Pharmacokinetics Pt. I Flashcards Preview

Fundamentals of Molecular Medicine > Pharmacokinetics Pt. I > Flashcards

Flashcards in Pharmacokinetics Pt. I Deck (33):
1

 

 

 

What is Pharmacokinetics?

2

 

 

 

Why is pharmacokinetics important?

3

 

 

 

4 Equations

4

 

 

 

One Compartment Model

5

 

 

 

Two Compartment Model

6

 

 

 

Linear Plot of Drug Concentration vs. Time

7

 

 

 

Semi-Log Plot of Drug Concentration vs. Time

8

 

 

 

Apparent Volume of Distribution Equation 

9

 

 

 

Apparent Volume of Distribution Definition 

10

 

 

 

Vd and Tissue vs. Plasma Binding

11

 

 

 

Patients and Vd

12

 

 

 

Parameters for Drug Correction 

13

 

 

 

Skin and Estimating Vd

14

 

 

 

Obese Patients vs. Patients with Edema

15

 

 

 

[Drug] vs. Time and First Order Kinetics

16

 

 

 

Elimination Rate Constant Equation 

17

 

 

 

Drug with 0 Order Kinetics 

18

 

 

 

First Order Kinetics vs. Saturating Kinetics (0 Order Kinetics)

19

 

 

 

Clearance Equation 

20

 

 

 

Definition of Clearance

21

 

 

 

Fast Acetylators vs. Slow Acetylators

22

 

 

 

Affect of Clearance on Age

23

 

 

 

Bioavailability Equation 

24

 

 

 

Definition of Bioavailability 

25

 

 

 

3 Important Parameters of Oral Drug Concentration 

26

 

 

 

Bioequivalence 

27

 

 

 

Bioequivalence vs. Bioavailability 

28

 

 

 

Absorption and Half Life

29

 

 

 

Approach to Solving PK Problems

30

31

32

 

 

 

Determine Vd and K

33

 

 

 

Clearance Definition 

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