Trapping a Weakly Basic
Henderson Hasselbach Equation
Where is Aspirin, a weak acid, absorbed and why?
Where is a Chlorodiazepoxide, a weak base, absorbed and why?
ADME graph at different pH’s
Observations on Drug administration and compartmentalization
Examples of Compartments
pH of Selected Body Fluids
Quantitative Drug Distribution Problems
Definition of Acid/Base
Ibuprofin
(Weak Acid pKa = 4.4)
Where will Ibuprofin be efficiently absorbed?
Drug Partitioning Problems for Weak Acids
Drug Partioning Problems for Weak Bases
Special Case of weak acid with very basic PKa
or
Weak Base with very acidic PKa
Adjusting pH to trap drug in urine
Adjusting Urine pH and effect on Clearance for weak acids
Adjusting pH and Clearance of Weak Bases
Real World Example of Drug Clearance
None of the Above
4
Option #4
Option 3
Option 4
Option 6
Option 1
Option 2 (0.1)
Option 3 (1)
Figure it out
?
Figure it out