Generation of Diversity Flashcards by Omar Saqr

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Q

Clonal Selection

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Q

How many gene families are there?

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Q

How are V-Regions different in assembly than Constant Regions?

How are different regions coded for?

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Light Chain Gene Rearrangements

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Stepwise Light Chain Rearrangements:

Germline DNA

Rearranged DNA
Primary RNA Transcript

mRNA

PolyPeptide Chain

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Heavy Chain Rearrangments

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Stepwise Heavy Chain Rearrangements:

Germline DNA

Rearranged DNA
Primary RNA Transcript

mRNA

PolyPeptide Chain

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Q

Heavy Chain Locus

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Kappa Light Chain Locus

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Lamda Light Chain Locus

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Heavy Chain Rearrangements in two different B-Cell Clones

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Immunoglobulin Heavy and Light Chain Loci

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Random Recombination of Gene Segments

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Junctional Diversity

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Q

Schematic of V-J Recombination

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Q

Junctional Diversity

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Q

Potential Repitoire

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Q

Diversity of CDR’s

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Allelic Exclusion

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Q

Southern Blott

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PCR Primers

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Characterization of Junctional Genes

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Q

When Does Somatic Hypermutation Occur?

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Somatic Hypermutation

AID

AID and the Process of Somatic Hypermutation

Somatic Hypermutation and Secondary Response

T-Cell Origin

T-Cell Receptor vs. B-Cell

Classes of T-Cell

TCR Locus

Recombination in T-Cells

RAG Deficiency

TCR Junctional Diversitu

TCell Repitoire

Light Chain DNA Gene Rearrangement (Only heavy chains undergo class switching) B is the answer