Pharmacodynamics Part I Flashcards Preview

Fundamentals of Molecular Medicine > Pharmacodynamics Part I > Flashcards

Flashcards in Pharmacodynamics Part I Deck (54):
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General Features of Receptors

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Agonist Def. 

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Antagonist Definition

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2 Critical Features of Receptors

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For almost all drugs the dose response curve is....

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Dose Response Curve for Almost All Drugs

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How does a dose response curve look when it's in a semilog plot

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Plotting Equation for Linear or Semilog 

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Def. of Potency 

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Def. of Efficacy 

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Relationship between Potency and Efficacy 

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Alt Eqn for semilog or linear plot

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Values of Range of Binding/Response

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100 Fold

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Dose Response Curve for 4 different Analgasic Drugs

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Explain the Potency and Efficacy of these 4 Drugs

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Explain this Graph

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Cool Quote by Paracelsus

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Explain the Concept of Quantal Response

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Def and Eq. of Therapuetic Index

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Margin of Safety 

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Doses that cause side effects...

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Plot of Therapuetic Index vs. MoS

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Aspirin: Therapuetic Effect, Side Effect, Lethality

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Effect vs. Agonist

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Binding Vs. Agonist

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Spare Receptors

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Advantages of Spare Receptors

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Spare Receptors and Proof of Less Desensitizaiton

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Spare Receptors and Greater Sensitivity

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Spare Receptors, Increased Sensitivity, and Drug Concentration 

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Drug Binding and Dissociation Constant

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Lower Kd and Range

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Variability of on rates vs. off rates

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Kd and Implications of choosing a drug

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Efficacy and Potency for Partial and 

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Efficacy of Partial Agonist vs. Full Agonist

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Proper dose of Partial agonist and baseline

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Lowering the Full Agonist Response

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Partial agonist intervention compared to full agonists or antagonists

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Buprenorphine

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Buprenorphine Response Curve

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Agonists, antagonists, and efficacy

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Can we account for full agonists, partial agonists, and antagonists with one simple model?

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R to R model

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R to R model of Action for agonists, partial agonists, antagonists, and reverse agonists

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Inverse Agonist

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Summary of Agonists, Partial Agonists, Antagonists, and Inverse Agonists

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Decks in Fundamentals of Molecular Medicine Class (77):