Hemoglobin Structure and Function Flashcards Preview

Fundamentals of Molecular Medicine > Hemoglobin Structure and Function > Flashcards

Flashcards in Hemoglobin Structure and Function Deck (45):
1

 

 

 

Hemoglobinopathies

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2

 

 

 

Hemoglobin vs. Myoglobin

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3

 

 

 

3 Demensional Folding of Myoglobin

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4

 

 

 

What is a Heme Group?

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5

 

 

 

Heme oxidation States and binding

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6

 

 

 

Oxygen binding to heme

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7

 

 

 

Carbon Monoxide Binding to Heme without Distal Histidine

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8

 

 

 

Carbon Monoxide Binding to Heme with Distal Histidine

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9

 

 

 

Comparision of CO and O2 Binding to Myoglobin

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10

 

 

 

Tertiary/Quaternary Structure of Hemoglobin

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11

 

 

 

Features of Quaternary Structure

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12

 

 

 

Cooperativity as a series of Equilibria

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13

 

 

 

Comparision of Oxygen Binding Curves of Rstate and Tstate

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14

 

 

 

What are the major regulators of Cooperative Oxygen Binding 

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15

 

 

 

Hemoglobin and Allosteric Sturcutre Function Relationship

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16

 

 

 

Key Residues of Beta Chain Involved in the Allosteric Mechanism of Cooperativity 

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17

 

 

 

Interactions of the Deoxy T form

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18

 

 

 

Hemoglobin Key Beta Chain Residues

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19

 

 

 

The Globin Pocket

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20

 

 

 

Hemoglobin Conformational Changes

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21

 

 

 

Space Filling Model of Hb Oxygenation 

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22

 

 

 

Comparision of Oxygen Binding Curves for Myoglobin and Hemoglobin

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23

 

 

 

Oxygen Binding of Fetal Hemoglobin

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24

 

 

 

Relevant Features of 2,3 BPG

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25

 

 

 

BPG Binding to Hemoglobin

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26

 

 

 

Rotation of the Alpha Beta Dimer

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27

 

 

 

Allosteric Effects of BPG

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28

 

 

 

How does cooperativity occur?

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29

 

 

 

Iron interaction with Oxygen in tense and relaxed states

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30

 

 

 

Mechanism of the Tense to Relaxed Form

31

 

 

 

Heme role in modulating protein structure

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32

 

 

 

Molecular Basis for Hemoglobin Cooperativity

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33

 

 

 

A Mechanism for Oxygen Binding

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34

 

 

 

A mechanism for Oxygen Binding Cont.

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35

 

 

 

The Bohr Effect

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36

 

 

 

Effect of CO2 on O2 affinity of Hemoglobin

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37

 

 

 

Effect of Allosteric Effectors on the Oxygen Affinity for Hemoglobin

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38

 

 

 

Role of His 146 in Bohr Effect

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39

 

 

 

CO2 transported in the blood from tissue to lungs

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40

 

 

 

Influence of Bohr Effect on Carbonic Acid and CO2 equlibrium 

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41

 

 

 

Summary of Mechanism of Coorperativity

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42

 

 

 

HbS Sickle Cell Disease

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43

 

 

 

Amino Acid Alteration in Sickle Cell

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44

 

 

 

Aggregation and Polymerization of HbS

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45

 

 

 

Sickle Cell Disease Biochemical Defect

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