What ab’s activate complement?
Effector Functions of Complement
Physiological Activities of Complement
Opsonization by C3B
Immune Adherence vs. Opsonization
What mechanism protects against tetanus Toxin?
Neutralization
What is the major role of complement?
Major Role of Complement is actually inflammation not the lysis aspect
Anaphylatoxins
activate mast cells to release histamines
What is the most powerful attractant for Neutrophils?
C5a is the most powerful attractant for neutrophils
What is an important aspect of F-Met in bacteria?
F-Met is another attractant
What is the role of Anaphylatoxins?
3 Major Roles of Complement
C3 Convertase
Common to both Alternate and Classical Pathway of Complement?
Describe the function of C3 Convertase
How is C5 Convertase made and what is it’s function?
What opsonins are part of the MAC Complex?
Overview of Formation of MAC
Roles of C5-C9
Don’t memorize just Read.
Desribe the overall pathway that is common to complement
1st Step of the Classical Pathway
2nd Step of the Classical Pathway
Complement Fixation
Describe the Steps of the Alternate Pathway
Stabilization of Alternate C3 Convertase
Properdin
Overview of All 3 Pathways
Comparision of All 3 Pathways
C1 Esterase Inhibitor
and
Decay Accelerating Factor
Deficiencies in Classical Pathway
DAF Deficiency
C3 Deficiency
and C5-C8 Deficiency
Peroxysmal Nocturnal Hemoglobinuria
Table of Complement Proteins and Effects of their Deficiency
Overview of Complement showing where DAF and C1Esterase deficiencies are
Answer the Following Questions
True or False