Cell Movement and the Cytoskeleton Flashcards Preview

Fundamentals of Molecular Medicine > Cell Movement and the Cytoskeleton > Flashcards

Flashcards in Cell Movement and the Cytoskeleton Deck (60):
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Objectives

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Why should a physician care about cell movement

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The Cytoskeleton 

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Cytoskeletal Proteins

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Cytoskeletal Functions

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What is the green?

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What are Microtubules

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Microtubule Structure

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Video of Microtubules

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Lysosomes and Endosomes Revisited

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Kinesins vs. Dyneins

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Centrioles

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Mitotic Spindle

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Name 3 Drugs that Affect Microtubule function

 

 

1. Colchicine

2. Vinblastine

3. Taxol

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Colchicine

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Vineblastine

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Taxol 

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Cilia Structure and Function 

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Primary Cilliary Dyskinesia

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Microfilament Structure

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Polymorphism of Microtubules

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Microfilaments and Cytoskeleton

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Microvilli vs. Cillia

 

 

Microvilli — shorter than cilia and immobile. Their core protein of Microfilaments

Cilia — core protein of microtubules — actively moved by the cell

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Cell Division and Microtubules vs. Microfilaments

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Name 2 Drugs that Affect Microfilament Function 

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Cytochalasins 

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Phalloidin 

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Intermediate Filaments Structure and Function 

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Type I intermediate Filaments

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Type II Intermediate Fillaments

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Type III Intermediate Filaments 

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Type IV Intermediate Filaments

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Type V Intermediate Filaments

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Intermediate Filaments and Structural Integrity 

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Skin Cells Stained for Keratin

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Epidermolytic Bullosa Simplex (EBS)

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EBS Mutation 

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Epidermolytic Hyperkeratosis 

 

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Epidermolytic Palmoplantar Keratoderma

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Hypertrophic Cardiomyopathy 

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Motor Neuron Disease

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NF-H Overexpression 

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47

Taxol is used to treat which of the following?

Broken Bones

Cancer

Atrophy of Muscle

Viral Infections

Bacterial Infections

 

 

 

Cancer

48

Which of these are involved in chromosome movement during mitosis and meiosis?

Microtubules

Intermediate filaments

Microfilaments

 

 

 

Microtubules

49

Which of these are involved in cytokinesis?

Microtubules

Intermediate filaments

Microfilaments

 

 

 

Microfilaments

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What is the diameter and polarity of microtubules?

50nm Plar

50 nm Non polar

25nm Polar

 

 

 

25nm Polar

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Which is true regarding cytoskeletal Elements and subunits?

Most cytoskeletal proteins are part of the network

Most cytoskeletal proteins are soluble subunits

There is a balance between network and soluble subunits in the cell. 

 

 

There is a balance between network and soluble subunits in the cell. 

52

Cytoskeletal elementas have a wide variety of functions much of this variety of function can be explained by?

Different core subunits in each element

Polarity of each element

The protein associated with each element

Availability of ATP to each Element

 

 

 

The protein associated with each element

53

Genetic defects in keratin genes leads to which of the following?

Cardiomyopathy

Mental Retardation

Hepatitis

Early onset diabetes

Skin blistering of newborns

 

 

 

Skin blistering of newborns

54

If you had a sample of tumor from a patient and whereintereste in knowing the origin of the tumor cells an antibody to which protein family would be most helpful?

Microtubules

Intermediate Filaments

Microfilaments

 

 

 

Intermediate Filaments

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Which of these are the “Tracks” on which cellular vesicles travel?

Microtubules

Intermediate Filaments

Microfilaments

 

 

 

Microtubules

56

What is the diameter and polarity of intermediate filaments?

 

10 nm Polar

10nm Non Polar 

 

 

 

10nm Non Polar 

57

Which of the following describing the microtubule organizing center is correct?

Near golgi associated with the minus end of microtubules

Near golgi associated with the plus end

Near nucleus associated with the minus end of the microtubules

Near the nucleus associated with the plus end of the microtubules

 

 

Near golgi associated with the minus end of microtubules

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In this image green is staining for tubular the red dot is which of the following?

Centriole

Filopdia

Mitochondria

The endoplasmic reticulum 

 

 

 

Centriole

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What is the diameter and polarity of microfilaments?

 

 

 

 

5nm Polar

60

Which of the following forms the core protein in cillia

Microtubules

Intermediate Filaments

Microfilaments

 

 

 

Microtubules

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