Hemoglobin Structure and Function Flashcards Preview

Fundamentals of Molecular Medicine > Hemoglobin Structure and Function > Flashcards

Flashcards in Hemoglobin Structure and Function Deck (45):
1

 

 

 

Hemoglobinopathies

2

 

 

 

Hemoglobin vs. Myoglobin

3

 

 

 

3 Demensional Folding of Myoglobin

4

 

 

 

What is a Heme Group?

5

 

 

 

Heme oxidation States and binding

6

 

 

 

Oxygen binding to heme

7

 

 

 

Carbon Monoxide Binding to Heme without Distal Histidine

8

 

 

 

Carbon Monoxide Binding to Heme with Distal Histidine

9

 

 

 

Comparision of CO and O2 Binding to Myoglobin

10

 

 

 

Tertiary/Quaternary Structure of Hemoglobin

11

 

 

 

Features of Quaternary Structure

12

 

 

 

Cooperativity as a series of Equilibria

13

 

 

 

Comparision of Oxygen Binding Curves of Rstate and Tstate

14

 

 

 

What are the major regulators of Cooperative Oxygen Binding 

15

 

 

 

Hemoglobin and Allosteric Sturcutre Function Relationship

16

 

 

 

Key Residues of Beta Chain Involved in the Allosteric Mechanism of Cooperativity 

17

 

 

 

Interactions of the Deoxy T form

18

 

 

 

Hemoglobin Key Beta Chain Residues

19

 

 

 

The Globin Pocket

20

 

 

 

Hemoglobin Conformational Changes

21

 

 

 

Space Filling Model of Hb Oxygenation 

22

 

 

 

Comparision of Oxygen Binding Curves for Myoglobin and Hemoglobin

23

 

 

 

Oxygen Binding of Fetal Hemoglobin

24

 

 

 

Relevant Features of 2,3 BPG

25

 

 

 

BPG Binding to Hemoglobin

26

 

 

 

Rotation of the Alpha Beta Dimer

27

 

 

 

Allosteric Effects of BPG

28

 

 

 

How does cooperativity occur?

29

 

 

 

Iron interaction with Oxygen in tense and relaxed states

30

 

 

 

Mechanism of the Tense to Relaxed Form

31

 

 

 

Heme role in modulating protein structure

32

 

 

 

Molecular Basis for Hemoglobin Cooperativity

33

 

 

 

A Mechanism for Oxygen Binding

34

 

 

 

A mechanism for Oxygen Binding Cont.

35

 

 

 

The Bohr Effect

36

 

 

 

Effect of CO2 on O2 affinity of Hemoglobin

37

 

 

 

Effect of Allosteric Effectors on the Oxygen Affinity for Hemoglobin

38

 

 

 

Role of His 146 in Bohr Effect

39

 

 

 

CO2 transported in the blood from tissue to lungs

40

 

 

 

Influence of Bohr Effect on Carbonic Acid and CO2 equlibrium 

41

 

 

 

Summary of Mechanism of Coorperativity

42

 

 

 

HbS Sickle Cell Disease

43

 

 

 

Amino Acid Alteration in Sickle Cell

44

 

 

 

Aggregation and Polymerization of HbS

45

 

 

 

Sickle Cell Disease Biochemical Defect

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