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Fundamentals of Molecular Medicine > Radiation Therapy > Flashcards

Flashcards in Radiation Therapy Deck (26)
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1
Q

Discovery of X-rays

A

Roentgen 1895

2
Q

Discovery of Radioactivity

A

Becquerel1896

3
Q

Definition of Radiation

A

Radiation=Energy

4
Q

Diagnostic vs. Therapeutic Radiation

A

Therapeutic radiation is of higher energy

5
Q

Radiation Machines

A

Superficial machines, orthovoltage, Cobalt, Linear Accelerators

6
Q

Radiation Sources

A

Cobalt, Radium, Iridium, Iodine, Gold,Cesium,Palladium

7
Q

Mechanism of Radiation Cytotoxicity

A

DNA injury

8
Q

CANCERS COMMONLY TREATED EFFECTIVELY WITH RADIATION THERAPY ALONE

A

Squamous cell carcinomas of head and neck Squamous and basal cell carcinomas of skin Cervical cancers

Vaginal cancers

Prostate cancers Hodgkin’s Disease NonHodgkin’s lymphoma

9
Q

CANCERS COMMONLY TREATED EFFECTIVELY WITH THE COMBINATION OF SURGERY AND RADIATION THERAPY

A

Head and neck cancers Brain tumors

Uterine cancer

Colorectal cancer Breast cancer

Soft tissue sarcomas

10
Q

CANCERS COMMONLY TREATED WITH THE COMBINATION OF CHEMOTHERAPY AND RADIATION THERAPY

A

NonHodgkin’s lymphoma Hodgkin’s Disease

Anal cancer

Esophagus cancer

Head and neck cancers

Inflammatory breast cancer

11
Q

Very Sensitive Tumor to Radiation

A

Germ cell tumors

Lymphomas

12
Q

Moderately Sensitive

A

Adenocarcinomas

Squamous cell carcinomas

13
Q

Less Sensitive to Radiation

A

Osteogenic sarcomas

Renal cell carcinomas

14
Q

RADIATION DOSES REQUIRED FOR 90% liKEliHOOD OF CONTROL OF SQUAMOUS AND ADENOCARCINOMAS

A

Microscopic disease: 1em of disease :

2 em of disease:

5000 cGy in 25 treatments

6000 cGy in 30 treatments

7000 cGy in 35 treatments

15
Q

INDICATIONS FOR RADIOTHERAPY

A

Cancers which can’t be resected or resection would cause unacceptable cosmetic or functional deficit

16
Q

TECHNIQUES IN RADIOTHERAPY

A

Physical Aspects (Exclude as much normal tissue as possible)

Beam Orientations

Beam Shape

Radiation Energy

Source Distance

Number of Fields

17
Q

Fractionation

A

FractionationDividing total radiation dose into number of small treatments

18
Q

BRACHYTHERAPY INDICATIONS

A

Definitive Treatment

Boost Treatment

Recurrent Disease

Pediatrics

19
Q

Acute Toxicity

A

Dependent upon total dose, fraction size, interval between fractions

20
Q

Late Toxicity

A

Dependent upon total dose and fraction size

21
Q

FUTURE DIRECTIONS IN RADIOTHERAPY

A

Increasingly localized treatment

Altered fractionation

Concurrent systemic agents

Assays for tumor response

Assays for normal tissue response

Tailoring of treatment based on genetic profile

22
Q

Rationale for Non-Surgical Treatment

A
23
Q

Rationale for Fractionation

A
24
Q

Senstitivity of Tumors to Radiation

A
25
Q

Indirect Action vs. Direct Action of DNA Damage

A
26
Q

Diagnostic vs. Therapeutic

RAD

A

Diagnostic vs. Therapeutic Radiation— Low energy photons for diagnostic — High Energy radiation for therapeutic.

RAD — Radiation absorbed Dose

Centigrade and RAD used interchangeably.

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