Fibrous Proteins Flashcards Preview

Fundamentals of Molecular Medicine > Fibrous Proteins > Flashcards

Flashcards in Fibrous Proteins Deck (53):
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Fibrous Protein

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Collagen 

3

 

 

 

Collagen and Collagen Related Diseases

4

 

 

 

What is the Pathology?

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Pathology?

6

 

 

 

Pathology?

7

 

 

 

Pathology?

8

9

10

 

 

 

Mutation Underlying Osteogenesis Imperfecta

11

 

 

 

Levels of Collagen Structure

12

 

 

 

Collagen Role in Bone Formation 

13

 

 

 

Levels of Collagen Structure Models

14

 

 

 

Collagen Primary Structure

15

 

 

 

Hydroxyproline

16

 

 

 

Collagen Primary Structure and Interchain Hydrogen Bonding 

17

 

 

 

Model of Tripple Helix

18

 

 

 

Stabilizing the Triple Helix

19

 

 

 

Roles of Hydroxyproline

20

 

 

 

Collagen Synthesis 

21

 

 

 

Steps in Collagen Biosynthesis 

22

 

 

 

Function of Collagen Pro-Peptides

23

 

 

 

Collagen Pro-Peptides

24

 

 

 

Collagen Biosynthesis from transcription to formation 

25

 

 

 

Hydroxylation of Lysine

26

 

 

 

Hydroxylation of Proline

27

 

 

 

Why is Ascorbate acid essential in Collagen Biosynthesis

28

 

 

 

Role of Hydroxyproline 

29

 

 

 

Lysine and Proline Hydroxylases

30

 

 

 

Scurvy

31

 

 

 

Cross-Link Formation in Collagen 

32

 

 

 

Post translational modification in lysine crosslink formation 

33

 

 

 

One type of Cross-Link Seen in Collagen 

34

 

 

 

Collagen Disorders

35

 

 

 

Elastin 

36

 

 

 

What is Elastin 

37

 

 

 

Major differences between Collagen and Elastin 

38

 

 

 

Williams Syndrome and Supravalvular Aortic Stenosis 

39

40

 

 

 

Elastin Primary Structure

41

 

 

 

Elastin Biosynthesis from transcription to formation 

42

 

 

 

Entropy Driven Elastic Recoil

43

 

 

 

Elastin Open and Closed State

44

 

 

 

Elastin Stretching the Limits

45

 

 

 

Desmosine

46

 

 

 

Building Elastin 

47

 

 

 

Fibrillin and Fibulin

48

 

 

 

Fibrillin 1 Secretion 

49

 

 

 

Marfan's Syndrome

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Conclusion 

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