Cell Movement and the Cytoskeleton

Question 1

Objectives

Answer 1

Question 2

Why should a physician care about cell movement

Answer 2

Question 3

The Cytoskeleton

Answer 3

Question 4

Cytoskeletal Proteins

Answer 4

Question 5

Cytoskeletal Functions

Answer 5

Question 6

What is the green?

Answer 6

Question 7

What are Microtubules

Answer 7

Question 8

Microtubule Structure

Answer 8

Question 9

Video of Microtubules

Answer 9

Question 10

Lysosomes and Endosomes Revisited

Answer 10

Question 11

Kinesins vs. Dyneins

Answer 11

Question 12

Centrioles

Answer 12

Question 13

Mitotic Spindle

Answer 13

Question 14

Name 3 Drugs that Affect Microtubule function

Answer 14

1. Colchicine
2. Vinblastine
3. Taxol

Question 15

Colchicine

Answer 15

Question 16

Vineblastine

Answer 16

Question 17

Taxol

Answer 17

Question 18

Cilia Structure and Function

Answer 18

Question 19

Answer 19

Question 20

Primary Cilliary Dyskinesia

Answer 20

Question 21

Answer 21

Question 22

Microfilament Structure

Answer 22

Question 23

Polymorphism of Microtubules

Answer 23

Question 24

Microfilaments and Cytoskeleton

Answer 24

Question 25

Answer 25

Question 26

Microvilli vs. Cillia

Answer 26

Microvilli — shorter than cilia and immobile. Their core protein of Microfilaments Cilia — core protein of microtubules — actively moved by the cell

Question 27

Cell Division and Microtubules vs. Microfilaments

Answer 27

Question 28

Name 2 Drugs that Affect Microfilament Function

Answer 28

Question 29

Cytochalasins

Answer 29

Question 30

Phalloidin

Answer 30

Question 31

Intermediate Filaments Structure and Function

Answer 31

Question 32

Type I intermediate Filaments

Answer 32

Question 33

Type II Intermediate Fillaments

Answer 33

Question 34

Type III Intermediate Filaments

Answer 34

Question 35

Type IV Intermediate Filaments

Answer 35

Question 36

Type V Intermediate Filaments

Answer 36

Question 37

Intermediate Filaments and Structural Integrity

Answer 37

Question 38

Answer 38

Question 39

Skin Cells Stained for Keratin

Answer 39

Question 40

Epidermolytic Bullosa Simplex (EBS)

Answer 40

Question 41

EBS Mutation

Answer 41

Question 42

Epidermolytic Hyperkeratosis

Answer 42

Question 43

Epidermolytic Palmoplantar Keratoderma

Answer 43

Question 44

Hypertrophic Cardiomyopathy

Answer 44

Question 45

Motor Neuron Disease

Answer 45

Question 46

NF-H Overexpression

Answer 46

Question 47

Taxol is used to treat which of the following? ## Footnote Broken Bones Cancer Atrophy of Muscle Viral Infections Bacterial Infections

Answer 47

Cancer

Question 48

Which of these are involved in chromosome movement during mitosis and meiosis? Microtubules Intermediate filaments Microfilaments

Answer 48

Microtubules

Question 49

Which of these are involved in cytokinesis? Microtubules Intermediate filaments Microfilaments

Answer 49

Microfilaments

Question 50

What is the diameter and polarity of microtubules? 50nm Plar 50 nm Non polar 25nm Polar

Answer 50

25nm Polar

Question 51

Which is true regarding cytoskeletal Elements and subunits? Most cytoskeletal proteins are part of the network Most cytoskeletal proteins are soluble subunits There is a balance between network and soluble subunits in the cell.

Answer 51

There is a balance between network and soluble subunits in the cell.

Question 52

Cytoskeletal elementas have a wide variety of functions much of this variety of function can be explained by? ## Footnote Different core subunits in each element Polarity of each element The protein associated with each element Availability of ATP to each Element

Answer 52

The protein associated with each element

Question 53

Genetic defects in keratin genes leads to which of the following? ## Footnote Cardiomyopathy Mental Retardation Hepatitis Early onset diabetes Skin blistering of newborns

Answer 53

Skin blistering of newborns

Question 54

If you had a sample of tumor from a patient and whereintereste in knowing the origin of the tumor cells an antibody to which protein family would be most helpful? Microtubules Intermediate Filaments Microfilaments

Answer 54

Intermediate Filaments

Question 55

## Footnote Which of these are the “Tracks” on which cellular vesicles travel? Microtubules Intermediate Filaments Microfilaments

Answer 55

Microtubules

Question 56

What is the diameter and polarity of intermediate filaments? 10 nm Polar 10nm Non Polar

Answer 56

10nm Non Polar

Question 57

Which of the following describing the microtubule organizing center is correct? Near golgi associated with the minus end of microtubules Near golgi associated with the plus end Near nucleus associated with the minus end of the microtubules Near the nucleus associated with the plus end of the microtubules

Answer 57

Near golgi associated with the minus end of microtubules

Question 58

In this image green is staining for tubular the red dot is which of the following? Centriole Filopdia Mitochondria The endoplasmic reticulum

Answer 58

Centriole

Question 59

What is the diameter and polarity of microfilaments?

Answer 59

5nm Polar

Question 60

Which of the following forms the core protein in cillia Microtubules Intermediate Filaments Microfilaments

Answer 60

Microtubules