Protein Folding, Structure, and Function Flashcards Preview

Fundamentals of Molecular Medicine > Protein Folding, Structure, and Function > Flashcards

Flashcards in Protein Folding, Structure, and Function Deck (62):
1

 

 

 

Function and Roles of Proteins

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Proteins fail to fold Correctly

3

 

 

 

Protein is not stable enough to preform its normal function

4

 

 

 

Fails to be correctly trafficked

5

 

 

 

Diseases of insolube aggregates

6

 

 

 

Cellular Consequences of Protein Aggregation

7

 

 

 

Relevant Protein Folding Diseases

8

 

 

 

Protein Structure and Folding

9

 

 

 

Monomeric Protein Subunits:

Variety

Diversity

10

 

 

 

Calculating # of possible sequences in proteins

11

 

 

 

Generalized Amino Acids

12

 

 

 

Amino Acids basic structure and L vs. D distinction

13

 

 

 

Non-Polar Aliphatic AA's

 

14

 

 

 

Aromatic Amino Acids

15

 

 

 

Polar Uncharged AA's

16

 

 

 

Sulfur Containing 

17

 

 

 

Charged AA's

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Short Names of AA's

19

 

 

 

Sulfur Containing Amino Acid Interactions

20

 

 

 

Amino Acid Side Chain Ionizations

21

 

 

 

Globular Proteins

22

 

 

 

Fibrous Proteins 

23

 

 

 

Transmembrane Proteins

24

 

 

 

Primary Level of Globular Protein Structure

25

 

 

 

Secondary Level of Globular Protein Structure

26

 

 

 

Tertiary Level of Globular Protein Structure

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Quaternary Level of Globular Protein Structure

 

 

Not all proteins have Quaternary Structures. 

Hemoglobin is a tetramer

Myoglobin is a monomer

28

 

 

 

Peptide Bond Formation 

29

 

 

 

Amino Acids are linked by?

30

 

 

 

Geometry of Peptide Bonds

31

 

 

 

Primary sequence determines?

32

 

 

 

Components of Secondary Structure

33

 

 

 

The Alpha Helix

34

 

 

 

Identifying the Helix Type

35

 

 

 

Beta Sheets

36

 

 

 

The Beta Sheet 

37

 

 

 

The Reverse Turn 

38

 

 

 

Tertiaruy Structure includes all...

39

 

 

 

Protein Diversity 

40

 

 

 

Solubility of Globular Proteins

41

 

 

 

Quaternary Structure

42

 

 

 

2 Examples of Proteins with Quaternary Structure

43

 

 

 

Protein Protein Interactions

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45

 

 

 

Entropy of Polypeptide chain favors...

46

 

 

 

Major Force Resonsible for Folding

47

 

 

 

As Protein Increases Size...

48

 

 

 

Native State Stabilization 

49

 

 

 

Molecular Chaperones

50

 

 

 

Protein Misfolding Diseases

51

 

 

 

Prion Diseases

52

 

 

 

Difference between PrPc and PrPsc

53

 

 

 

Prion Conformational Change

54

 

 

 

Conformational Differences 

55

 

 

 

Model of Protein Misfolding and Propagation 

56

 

 

 

Protein Misfolding Diseases

57

 

 

 

A closer look at Amyloidoses

58

 

 

 

Causes of formation of Amyloid Fibrils

59

 

 

 

Mechanism of Amyloid Fibril Formation 

60

 

 

 

Amyloid Fibril Fomration Cont.

61

 

 

 

Consequences of Amyloid Fibril Formation 

62

 

 

 

Therapeutic Approaches to Amyloid Fibril Formation 

Decks in Fundamentals of Molecular Medicine Class (77):