Phospholipid and Glycolipid Metabolism Flashcards Preview

Fundamentals of Molecular Medicine > Phospholipid and Glycolipid Metabolism > Flashcards

Flashcards in Phospholipid and Glycolipid Metabolism Deck (34):
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Lipid Nomenclature

3

 

 

 

Roles of Phospholipids

4

 

 

 

Glycerophospholipids

5

Glycerol 3 phosphate is produced from which of the following outside of the liver?

Glycerol

Glyceraldehyde 3 Phosphate

Dihydroxyacetone phosphate 

Pyruvate

Lactate

 

 

 

Dihydroxyacetone phosphate — This is how G3P is made outside the liver. 

6

 

 

 

Phosphatidic Acid

7

 

 

 

Sphingolipids

8

 

 

 

Types of Sphingolipids

9

 

 

 

Phospholipid Structures

10

 

 

 

Cerebroside Structures

11

 

 

 

Ganglioside Structure

12

GM1(a ganglioside) Can be best described bt which one of the following terms?

 

Glycerophospholipid

Cerebroside — only one sugar not two

Phospholipid — there’s no phosphate so its not this.

Diglyceride 

Glycolipid 

 

 

 

Glycolipid — lipid to which sugars are attached. (A better term would be glycosphingolipid) 

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Phospholipid Metabolism 

14

 

 

 

Phospholipid Structures

Phosphatidylcholine and Phosphatidylethanolamine

15

 

 

 

More Phospholipid Structures:

Phosphatidylserine and phosphatidylinositol

16

 

 

 

Even More Phospholipid Structures:

Phosphatidyl Glycerol and Cardiolipin

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Structures of Phosphatidic Acid and Sphingomyelin

18

 

 

 

Phospholipid Nomenclature

19

 

 

 

More Phospholipid Nomeclature

20

 

 

 

Simplified View of Phospholipid Synthesis 

21

 

 

 

Partial Rationale for Phospholipid Synthesis 

22

Which tissue will utilize the glycerol pathway?

Brain 

Red Blood Cell

Intestine 

Liver

Muscle 

 

 

 

Liver — only the liver has glycerol kinase so only the liver can use glycerol to get to phospholipid synthesis. 

23

What other pathway utilizes a head group activation process?

Glycolysis 

Glycogen synthesis

Glycogenolysis

HMP Shunt

Fatty Acid Degradation 

 

 

 

Glycogen synthesis

24

Individual has a primary carnitine deficiency. Triglyceride synthesis in the liver would be expected to be which one of the following compared to an individual with no carnitine deficiency?

Increased 

Decreased

Same

 

 

 

Increased 

25

 

 

 

Role of Plasmalogens

26

Mitochondrial Function may be compromised by which disorder?

Typ 1 Diabetes

Type 2 Diabetes

Zellwedgers Syndrome 

Galactosemia

Fructokinase Deficiency 

Pompe Diseases

 

 

 

Zellwedgers Syndrome — lack of peroxisomes. 

27

Zellwedgers syndrome would lead to an accumulation of which one of the following?

Bicarboxilc acids

Branched Chain Fatty Acids

Propionyl CoA

Carnitine

 

 

 

Branched Chain Fatty Acids

28

 

 

 

Biosynthesis of Sphingosine

29

Vitamin B6 was also required for which one of the following enzymes?

Glycogen Synthase 

Glycogen Phosphorylase 

Pyruvate dehydrogenase 

Isocitrate Dehydrogenase 

Transketolase 

 

Glycogen Synthase — No cofactors required

Glycogen Phosphorylase — Requires B6

Pyruvate dehydrogenase — Requires the big 5

Isocitrate Dehydrogenase — requires NAD

Transketolase — Requires B1

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Synthesis of Ceramide

31

 

 

 

Biosynthesis of Sphingomyelin 

32

 

 

 

Sphingomyelin Degredation 

33

 

 

 

Glycerophospholipid Degredation 

34

 

 

 

Ganglioside Function 

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