Function and Roles of Proteins
Proteins fail to fold Correctly
Protein is not stable enough to preform its normal function
Fails to be correctly trafficked
Diseases of insolube aggregates
Cellular Consequences of Protein Aggregation
Relevant Protein Folding Diseases
Protein Structure and Folding
Monomeric Protein Subunits:
Variety
Diversity
Calculating # of possible sequences in proteins
Generalized Amino Acids
Amino Acids basic structure and L vs. D distinction
Non-Polar Aliphatic AA’s
Aromatic Amino Acids
Polar Uncharged AA’s
Sulfur Containing
Charged AA’s
Short Names of AA’s
Sulfur Containing Amino Acid Interactions
Amino Acid Side Chain Ionizations
Globular Proteins
Fibrous Proteins
Transmembrane Proteins
Primary Level of Globular Protein Structure
Secondary Level of Globular Protein Structure
Tertiary Level of Globular Protein Structure
Quaternary Level of Globular Protein Structure
Not all proteins have Quaternary Structures.
Hemoglobin is a tetramer
Myoglobin is a monomer
Peptide Bond Formation
Amino Acids are linked by?
Geometry of Peptide Bonds
Primary sequence determines?
Components of Secondary Structure
The Alpha Helix
Identifying the Helix Type
Beta Sheets
The Beta Sheet
The Reverse Turn
Tertiaruy Structure includes all…
Protein Diversity
Solubility of Globular Proteins
Quaternary Structure
2 Examples of Proteins with Quaternary Structure
Protein Protein Interactions
Entropy of Polypeptide chain favors…
Major Force Resonsible for Folding
As Protein Increases Size…
Native State Stabilization
Molecular Chaperones
Protein Misfolding Diseases
Prion Diseases
Difference between PrPc and PrPsc
Prion Conformational Change
Conformational Differences
Model of Protein Misfolding and Propagation
Protein Misfolding Diseases
A closer look at Amyloidoses
Causes of formation of Amyloid Fibrils
Mechanism of Amyloid Fibril Formation
Amyloid Fibril Fomration Cont.
Consequences of Amyloid Fibril Formation
Therapeutic Approaches to Amyloid Fibril Formation