Topics
What is Cancer?
Cancer Treatment Types
Cancer Screening
Constitutional Cancer Symptoms
Other Symptoms
Complex Traits
Sporadic Mutations
Familial Mutations
Hereditary
Frequency of Sporadic vs. Familial vs. Hereditary
Indications of Family Cancer Syndromes
Tumor Supressor Genes and Loss of Heterozygosity
James Bond Model for Cancer
Knudson Hypothesis
LiFraumani Syndrome and the Function of P53
Cause of Retinoblastoma and function of RB1
CDK, RB, and E2F Interplay
Cause of Hereditary Breast Cancer
Function of BRCA1 and 2
PARP-1 Inhibitors
Cause of Familial Adenomatous Polyposis
Interplay of Beta Catenin and APC
Mutations Downstream from APC
Cause of Wilms Tumor and WT1
Cause of Neurofibromatosis Type 1 and role of underlying gene
What is the most Common Form of Skin Cancer in the US
Most Common Form of Skin Cancer
Role of Patched
Role of SMO
Interplay of PTCH and SMO in Normal Cells
Stimilation of Proliferation in Normal Cells
What happens when PTCH Mutates?
Familial Mutation of PTCH
Targeted Therapy
Cause of Familial Melanoma and it’s underlying Gene
Role of P14
Malignant Melanoma and Squamous Cell Carcinoma