Protein Folding, Structure, and Function Flashcards
1
Q
Function and Roles of Proteins
A
2
Q
Proteins fail to fold Correctly
A
3
Q
Protein is not stable enough to preform its normal function
A
4
Q
Fails to be correctly trafficked
A
5
Q
Diseases of insolube aggregates
A
6
Q
Cellular Consequences of Protein Aggregation
A
7
Q
Relevant Protein Folding Diseases
A
8
Q
Protein Structure and Folding
A
9
Q
Monomeric Protein Subunits:
Variety
Diversity
A
10
Q
Calculating # of possible sequences in proteins
A
11
Q
Generalized Amino Acids
A
12
Q
Amino Acids basic structure and L vs. D distinction
A
13
Q
Non-Polar Aliphatic AA’s
A
14
Q
Aromatic Amino Acids
A
15
Q
Polar Uncharged AA’s
A
16
Q
Sulfur Containing
A
17
Q
Charged AA’s
A
18
Q
Short Names of AA’s
A
19
Q
Sulfur Containing Amino Acid Interactions
A
20
Q
Amino Acid Side Chain Ionizations
A
21
Q
Globular Proteins
A
22
Q
Fibrous Proteins
A
23
Q
Transmembrane Proteins
A
24
Q
Primary Level of Globular Protein Structure
A
25
Secondary Level of Globular Protein Structure
26
Tertiary Level of Globular Protein Structure
27
Quaternary Level of Globular Protein Structure
Not all proteins have Quaternary Structures.
Hemoglobin is a tetramer
Myoglobin is a monomer
28
Peptide Bond Formation
29
Amino Acids are linked by?
30
Geometry of Peptide Bonds
31
Primary sequence determines?
32
Components of Secondary Structure
33
The Alpha Helix
34
Identifying the Helix Type
35
Beta Sheets
36
The Beta Sheet
37
The Reverse Turn
38
Tertiaruy Structure includes all...
39
Protein Diversity
40
Solubility of Globular Proteins
41
Quaternary Structure
42
2 Examples of Proteins with Quaternary Structure
43
Protein Protein Interactions
44
45
Entropy of Polypeptide chain favors...
46
Major Force Resonsible for Folding
47
As Protein Increases Size...
48
Native State Stabilization
49
Molecular Chaperones
50
Protein Misfolding Diseases
51
Prion Diseases
52
Difference between PrPc and PrPsc
53
Prion Conformational Change
54
Conformational Differences
55
Model of Protein Misfolding and Propagation
56
Protein Misfolding Diseases
57
A closer look at Amyloidoses
58
Causes of formation of Amyloid Fibrils
59
Mechanism of Amyloid Fibril Formation
60
Amyloid Fibril Fomration Cont.
61
Consequences of Amyloid Fibril Formation
62
Therapeutic Approaches to Amyloid Fibril Formation
