Pharmacodynamics Part I Flashcards Preview

Fundamentals of Molecular Medicine > Pharmacodynamics Part I > Flashcards

Flashcards in Pharmacodynamics Part I Deck (54):
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General Features of Receptors

2

 

 

 

Agonist Def. 

3

 

 

 

Antagonist Definition

4

 

 

 

2 Critical Features of Receptors

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For almost all drugs the dose response curve is....

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Dose Response Curve for Almost All Drugs

7

 

 

 

How does a dose response curve look when it's in a semilog plot

8

 

 

 

Plotting Equation for Linear or Semilog 

9

 

 

 

Def. of Potency 

10

 

 

 

Def. of Efficacy 

11

 

 

 

Relationship between Potency and Efficacy 

12

 

 

 

Alt Eqn for semilog or linear plot

13

 

 

 

Values of Range of Binding/Response

14

 

 

 

100 Fold

15

16

 

 

 

Dose Response Curve for 4 different Analgasic Drugs

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Explain the Potency and Efficacy of these 4 Drugs

18

 

 

 

Explain this Graph

 

 

 

 

19

20

 

 

 

Cool Quote by Paracelsus

21

 

 

 

Explain the Concept of Quantal Response

22

 

 

 

Def and Eq. of Therapuetic Index

23

 

 

 

Margin of Safety 

24

 

 

 

Doses that cause side effects...

25

 

 

 

Plot of Therapuetic Index vs. MoS

26

 

 

 

Aspirin: Therapuetic Effect, Side Effect, Lethality

27

28

 

 

 

Effect vs. Agonist

29

 

 

 

Binding Vs. Agonist

30

31

 

 

 

Spare Receptors

32

 

 

 

Advantages of Spare Receptors

33

 

 

 

Spare Receptors and Proof of Less Desensitizaiton

34

 

 

 

Spare Receptors and Greater Sensitivity

35

 

 

 

Spare Receptors, Increased Sensitivity, and Drug Concentration 

36

 

 

 

Drug Binding and Dissociation Constant

37

 

 

 

Lower Kd and Range

38

 

 

 

Variability of on rates vs. off rates

39

40

 

 

 

Kd and Implications of choosing a drug

41

42

 

 

 

Efficacy and Potency for Partial and 

43

 

 

 

Efficacy of Partial Agonist vs. Full Agonist

44

 

 

 

Proper dose of Partial agonist and baseline

45

 

 

 

Lowering the Full Agonist Response

46

 

 

 

Partial agonist intervention compared to full agonists or antagonists

47

 

 

 

Buprenorphine

48

 

 

 

Buprenorphine Response Curve

49

 

 

 

Agonists, antagonists, and efficacy

50

 

 

 

Can we account for full agonists, partial agonists, and antagonists with one simple model?

51

 

 

 

R to R model

52

 

 

 

R to R model of Action for agonists, partial agonists, antagonists, and reverse agonists

53

 

 

 

Inverse Agonist

54

 

 

 

Summary of Agonists, Partial Agonists, Antagonists, and Inverse Agonists

Decks in Fundamentals of Molecular Medicine Class (77):