Drug Absorption Pt. II Flashcards Preview

Fundamentals of Molecular Medicine > Drug Absorption Pt. II > Flashcards

Flashcards in Drug Absorption Pt. II Deck (35)
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1
Q

Trapping a Weakly Basic

A
2
Q

Henderson Hasselbach Equation

A
3
Q

Where is Aspirin, a weak acid, absorbed and why?

A
4
Q

Where is a Chlorodiazepoxide, a weak base, absorbed and why?

A
5
Q

ADME graph at different pH’s

A
6
Q

Observations on Drug administration and compartmentalization

A
7
Q

Examples of Compartments

A
8
Q

pH of Selected Body Fluids

A
9
Q
A
10
Q

Quantitative Drug Distribution Problems

A
11
Q

Definition of Acid/Base

A
12
Q
A
13
Q
A
14
Q

Ibuprofin

(Weak Acid pKa = 4.4)

A
15
Q

Where will Ibuprofin be efficiently absorbed?

A
16
Q

Drug Partitioning Problems for Weak Acids

A
17
Q

Drug Partioning Problems for Weak Bases

A
18
Q

Special Case of weak acid with very basic PKa

or

Weak Base with very acidic PKa

A
19
Q

Adjusting pH to trap drug in urine

A
20
Q
A
21
Q

Adjusting Urine pH and effect on Clearance for weak acids

A
22
Q

Adjusting pH and Clearance of Weak Bases

A
23
Q

Real World Example of Drug Clearance

A
24
Q
A

None of the Above

25
Q
A

4

26
Q
A

Option #4

27
Q
A

Option 3

28
Q
A

Option 4

29
Q
A

Option 6

30
Q
A

Option 1

31
Q
A

Option 2 (0.1)

32
Q
A

Option 3 (1)

33
Q
A

Figure it out

34
Q
A

?

35
Q
A

Figure it out

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