Urea Cycle Flashcards Preview

Fundamentals of Molecular Medicine > Urea Cycle > Flashcards

Flashcards in Urea Cycle Deck (33):
1

 

 

 

Urea Cycle Big Picture

A image thumb
2

 

 

 

3 Transaminations

A image thumb
3

 

 

 

Vitamin B6 and AA Metabolism 

A image thumb
4

What other enzyme requires vitamin b6?

Glucokinase

Glycogen Phosphorylase

Pyruvate Dehydrogenase

G6P dehaydrogenas

Fatty Ayl CoA Synthetase

 

 

 

Glycogen Phosphorylase

5

Muscle Degredation of Protein Will Occur under which of the following Conditions?

After a high fat low carb meal

During prolonged fasting

After a high carb low protein meal

During shorter anaerobic exercise

 

 

After a high fat low carb meal — This might be accepted much further downstream. 

During prolonged fasting

6

 

 

 

Muscle Degredation of Amino Acids

A image thumb
7

 

 

 

Ammonia Metabolism in Liver

A image thumb
8

 

 

 

Enzymes involved in Nitrogen Metabolism

A image thumb
9

 

 

 

Flow of Nitrogen 

A image thumb
10

 

 

 

Glutamine Synthetase

 

 

 

Glutamine Synthetas is found in the cytoplasm.

A image thumb
11

 

 

 

Glutaminase

 

 

 

So is Glutaminase (found in the cytosol).

A image thumb
12

 

 

 

Glutamate Dehydrogenase

A image thumb
13

 

 

 

Why is Ammonia Toxic?

A image thumb
14

 

 

 

Nervous System and Amino Acids

A image thumb
15

 

 

 

Synthesis of Carbamoyl Phosphate

A image thumb
16

 

 

 

Urea Cycle Pathway 

A image thumb
17

 

 

 

Compartmentation in the Urea Cycle

A image thumb
18

 

 

 

TCA Urea Cycle Interactions

A image thumb
19

 

 

 

Where does Ornithine Come From?

A image thumb
20

 

 

 

Regulation of the Urea Cycle

A image thumb
21

What other pathway exhibited long term adaptation?

Glycolysis

Gluconeogenesis

Fatty acid Syntehisis

Fatty Acid Oxidation 

 

 

 

Fatty acid Syntehisis

22

 

 

 

Allosteric Regulation of the Urea Cycle

A image thumb
23

 

 

 

Pathway for Regulation of Urea Cycle

A image thumb
24

 

 

 

N-Acetyl Glutamate Synthetase Deficiency and CPS- Deficiency

A image thumb
25

 

 

 

Ornithine Transcarbamoylase Deficiency

A image thumb
26

 

 

 

Continued Disorders of the Urea Cycle

A image thumb
27

 

 

 

Arginase Defect

A image thumb
28

Potential Treatment for urea cycle disorders could include which of the following?

Take aspirin

Taking essential amino acids

Taking Alpha keto acids of essential amino acids 

Increasing the protein content of diet

Decreasing Carbohydrate Intake

 

 

Taking Alpha keto acids of essential amino acids — leads to reduced ammonia levels. 

29

 

 

 

Treatment for Urea Cycle Disorders

A image thumb
30

 

 

 

Hypercitrullinemia Type II

A image thumb
31

 

 

 

Nitrogen Balance

A image thumb
32

 

 

 

Case Study

Q image thumb

 

 

 

Ornithine Transcarbamylase deficiency 

33

 

A Healthy individualstarts a diet which had adequate calories but lacks one essential amino acid. What happens to their nitrogen balance?

Neutral Nitrogen Balance

Positive Nitrogen Balance

Negative Nitrogen Balance

 

 

 

Negative Nitrogen Balance

Decks in Fundamentals of Molecular Medicine Class (77):