Protein Folding, Structure, and Function Flashcards Preview

Fundamentals of Molecular Medicine > Protein Folding, Structure, and Function > Flashcards

Flashcards in Protein Folding, Structure, and Function Deck (62)
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1
Q

Function and Roles of Proteins

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2
Q

Proteins fail to fold Correctly

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3
Q

Protein is not stable enough to preform its normal function

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4
Q

Fails to be correctly trafficked

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5
Q

Diseases of insolube aggregates

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6
Q

Cellular Consequences of Protein Aggregation

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7
Q

Relevant Protein Folding Diseases

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8
Q

Protein Structure and Folding

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9
Q

Monomeric Protein Subunits:

Variety

Diversity

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10
Q

Calculating # of possible sequences in proteins

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11
Q

Generalized Amino Acids

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12
Q

Amino Acids basic structure and L vs. D distinction

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13
Q

Non-Polar Aliphatic AA’s

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14
Q

Aromatic Amino Acids

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15
Q

Polar Uncharged AA’s

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16
Q

Sulfur Containing

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17
Q

Charged AA’s

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18
Q

Short Names of AA’s

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19
Q

Sulfur Containing Amino Acid Interactions

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20
Q

Amino Acid Side Chain Ionizations

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21
Q

Globular Proteins

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22
Q

Fibrous Proteins

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23
Q

Transmembrane Proteins

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24
Q

Primary Level of Globular Protein Structure

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25
Q

Secondary Level of Globular Protein Structure

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26
Q

Tertiary Level of Globular Protein Structure

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27
Q

Quaternary Level of Globular Protein Structure

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Not all proteins have Quaternary Structures.

Hemoglobin is a tetramer

Myoglobin is a monomer

28
Q

Peptide Bond Formation

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29
Q

Amino Acids are linked by?

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30
Q

Geometry of Peptide Bonds

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31
Q

Primary sequence determines?

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32
Q

Components of Secondary Structure

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33
Q

The Alpha Helix

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34
Q

Identifying the Helix Type

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35
Q

Beta Sheets

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36
Q

The Beta Sheet

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37
Q

The Reverse Turn

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38
Q

Tertiaruy Structure includes all…

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39
Q

Protein Diversity

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40
Q

Solubility of Globular Proteins

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41
Q

Quaternary Structure

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42
Q

2 Examples of Proteins with Quaternary Structure

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43
Q

Protein Protein Interactions

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44
Q
A
45
Q

Entropy of Polypeptide chain favors…

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46
Q

Major Force Resonsible for Folding

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47
Q

As Protein Increases Size…

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48
Q

Native State Stabilization

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49
Q

Molecular Chaperones

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50
Q

Protein Misfolding Diseases

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51
Q

Prion Diseases

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52
Q

Difference between PrPc and PrPsc

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53
Q

Prion Conformational Change

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54
Q

Conformational Differences

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55
Q

Model of Protein Misfolding and Propagation

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56
Q

Protein Misfolding Diseases

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57
Q

A closer look at Amyloidoses

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58
Q

Causes of formation of Amyloid Fibrils

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59
Q

Mechanism of Amyloid Fibril Formation

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60
Q

Amyloid Fibril Fomration Cont.

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61
Q

Consequences of Amyloid Fibril Formation

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62
Q

Therapeutic Approaches to Amyloid Fibril Formation

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