Compartmentalization of Fluids
Compartments:
Plasma
Capillary Membrane
Interstitial Fluid
Cell Membrane
Intracellular Fluid
E. Freezing point depression
It all depends on the number of particles.
D. Elicits no net water flow from the cells.
Intracellular Concentrations of Ions
Intracellular Concentration of Glucose and Proteins
Total mOsm/L in Plasma vs. Interstitial vs. Intracellular
Fluid and Body Weight
Body water content
Extracellular vs. Intracellular Fluid Content
Blood Volume vs. Plasma Volume
Hematocrit
1 - Hct
Whole Blood Volume
1-Hct — should be called the Plasmacrit.
How do you measure a pool?
Fluid Space Measurement Dye-Dilution Technique
Measurement of Body Fluid Spaces
Plasma Markers
Extracellular Fluid Markers
Total Body Water Markers (Z)
Time to Reach Steady State for Each Compartment
Water Flow Accross Biological Membranes
Size and Charge vs. Membrane
Forces of Water movement
Osmotic Pressure
Osmolar Concentration
Effect of a 150 mM solution of NaCl
Effective Osomotic Pressure
Van’t Hoff Equation
Movement of Water accross Capillary
Colloid Osmotic Pressure
Ultrafiltration
filtration using a medium fine enough to retain colloidal particles, viruses, or large molecules.
Filtration Rate/Starling Equation
Interstitium and Starling Equation
Blood Pressure
Concept of Net Filtration
Movement of Water accross Cell Membrane
D. Plasma Space, Interstitial same and intracellular space would all loose fluid proportionally.
When we sweat we lose more water than we do salt. So ECF becomes concentrated and water will flow from inside to outside cell. But all 3 would loose water proportionally.
B. Most of the water would come from the extracellular space (plasma + interstitial) Why is this different? Because when we bleed we lost an isotonic fluid so we didn’t create an osmotic imbalance. Therefore there’s no osmotic force that draws out water from our intracellular space.
Isotonic vs. Isosmotic
Solutions and Isosmotic vs. Isotonic
D. Expansion of both the extracellular space and the intracellular space
Glucose get’s taken into the cells very quickly and you end up with a infusion of water with essentially no solute. This is very bad.
Blood cells will undergo hemolysis — RBC’s would explode because they would take in the water.