Drug Absorption Flashcards
(49 cards)
1
Q
ADME
A
2
Q
Routes by Which Solutes can Transverse Membrane
A
3
Q
Drug Absorption and Distribution
A
4
Q
Drug Characterisitics that Favor Diffusion
A
5
Q
Acid
A
6
Q
Base
A
7
Q
Weak Acid/Base
A
8
Q
Weak Acid/Base
A
9
Q
Common Drug Acid/Base Functional Groups
A
10
Q
Acids/Bases Vs. Pka’s
A
11
Q
Examples of Weak Acids and Bases
A
12
Q
Weak Acid and Permeability
A
13
Q
Weak Base and Permeability
A
14
Q
A
15
Q
Henderson Hasselbach Equation
A
16
Q
What are the most important determinants of moving accross the membrane?
A
17
Q
Importance of Hydrophobicity for Drugs with Similar Pka Values
A
18
Q
Transcapillary Movement
A
19
Q
Blood Brain Barrier
A
20
Q
Routes for Drug Administration and Elimination
A
21
Q
IV vs. First Pass Effect
A
22
Q
Why is first pass effect a challenge Clinically?
A
23
Q
Oral Administration Advantages vs. Disadvantages and First pass Metabolism
A
24
Q
Stomach, Small Intestine, Large Intestine
A
25
Sub-Buccal/Sub Lingual Absorption and Absorption Rates
26
Paraternal Administration (Lungs)
27
Paraternal Administration (Skin)
28
Intramuscular vs. Subcutaneous
29
Intravenous
30
Epidural
31
Intrathecal
32
Intraperitoneal
33
Routes vs. Time Administration with Cocaine
34
Thiopental a lipid soluble anasthetic
35
Major Determinants of Drug Absorption from the Gut
36
Placental Fetus/Milk/Uncharged Drugs
37
Volume of Distribution
38
Plasma Volume for Different Drugs
39
Low vs. High Vd
40
Drugs that Bind to Albumin
41
Bioavailability
42
Drug Metabolism
43
Two Phases of Drug Metabolism
44
Drugs and Phases
45
Overdose Toxicity and Acetominophen
46
Liver Cytochrome P450
47
Drugs and Age Considerations
48
Pharmacogenetics
49
pH and Resorbtion
