Protein Folding, Structure, and Function Flashcards Preview

Fundamentals of Molecular Medicine > Protein Folding, Structure, and Function > Flashcards

Flashcards in Protein Folding, Structure, and Function Deck (62):
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Function and Roles of Proteins

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Proteins fail to fold Correctly

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Protein is not stable enough to preform its normal function

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Fails to be correctly trafficked

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5

 

 

 

Diseases of insolube aggregates

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Cellular Consequences of Protein Aggregation

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Relevant Protein Folding Diseases

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8

 

 

 

Protein Structure and Folding

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9

 

 

 

Monomeric Protein Subunits:

Variety

Diversity

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10

 

 

 

Calculating # of possible sequences in proteins

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11

 

 

 

Generalized Amino Acids

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Amino Acids basic structure and L vs. D distinction

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13

 

 

 

Non-Polar Aliphatic AA's

 

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14

 

 

 

Aromatic Amino Acids

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Polar Uncharged AA's

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Sulfur Containing 

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Charged AA's

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18

 

 

 

Short Names of AA's

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19

 

 

 

Sulfur Containing Amino Acid Interactions

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20

 

 

 

Amino Acid Side Chain Ionizations

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21

 

 

 

Globular Proteins

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22

 

 

 

Fibrous Proteins 

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Transmembrane Proteins

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24

 

 

 

Primary Level of Globular Protein Structure

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25

 

 

 

Secondary Level of Globular Protein Structure

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Tertiary Level of Globular Protein Structure

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27

 

 

 

Quaternary Level of Globular Protein Structure

 

 

Not all proteins have Quaternary Structures. 

Hemoglobin is a tetramer

Myoglobin is a monomer

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Peptide Bond Formation 

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Amino Acids are linked by?

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30

 

 

 

Geometry of Peptide Bonds

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31

 

 

 

Primary sequence determines?

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32

 

 

 

Components of Secondary Structure

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33

 

 

 

The Alpha Helix

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34

 

 

 

Identifying the Helix Type

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35

 

 

 

Beta Sheets

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36

 

 

 

The Beta Sheet 

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37

 

 

 

The Reverse Turn 

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38

 

 

 

Tertiaruy Structure includes all...

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39

 

 

 

Protein Diversity 

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40

 

 

 

Solubility of Globular Proteins

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Quaternary Structure

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42

 

 

 

2 Examples of Proteins with Quaternary Structure

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Protein Protein Interactions

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45

 

 

 

Entropy of Polypeptide chain favors...

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46

 

 

 

Major Force Resonsible for Folding

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As Protein Increases Size...

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48

 

 

 

Native State Stabilization 

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49

 

 

 

Molecular Chaperones

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50

 

 

 

Protein Misfolding Diseases

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51

 

 

 

Prion Diseases

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52

 

 

 

Difference between PrPc and PrPsc

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53

 

 

 

Prion Conformational Change

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54

 

 

 

Conformational Differences 

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55

 

 

 

Model of Protein Misfolding and Propagation 

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Protein Misfolding Diseases

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57

 

 

 

A closer look at Amyloidoses

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58

 

 

 

Causes of formation of Amyloid Fibrils

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Mechanism of Amyloid Fibril Formation 

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60

 

 

 

Amyloid Fibril Fomration Cont.

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61

 

 

 

Consequences of Amyloid Fibril Formation 

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Therapeutic Approaches to Amyloid Fibril Formation 

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Decks in Fundamentals of Molecular Medicine Class (77):