Drug Absorption Pt. II Flashcards Preview

Fundamentals of Molecular Medicine > Drug Absorption Pt. II > Flashcards

Flashcards in Drug Absorption Pt. II Deck (35):
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Trapping a Weakly Basic 

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Henderson Hasselbach Equation 

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Where is Aspirin, a weak acid, absorbed and why?

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Where is a Chlorodiazepoxide, a weak base, absorbed and why?

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ADME graph at different pH's

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Observations on Drug administration and compartmentalization 

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Examples of Compartments

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pH of Selected Body Fluids

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Quantitative Drug Distribution Problems

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Definition of Acid/Base

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Ibuprofin 

(Weak Acid pKa = 4.4)

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Where will Ibuprofin be efficiently absorbed?

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Drug Partitioning Problems for Weak Acids

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Drug Partioning Problems for Weak Bases

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Special Case of weak acid with very basic PKa

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Weak Base with very acidic PKa

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Adjusting pH to trap drug in urine

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Adjusting Urine pH and effect on Clearance for weak acids

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Adjusting pH and Clearance of Weak Bases

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Real World Example of Drug Clearance

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None of the Above

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#4

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Option #4

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Option 3

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Option 4

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Option 6 

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Option 1

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Option 2 (0.1)

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Option 3 (1) 

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Figure it out

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?

35

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Figure it out

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