Urea Cycle Flashcards Preview

Fundamentals of Molecular Medicine > Urea Cycle > Flashcards

Flashcards in Urea Cycle Deck (33):
1

 

 

 

Urea Cycle Big Picture

2

 

 

 

3 Transaminations

3

 

 

 

Vitamin B6 and AA Metabolism 

4

What other enzyme requires vitamin b6?

Glucokinase

Glycogen Phosphorylase

Pyruvate Dehydrogenase

G6P dehaydrogenas

Fatty Ayl CoA Synthetase

 

 

 

Glycogen Phosphorylase

5

Muscle Degredation of Protein Will Occur under which of the following Conditions?

After a high fat low carb meal

During prolonged fasting

After a high carb low protein meal

During shorter anaerobic exercise

 

 

After a high fat low carb meal — This might be accepted much further downstream. 

During prolonged fasting

6

 

 

 

Muscle Degredation of Amino Acids

7

 

 

 

Ammonia Metabolism in Liver

8

 

 

 

Enzymes involved in Nitrogen Metabolism

9

 

 

 

Flow of Nitrogen 

10

 

 

 

Glutamine Synthetase

 

 

 

Glutamine Synthetas is found in the cytoplasm.

11

 

 

 

Glutaminase

 

 

 

So is Glutaminase (found in the cytosol).

12

 

 

 

Glutamate Dehydrogenase

13

 

 

 

Why is Ammonia Toxic?

14

 

 

 

Nervous System and Amino Acids

15

 

 

 

Synthesis of Carbamoyl Phosphate

16

 

 

 

Urea Cycle Pathway 

17

 

 

 

Compartmentation in the Urea Cycle

18

 

 

 

TCA Urea Cycle Interactions

19

 

 

 

Where does Ornithine Come From?

20

 

 

 

Regulation of the Urea Cycle

21

What other pathway exhibited long term adaptation?

Glycolysis

Gluconeogenesis

Fatty acid Syntehisis

Fatty Acid Oxidation 

 

 

 

Fatty acid Syntehisis

22

 

 

 

Allosteric Regulation of the Urea Cycle

23

 

 

 

Pathway for Regulation of Urea Cycle

24

 

 

 

N-Acetyl Glutamate Synthetase Deficiency and CPS- Deficiency

25

 

 

 

Ornithine Transcarbamoylase Deficiency

26

 

 

 

Continued Disorders of the Urea Cycle

27

 

 

 

Arginase Defect

28

Potential Treatment for urea cycle disorders could include which of the following?

Take aspirin

Taking essential amino acids

Taking Alpha keto acids of essential amino acids 

Increasing the protein content of diet

Decreasing Carbohydrate Intake

 

 

Taking Alpha keto acids of essential amino acids — leads to reduced ammonia levels. 

29

 

 

 

Treatment for Urea Cycle Disorders

30

 

 

 

Hypercitrullinemia Type II

31

 

 

 

Nitrogen Balance

32

 

 

 

Case Study

 

 

 

Ornithine Transcarbamylase deficiency 

33

 

A Healthy individualstarts a diet which had adequate calories but lacks one essential amino acid. What happens to their nitrogen balance?

Neutral Nitrogen Balance

Positive Nitrogen Balance

Negative Nitrogen Balance

 

 

 

Negative Nitrogen Balance

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