Drug Absorption Flashcards Preview

Fundamentals of Molecular Medicine > Drug Absorption > Flashcards

Flashcards in Drug Absorption Deck (49)
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1
Q

ADME

A
2
Q

Routes by Which Solutes can Transverse Membrane

A
3
Q

Drug Absorption and Distribution

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4
Q

Drug Characterisitics that Favor Diffusion

A
5
Q

Acid

A
6
Q

Base

A
7
Q

Weak Acid/Base

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8
Q

Weak Acid/Base

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9
Q

Common Drug Acid/Base Functional Groups

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10
Q

Acids/Bases Vs. Pka’s

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11
Q

Examples of Weak Acids and Bases

A
12
Q

Weak Acid and Permeability

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13
Q

Weak Base and Permeability

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14
Q
A
15
Q

Henderson Hasselbach Equation

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16
Q

What are the most important determinants of moving accross the membrane?

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17
Q

Importance of Hydrophobicity for Drugs with Similar Pka Values

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18
Q

Transcapillary Movement

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19
Q

Blood Brain Barrier

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20
Q

Routes for Drug Administration and Elimination

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21
Q

IV vs. First Pass Effect

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22
Q

Why is first pass effect a challenge Clinically?

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23
Q

Oral Administration Advantages vs. Disadvantages and First pass Metabolism

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24
Q

Stomach, Small Intestine, Large Intestine

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25
Q

Sub-Buccal/Sub Lingual Absorption and Absorption Rates

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26
Q

Paraternal Administration (Lungs)

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27
Q

Paraternal Administration (Skin)

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28
Q

Intramuscular vs. Subcutaneous

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29
Q

Intravenous

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30
Q

Epidural

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31
Q

Intrathecal

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32
Q

Intraperitoneal

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33
Q

Routes vs. Time Administration with Cocaine

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34
Q

Thiopental a lipid soluble anasthetic

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35
Q

Major Determinants of Drug Absorption from the Gut

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36
Q

Placental Fetus/Milk/Uncharged Drugs

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37
Q

Volume of Distribution

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38
Q

Plasma Volume for Different Drugs

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39
Q

Low vs. High Vd

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40
Q

Drugs that Bind to Albumin

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41
Q

Bioavailability

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42
Q

Drug Metabolism

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43
Q

Two Phases of Drug Metabolism

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44
Q

Drugs and Phases

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45
Q

Overdose Toxicity and Acetominophen

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46
Q

Liver Cytochrome P450

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47
Q

Drugs and Age Considerations

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48
Q

Pharmacogenetics

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49
Q

pH and Resorbtion

A

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