ADME
Routes by Which Solutes can Transverse Membrane
Drug Absorption and Distribution
Drug Characterisitics that Favor Diffusion
Acid
Base
Weak Acid/Base
Weak Acid/Base
Common Drug Acid/Base Functional Groups
Acids/Bases Vs. Pka’s
Examples of Weak Acids and Bases
Weak Acid and Permeability
Weak Base and Permeability
Henderson Hasselbach Equation
What are the most important determinants of moving accross the membrane?
Importance of Hydrophobicity for Drugs with Similar Pka Values
Transcapillary Movement
Blood Brain Barrier
Routes for Drug Administration and Elimination
IV vs. First Pass Effect
Why is first pass effect a challenge Clinically?
Oral Administration Advantages vs. Disadvantages and First pass Metabolism
Stomach, Small Intestine, Large Intestine
Sub-Buccal/Sub Lingual Absorption and Absorption Rates
Paraternal Administration (Lungs)
Paraternal Administration (Skin)
Intramuscular vs. Subcutaneous
Intravenous
Epidural
Intrathecal
Intraperitoneal
Routes vs. Time Administration with Cocaine
Thiopental a lipid soluble anasthetic
Major Determinants of Drug Absorption from the Gut
Placental Fetus/Milk/Uncharged Drugs
Volume of Distribution
Plasma Volume for Different Drugs
Low vs. High Vd
Drugs that Bind to Albumin
Bioavailability
Drug Metabolism
Two Phases of Drug Metabolism
Drugs and Phases
Overdose Toxicity and Acetominophen
Liver Cytochrome P450
Drugs and Age Considerations
Pharmacogenetics
pH and Resorbtion