Cell Movement and the Cytoskeleton Flashcards Preview

Fundamentals of Molecular Medicine > Cell Movement and the Cytoskeleton > Flashcards

Flashcards in Cell Movement and the Cytoskeleton Deck (60):
1

 

 

 

Objectives

2

 

 

 

Why should a physician care about cell movement

3

 

 

 

The Cytoskeleton 

4

 

 

 

Cytoskeletal Proteins

5

 

 

 

Cytoskeletal Functions

6

 

 

 

What is the green?

7

 

 


What are Microtubules

8

 

 

 

Microtubule Structure

9

 

 

 

Video of Microtubules

10

 

 

 

Lysosomes and Endosomes Revisited

11

 

 

 

Kinesins vs. Dyneins

12

 

 

 

Centrioles

13

 

 

 

Mitotic Spindle

14

 

 

 

Name 3 Drugs that Affect Microtubule function

 

 

1. Colchicine

2. Vinblastine

3. Taxol

15

 

 

 

Colchicine

16

 

 

 

Vineblastine

17

 

 

 

Taxol 

18

 

 

 

Cilia Structure and Function 

19

 

 

 

 

20

 

 

 

Primary Cilliary Dyskinesia

21

22

 

 

 

Microfilament Structure

23

 

 

 

Polymorphism of Microtubules

24

 

 

 

Microfilaments and Cytoskeleton

25

26

 

 

 

Microvilli vs. Cillia

 

 

Microvilli — shorter than cilia and immobile. Their core protein of Microfilaments

Cilia — core protein of microtubules — actively moved by the cell

27

 

 

 

Cell Division and Microtubules vs. Microfilaments

28

 

 

 

Name 2 Drugs that Affect Microfilament Function 

29

 

 

 

Cytochalasins 

30

 

 

 

Phalloidin 

31

 

 

 

Intermediate Filaments Structure and Function 

32

 

 

 

Type I intermediate Filaments

33

 

 

 

Type II Intermediate Fillaments

34

 

 

 

Type III Intermediate Filaments 

35

 

 

 

Type IV Intermediate Filaments

36

 

 

 

Type V Intermediate Filaments

37

 

 

 

Intermediate Filaments and Structural Integrity 

38

 

 

 

 

39

 

 

 

Skin Cells Stained for Keratin

40

 

 

 

Epidermolytic Bullosa Simplex (EBS)

41

 

 

 

EBS Mutation 

42

 

 

 

 

Epidermolytic Hyperkeratosis 

 

43

 

 

 

Epidermolytic Palmoplantar Keratoderma

44

 

 

 

Hypertrophic Cardiomyopathy 

45

 

 

 

Motor Neuron Disease

46

 

 

 

NF-H Overexpression 

47

Taxol is used to treat which of the following?

Broken Bones

Cancer

Atrophy of Muscle

Viral Infections

Bacterial Infections

 

 

 

Cancer

48

Which of these are involved in chromosome movement during mitosis and meiosis?

Microtubules

Intermediate filaments

Microfilaments

 

 

 

Microtubules

49

Which of these are involved in cytokinesis?

Microtubules

Intermediate filaments

Microfilaments

 

 

 

Microfilaments

50

 

 

What is the diameter and polarity of microtubules?

50nm Plar

50 nm Non polar

25nm Polar

 

 

 

25nm Polar

51

 

Which is true regarding cytoskeletal Elements and subunits?

Most cytoskeletal proteins are part of the network

Most cytoskeletal proteins are soluble subunits

There is a balance between network and soluble subunits in the cell. 

 

 

There is a balance between network and soluble subunits in the cell. 

52

Cytoskeletal elementas have a wide variety of functions much of this variety of function can be explained by?

Different core subunits in each element

Polarity of each element

The protein associated with each element

Availability of ATP to each Element

 

 

 

The protein associated with each element

53

Genetic defects in keratin genes leads to which of the following?

Cardiomyopathy

Mental Retardation

Hepatitis

Early onset diabetes

Skin blistering of newborns

 

 

 

Skin blistering of newborns

54

If you had a sample of tumor from a patient and whereintereste in knowing the origin of the tumor cells an antibody to which protein family would be most helpful?

Microtubules

Intermediate Filaments

Microfilaments

 

 

 

Intermediate Filaments

55

 

Which of these are the “Tracks” on which cellular vesicles travel?

Microtubules

Intermediate Filaments

Microfilaments

 

 

 

Microtubules

56

What is the diameter and polarity of intermediate filaments?

 

10 nm Polar

10nm Non Polar 

 

 

 

10nm Non Polar 

57

Which of the following describing the microtubule organizing center is correct?

Near golgi associated with the minus end of microtubules

Near golgi associated with the plus end

Near nucleus associated with the minus end of the microtubules

Near the nucleus associated with the plus end of the microtubules

 

 

Near golgi associated with the minus end of microtubules

58

In this image green is staining for tubular the red dot is which of the following?

Centriole

Filopdia

Mitochondria

The endoplasmic reticulum 

 

 

 

Centriole

59

 

 

 

What is the diameter and polarity of microfilaments?

 

 

 

 

5nm Polar

60

Which of the following forms the core protein in cillia

Microtubules

Intermediate Filaments

Microfilaments

 

 

 

Microtubules

Decks in Fundamentals of Molecular Medicine Class (77):