Cancer Genetics Flashcards Preview

Fundamentals of Molecular Medicine > Cancer Genetics > Flashcards

Flashcards in Cancer Genetics Deck (44):
1

 

 

 

Topics 

2

 

 

 

What is Cancer?

3

 

 

 

Cancer Treatment Types

4

 

 

 

Cancer Screening 

5

 

 

 

Constitutional Cancer Symptoms

6

 

 

 

Other Symptoms

7

 

 

 

Complex Traits

8

 

 

 

Sporadic Mutations

9

 

 

 

Familial Mutations

10

 

 

 

Hereditary 

11

 

 

 

Frequency of Sporadic vs. Familial vs. Hereditary

12

 

 

 

Indications of Family Cancer Syndromes

13

 

 

 

Tumor Supressor Genes and Loss of Heterozygosity 

14

 

 

 

James Bond Model for Cancer

15

 

 

 

Knudson Hypothesis 

16

17

18

19

20

 

 

 

LiFraumani Syndrome and the Function of P53

21

22

 

 

 

Cause of Retinoblastoma and function of RB1

23

 

 

 

CDK, RB, and E2F Interplay 

24

 

 

 

Cause of Hereditary Breast Cancer

25

 

 

 

Function of BRCA1 and 2

26

 

 

 

PARP-1 Inhibitors

27

 

 

 

Cause of Familial Adenomatous Polyposis

28

 

 

 

Interplay of Beta Catenin and APC

29

 

 

 

Mutations Downstream from APC

30

 

 

 

Cause of Wilms Tumor and WT1

31

32

 

 

 

Cause of Neurofibromatosis Type 1 and role of underlying gene

33

 

 

 

What is the most Common Form of Skin Cancer in the US

34

 

 

 

Most Common Form of Skin Cancer

35

 

 

 

Role of Patched

36

 

 

 

Role of SMO

37

 

 

 

Interplay of PTCH and SMO in Normal Cells

38

 

 

 

Stimilation of Proliferation in Normal Cells

39

 

 

 

What happens when PTCH Mutates?

40

 

 

 

Familial Mutation of PTCH

41

 

 

 

Targeted Therapy

42

 

 

 

Cause of Familial Melanoma and it's underlying Gene

43

 

 

 

Role of P14

44

 

 

 

Malignant Melanoma and Squamous Cell Carcinoma

Decks in Fundamentals of Molecular Medicine Class (77):