Drug Absorption Flashcards Preview

Fundamentals of Molecular Medicine > Drug Absorption > Flashcards

Flashcards in Drug Absorption Deck (49):
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ADME

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Routes by Which Solutes can Transverse Membrane

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Drug Absorption and Distribution 

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Drug Characterisitics that Favor Diffusion 

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Acid

 

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Base

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Weak Acid/Base

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Weak Acid/Base

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Common Drug Acid/Base Functional Groups

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Acids/Bases Vs. Pka's

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Examples of Weak Acids and Bases

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Weak Acid and Permeability 

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Weak Base and Permeability 

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Henderson Hasselbach Equation 

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What are the most important determinants of moving accross the membrane?

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Importance of Hydrophobicity for Drugs with Similar Pka Values

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Transcapillary Movement 

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Blood Brain Barrier

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Routes for Drug Administration and Elimination 

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IV vs. First Pass Effect

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Why is first pass effect a challenge Clinically?

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Oral Administration Advantages vs. Disadvantages and First pass Metabolism

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Stomach, Small Intestine, Large Intestine

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Sub-Buccal/Sub Lingual Absorption and Absorption Rates

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Paraternal Administration (Lungs) 

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Paraternal Administration (Skin) 

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Intramuscular vs. Subcutaneous

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Intravenous

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Epidural 

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Intrathecal 

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Intraperitoneal

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Routes vs. Time Administration with Cocaine

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Thiopental a lipid soluble anasthetic 

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Major Determinants of Drug Absorption from the Gut

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Placental Fetus/Milk/Uncharged Drugs

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Volume of Distribution 

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Plasma Volume for Different Drugs

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Low vs. High Vd

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Drugs that Bind to Albumin

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Bioavailability

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Drug Metabolism 

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Two Phases of Drug Metabolism 

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Drugs and Phases

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Overdose Toxicity and Acetominophen

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Liver Cytochrome P450 

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Drugs and Age Considerations

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Pharmacogenetics

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pH and Resorbtion 

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