Drug Absorption Flashcards Preview

Fundamentals of Molecular Medicine > Drug Absorption > Flashcards

Flashcards in Drug Absorption Deck (49):
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ADME

2

 

 

 

Routes by Which Solutes can Transverse Membrane

3

 

 

 

Drug Absorption and Distribution 

4

 

 

 

Drug Characterisitics that Favor Diffusion 

5

 

 

 

 

Acid

 

6

 

 

 

Base

7

 

 

 

Weak Acid/Base

8

 

 

 

Weak Acid/Base

9

 

 

 

Common Drug Acid/Base Functional Groups

10

 

 

 

Acids/Bases Vs. Pka's

11

 

 

 

Examples of Weak Acids and Bases

12

 

 

 

Weak Acid and Permeability 

13

 

 

 

Weak Base and Permeability 

14

 

 

 

 

15

 

 

 

Henderson Hasselbach Equation 

16

 

 

 

What are the most important determinants of moving accross the membrane?

17

 

 

 

Importance of Hydrophobicity for Drugs with Similar Pka Values

18

 

 

 

Transcapillary Movement 

19

 

 

 

Blood Brain Barrier

20

 

 

 

Routes for Drug Administration and Elimination 

21

 

 

 

IV vs. First Pass Effect

22

 

 

 

Why is first pass effect a challenge Clinically?

23

 

 

 

Oral Administration Advantages vs. Disadvantages and First pass Metabolism

24

 

 

 

Stomach, Small Intestine, Large Intestine

25

 

 

 

Sub-Buccal/Sub Lingual Absorption and Absorption Rates

26

 

 

 

Paraternal Administration (Lungs) 

27

 

 

 

Paraternal Administration (Skin) 

28

 

 

 

Intramuscular vs. Subcutaneous

29

 

 

 

Intravenous

30

 

 

 

Epidural 

31

 

 

 

Intrathecal 

32

 

 

 

Intraperitoneal

33

 

 

 

Routes vs. Time Administration with Cocaine

34

 

 

 

Thiopental a lipid soluble anasthetic 

35

 

 

 

Major Determinants of Drug Absorption from the Gut

36

 

 

 

Placental Fetus/Milk/Uncharged Drugs

37

 

 

 

Volume of Distribution 

38

 

 

 

Plasma Volume for Different Drugs

39

 

 

 

Low vs. High Vd

40

 

 

 

Drugs that Bind to Albumin

41

 

 

 

Bioavailability

42

 

 

 

Drug Metabolism 

43

 

 

 

Two Phases of Drug Metabolism 

44

 

 

 

Drugs and Phases

45

 

 

 

Overdose Toxicity and Acetominophen

46

 

 

 

Liver Cytochrome P450 

47

 

 

 

Drugs and Age Considerations

48

 

 

 

Pharmacogenetics

49

 

 

 

pH and Resorbtion 

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