Cancer Genetics Flashcards
(44 cards)
1
Q
Topics
A
2
Q
What is Cancer?
A
3
Q
Cancer Treatment Types
A
4
Q
Cancer Screening
A
5
Q
Constitutional Cancer Symptoms
A
6
Q
Other Symptoms
A
7
Q
Complex Traits
A
8
Q
Sporadic Mutations
A
9
Q
Familial Mutations
A
10
Q
Hereditary
A
11
Q
Frequency of Sporadic vs. Familial vs. Hereditary
A
12
Q
Indications of Family Cancer Syndromes
A
13
Q
Tumor Supressor Genes and Loss of Heterozygosity
A
14
Q
James Bond Model for Cancer
A
15
Q
Knudson Hypothesis
A
16
Q
A
17
Q
A
18
Q
A
19
Q
A
20
Q
LiFraumani Syndrome and the Function of P53
A
21
Q
A
22
Q
Cause of Retinoblastoma and function of RB1
A
23
Q
CDK, RB, and E2F Interplay
A
24
Q
Cause of Hereditary Breast Cancer
A
25
Function of BRCA1 and 2
26
PARP-1 Inhibitors
27
Cause of Familial Adenomatous Polyposis
28
Interplay of Beta Catenin and APC
29
Mutations Downstream from APC
30
Cause of Wilms Tumor and WT1
31
32
Cause of Neurofibromatosis Type 1 and role of underlying gene
33
What is the most Common Form of Skin Cancer in the US
34
Most Common Form of Skin Cancer
35
Role of Patched
36
Role of SMO
37
Interplay of PTCH and SMO in Normal Cells
38
Stimilation of Proliferation in Normal Cells
39
What happens when PTCH Mutates?
40
Familial Mutation of PTCH
41
Targeted Therapy
42
Cause of Familial Melanoma and it's underlying Gene
43
Role of P14
44
Malignant Melanoma and Squamous Cell Carcinoma
