Hemoglobin Structure and Function

Question 1

Hemoglobinopathies

Answer 1

Question 2

Hemoglobin vs. Myoglobin

Answer 2

Question 3

3 Demensional Folding of Myoglobin

Answer 3

Question 4

What is a Heme Group?

Answer 4

Question 5

Heme oxidation States and binding

Answer 5

Question 6

Oxygen binding to heme

Answer 6

Question 7

Carbon Monoxide Binding to Heme without Distal Histidine

Answer 7

Question 8

Carbon Monoxide Binding to Heme with Distal Histidine

Answer 8

Question 9

Comparision of CO and O2 Binding to Myoglobin

Answer 9

Question 10

Tertiary/Quaternary Structure of Hemoglobin

Answer 10

Question 11

Features of Quaternary Structure

Answer 11

Question 12

Cooperativity as a series of Equilibria

Answer 12

Question 13

Comparision of Oxygen Binding Curves of Rstate and Tstate

Answer 13

Question 14

What are the major regulators of Cooperative Oxygen Binding

Answer 14

Question 15

Hemoglobin and Allosteric Sturcutre Function Relationship

Answer 15

Question 16

Key Residues of Beta Chain Involved in the Allosteric Mechanism of Cooperativity

Answer 16

Question 17

Interactions of the Deoxy T form

Answer 17

Question 18

Hemoglobin Key Beta Chain Residues

Answer 18

Question 19

The Globin Pocket

Answer 19

Question 20

Hemoglobin Conformational Changes

Answer 20

Question 21

Space Filling Model of Hb Oxygenation

Answer 21

Question 22

Comparision of Oxygen Binding Curves for Myoglobin and Hemoglobin

Answer 22

Question 23

Oxygen Binding of Fetal Hemoglobin

Answer 23

Question 24

Relevant Features of 2,3 BPG

Answer 24

Question 25

BPG Binding to Hemoglobin

Answer 25

Question 26

Rotation of the Alpha Beta Dimer

Answer 26

Question 27

Allosteric Effects of BPG

Answer 27

Question 28

How does cooperativity occur?

Answer 28

Question 29

Iron interaction with Oxygen in tense and relaxed states

Answer 29

Question 30

Mechanism of the Tense to Relaxed Form

Question 31

Heme role in modulating protein structure

Answer 31

Question 32

Molecular Basis for Hemoglobin Cooperativity

Answer 32

Question 33

A Mechanism for Oxygen Binding

Answer 33

Question 34

A mechanism for Oxygen Binding Cont.

Answer 34

Question 35

The Bohr Effect

Answer 35

Question 36

Effect of CO2 on O2 affinity of Hemoglobin

Answer 36

Question 37

Effect of Allosteric Effectors on the Oxygen Affinity for Hemoglobin

Answer 37

Question 38

Role of His 146 in Bohr Effect

Answer 38

Question 39

CO2 transported in the blood from tissue to lungs

Answer 39

Question 40

Influence of Bohr Effect on Carbonic Acid and CO2 equlibrium

Answer 40

Question 41

Summary of Mechanism of Coorperativity

Answer 41

Question 42

HbS Sickle Cell Disease

Answer 42

Question 43

Amino Acid Alteration in Sickle Cell

Answer 43

Question 44

Aggregation and Polymerization of HbS

Answer 44

Question 45

Sickle Cell Disease Biochemical Defect

Answer 45