Cancer Genetics Flashcards Preview

Fundamentals of Molecular Medicine > Cancer Genetics > Flashcards

Flashcards in Cancer Genetics Deck (44)
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1
Q

Topics

A
2
Q

What is Cancer?

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3
Q

Cancer Treatment Types

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4
Q

Cancer Screening

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5
Q

Constitutional Cancer Symptoms

A
6
Q

Other Symptoms

A
7
Q

Complex Traits

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8
Q

Sporadic Mutations

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9
Q

Familial Mutations

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10
Q

Hereditary

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11
Q

Frequency of Sporadic vs. Familial vs. Hereditary

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12
Q

Indications of Family Cancer Syndromes

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13
Q

Tumor Supressor Genes and Loss of Heterozygosity

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14
Q

James Bond Model for Cancer

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15
Q

Knudson Hypothesis

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16
Q
A
17
Q
A
18
Q
A
19
Q
A
20
Q

LiFraumani Syndrome and the Function of P53

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21
Q
A
22
Q

Cause of Retinoblastoma and function of RB1

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23
Q

CDK, RB, and E2F Interplay

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24
Q

Cause of Hereditary Breast Cancer

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25
Q

Function of BRCA1 and 2

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26
Q

PARP-1 Inhibitors

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27
Q

Cause of Familial Adenomatous Polyposis

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28
Q

Interplay of Beta Catenin and APC

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29
Q

Mutations Downstream from APC

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30
Q

Cause of Wilms Tumor and WT1

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31
Q
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32
Q

Cause of Neurofibromatosis Type 1 and role of underlying gene

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33
Q

What is the most Common Form of Skin Cancer in the US

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34
Q

Most Common Form of Skin Cancer

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35
Q

Role of Patched

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36
Q

Role of SMO

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37
Q

Interplay of PTCH and SMO in Normal Cells

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38
Q

Stimilation of Proliferation in Normal Cells

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39
Q

What happens when PTCH Mutates?

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40
Q

Familial Mutation of PTCH

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41
Q

Targeted Therapy

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42
Q

Cause of Familial Melanoma and it’s underlying Gene

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43
Q

Role of P14

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44
Q

Malignant Melanoma and Squamous Cell Carcinoma

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Decks in Fundamentals of Molecular Medicine Class (77):