocaited w/ multiorgan FAILURE> most pts experience tubular re-epitheliazation adn REG'AIN normal renal fucntion

32

ortner syndrome

mitral stenosis > left atrial dilation sufficient to impinge on recurrent largyngeal nerve (HOARSENESS)

33

rising fever, bacteremia, brdaycardia>

abdominal pain rose spots>

hepatosplenomegaly, intestinal bleeding

typhoid fever

penetrates gut via phagocytosis by M cells

34

involuntary, rapid, irregular jerking movements involiving face arms and legs

syndham chorea

can occur MONTHS after GAS infection and is one of hte MAJOR clinical manifestations of ACute RF

**these pts have a high risk of valve disease

35

transmural inflammation w/ fibrinoid necrosis

PAN

associated w/ HBV!!!! in 10-30% of cases

36

granulomas w/ eosinophilic necrosis

churg strauss

37

impaired bone matrix formation

OI

bone matrix = hydroxy apatite crystals and type I colagen components

38

defect in mineralization of bone matrix

vit D def

39

endochondral ossification

long bones

40

intramembranous ossification

flat bones

41

rare but SEVERE complication of halothane exposure

massive HEPATIC NECROSIS

occurs d/t direct liver injury by halothane metabolites and formation of autoAbs against liver progetins

CENTRILOBULAR hepatic necrosis

42

microvesicular fatty chagne

REyes syndrome (kids 5-10 tx w/ salicylates)

43

macrovesicular fatty chagne

ETOH chronic

44

hepatic grannulomatosis

methyldopa
hydralazine
quinidine