CILS: Accumulations and Adaptations Flashcards Preview

Fundamentals of Molecular Medicine > CILS: Accumulations and Adaptations > Flashcards

Flashcards in CILS: Accumulations and Adaptations Deck (28):
1

 

 

T or F. Inclusion bodies due to viral infections can occur within the cytoplasmic space and can occur within nuclei?

 

 

 

True — Viruses need replication machinery present in the nucleus — Lead to Negri Bodies 

2

 

 

 

Herpes Virus builds up in both locations as well. 

 

 

CMV — Cytomegalovirus— “Big Cell” — Owl’s Eye — or Cowdry Type A inclusions. — nuclear inclusions and granular 

3

 

 

 

Cellular Atypia is not a histopathologic feature of Dysplasia? T or F?

 

 

 

False 

4

 

 

All accumulations are the result of either a cell’s rate of production exceeding clearance or else the failure to metabolize an endogenous substance.

 

 

 

False — Coal Dust, Pollution, Melanoma

5

 

 

 

Dysplasia is often a precursor to malignant transformation. T or F?

 

 

 

True

6

 

 

 

With amyloidosis the heart liver or kindness are not common sites.

 

 

 

False

7

 

 

A feature shared in common by both accumulations and adaptations is that both can arise from physiological and pathologic stimuli.

 

 

 

True

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9

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Both

10

 

 

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Cytomegalovirus

11

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Hypertrophy — "Box car Changes"

12

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Systolic

13

 

 

 

Features of Dystrophic Calcification

 

Atrioventricular closing shut — lub

Aortic Valve and Pulmonary Artery Close — Dub

Lub Shuh Dub — Systolic Murmur — blood is having a hard time getting out of the ventricular chamber and into the aorta. 

If you have dystrophic calcification it will have a hard time getting out of the aorta. 

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Hyperplasia. 

Lymphocyte hyperplasia which are reacting to some sort of infection. 

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Prussian blue stains — stains iron. 

Build up of iron in liver. 

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High Ferritin associated with high total body Iron levels. 

Longer Prothrombin time means blood is taking longer to clot than normal. 

Liver makes clotting Factors

17

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Primary Hemochromatosis. (Answer) Inherited form — autosomal recessive — Genetic Form

Secondary Hemochromatosis — Multiple Transfusions — Iron buildup (sometimes called Hemosiderosis)

Hemosiderosis — There’s no anemia. Sometimes only refers Iron buildup as a result of macrophage activity. 

18

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Excessive absorption of iron from the gastrointestinal tract. 

19

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Cardiac Biopsy from a middle aged man. 

Hypo-chromatic. Less organization. 

Deposits of Amyloids.

20

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21

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You need polarizing light/filter to see the congo red stain show the apple green color.

Beta pleaded structures form fibrils.  

22

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Physical Conformation — beta pleaded structure. 

Congo red stain binds to meshwork of the beta pleaded structure.

23

From among the following conditions the one responsible for the abnormalities seen in the photomicrographs seen in this conditions

Chronic Inflammation — rheumatoid arthritis

Aging

Plasma cell tumor that produces immunologlobulin light chain

A renal disease that requires chronic dialysis

Not able to be determined given the limited amount of information. 

 

 

 

Not able to be determined given the limited amount of information. — Amyloid is produced by many different causes.

24

 

 

 

They autopsy reveials calcium deposits presents in normal appearing lung and kidney tissues.

 

 

 

Parathyroid Adenoma

25

 

 

 

Increase in the number of parenchymal cells

 

 

 

Hyperplasia

26

Consequence of persistent hypercalcemia is:

Metastatic calcification

Atherosclerosis

Amyloidosis

Dystrophic calcification

Hemochromatosis

 

 

 

Metastatic calcification

27

 

 

 

Most common form of pathologic calcium

 

 

 

 

Dystrophic type

28

 

Organ most commonly involved in amyloidosis is the:

Kidney 

Heart

Liver

 

 

 

Kidney — action where a lot of amyloid deposition occurs in the glomeruli. 

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