Phospholipid and Glycolipid Metabolism Flashcards Preview

Fundamentals of Molecular Medicine > Phospholipid and Glycolipid Metabolism > Flashcards

Flashcards in Phospholipid and Glycolipid Metabolism Deck (34):
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Lipid Nomenclature

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Roles of Phospholipids

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Glycerophospholipids

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Glycerol 3 phosphate is produced from which of the following outside of the liver?

Glycerol

Glyceraldehyde 3 Phosphate

Dihydroxyacetone phosphate 

Pyruvate

Lactate

 

 

 

Dihydroxyacetone phosphate — This is how G3P is made outside the liver. 

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Phosphatidic Acid

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Sphingolipids

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Types of Sphingolipids

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Phospholipid Structures

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Cerebroside Structures

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Ganglioside Structure

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GM1(a ganglioside) Can be best described bt which one of the following terms?

 

Glycerophospholipid

Cerebroside — only one sugar not two

Phospholipid — there’s no phosphate so its not this.

Diglyceride 

Glycolipid 

 

 

 

Glycolipid — lipid to which sugars are attached. (A better term would be glycosphingolipid) 

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Phospholipid Metabolism 

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Phospholipid Structures

Phosphatidylcholine and Phosphatidylethanolamine

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More Phospholipid Structures:

Phosphatidylserine and phosphatidylinositol

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Even More Phospholipid Structures:

Phosphatidyl Glycerol and Cardiolipin

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Structures of Phosphatidic Acid and Sphingomyelin

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Phospholipid Nomenclature

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More Phospholipid Nomeclature

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Simplified View of Phospholipid Synthesis 

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Partial Rationale for Phospholipid Synthesis 

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Which tissue will utilize the glycerol pathway?

Brain 

Red Blood Cell

Intestine 

Liver

Muscle 

 

 

 

Liver — only the liver has glycerol kinase so only the liver can use glycerol to get to phospholipid synthesis. 

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What other pathway utilizes a head group activation process?

Glycolysis 

Glycogen synthesis

Glycogenolysis

HMP Shunt

Fatty Acid Degradation 

 

 

 

Glycogen synthesis

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Individual has a primary carnitine deficiency. Triglyceride synthesis in the liver would be expected to be which one of the following compared to an individual with no carnitine deficiency?

Increased 

Decreased

Same

 

 

 

Increased 

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Role of Plasmalogens

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Mitochondrial Function may be compromised by which disorder?

Typ 1 Diabetes

Type 2 Diabetes

Zellwedgers Syndrome 

Galactosemia

Fructokinase Deficiency 

Pompe Diseases

 

 

 

Zellwedgers Syndrome — lack of peroxisomes. 

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Zellwedgers syndrome would lead to an accumulation of which one of the following?

Bicarboxilc acids

Branched Chain Fatty Acids

Propionyl CoA

Carnitine

 

 

 

Branched Chain Fatty Acids

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Biosynthesis of Sphingosine

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Vitamin B6 was also required for which one of the following enzymes?

Glycogen Synthase 

Glycogen Phosphorylase 

Pyruvate dehydrogenase 

Isocitrate Dehydrogenase 

Transketolase 

 

Glycogen Synthase — No cofactors required

Glycogen Phosphorylase — Requires B6

Pyruvate dehydrogenase — Requires the big 5

Isocitrate Dehydrogenase — requires NAD

Transketolase — Requires B1

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Synthesis of Ceramide

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Biosynthesis of Sphingomyelin 

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Sphingomyelin Degredation 

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Glycerophospholipid Degredation 

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Ganglioside Function 

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