Drug Absorption Pt. II Flashcards Preview

Fundamentals of Molecular Medicine > Drug Absorption Pt. II > Flashcards

Flashcards in Drug Absorption Pt. II Deck (35):
1

 

 

 

Trapping a Weakly Basic 

2

 

 

 

Henderson Hasselbach Equation 

3

 

 


Where is Aspirin, a weak acid, absorbed and why?

4

 

 

 

Where is a Chlorodiazepoxide, a weak base, absorbed and why?

5

 

 

 

ADME graph at different pH's

6

 

 

 

Observations on Drug administration and compartmentalization 

7

 

 

 

Examples of Compartments

8

 

 

 

pH of Selected Body Fluids

9

10

 

 

 

Quantitative Drug Distribution Problems

11

 

 

 

Definition of Acid/Base

12

13

14

 

 

 

Ibuprofin 

(Weak Acid pKa = 4.4)

15

 

 

 

Where will Ibuprofin be efficiently absorbed?

16

 

 

 

Drug Partitioning Problems for Weak Acids

17

 

 

 

Drug Partioning Problems for Weak Bases

18

 

 

 

Special Case of weak acid with very basic PKa

or 

Weak Base with very acidic PKa

19

 

 

 

Adjusting pH to trap drug in urine

20

21

 

 

 

Adjusting Urine pH and effect on Clearance for weak acids

22

 

 

 

Adjusting pH and Clearance of Weak Bases

23

 

 

 

Real World Example of Drug Clearance

24

 

 

 

None of the Above

25

 

 

 

#4

26

 

 

 

Option #4

27

 

 

 

Option 3

28

 

 

 

Option 4

29

 

 

 

Option 6 

30

 

 

 

Option 1

31

 

 

 

Option 2 (0.1)

32

 

 

 

Option 3 (1) 

33

 

 

 

Figure it out

34

 

 

 

?

35

 

 

 

Figure it out

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