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Fundamentals of Molecular Medicine > Review > Flashcards

Flashcards in Review Deck (113):
1

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Carbon use in THF

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Synthesis of PRPP 

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Committed Step of Purine Synthesis

Name of Enzyme

How is it Regulated

Reactants/Substrates/Products

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IMP to AMP

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6

 

 

 

Biosynthesis of GMP

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7

 

 

 

GMP to GDP 

and AMP to ADP 

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8

 

 

 

Regulation of DeNovo Purine Synthesis

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What leads to overproduction of Purines

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10

 

 

 

Purine Salvage

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11

 

 

 

Purine Nucleotide Cycle

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12

 

 

 

Adensoine Degredation

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13

 

 

 

Guanosine Degredation 

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14

 

 

 

Uricase 

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15

 

 

 

Xanthine Oxidase

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16

 

 

 

Purine Metabolism Defects

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17

 

 

 

Carbon Sources for Pyrimidine

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18

 

 

 

DeNovo Pyrimidine Synthesis 

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19

 

 

 

Pyrimidine Synthesis Continued

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20

 

 

 

CTP Synthetase

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21

 

 

 

Reduction of Ribonucleotides

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22

 

 

 

Ribonucleotide Reductase Regulation 

 

 

 

2 Allosteric Sites one substrate Specificity and the other Overally activity

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23

 

 

 

dTMP Synthesis

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24

 

 

Adenosine Deaminase Deficiency Revisited

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25

 

 

 

Pyrimidine Base Salvage

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26

 

 

 

Hereditary Orotic Aciduria

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27

 

 

 

Importance of Folate

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28

 

 

 

Folate Analogs

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29

 

 

 

How does folate kill rapidly dividing cells

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30

 

 

 

One Carbon Metabolism Revisited

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31

 

 

 

Primary vs. Secondary Immune Response

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32

 

 

 

Opsonization 

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33

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34

 

 

 

Fetal Immunoglobulins

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35

 

 

 

IgM vs. IgG Affinity Maturation

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36

 

 

 

Two Types of Opsonization 

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37

 

 

 

4 Effector Functions of Neutralization 

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38

 

 

 

IgE 

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39

 

 

 

Affinity vs. Avidity

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40

 

 

 

Ag-Ab Immune Complex

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Antibody Titer

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42

 

 

 

Elisa 

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Western Blot

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44

 

 

 

Agglutination 

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45

 

 

 

Hemolytic Disease of the Newborn 

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46

 

 

 

Direct vs Indirect Coombs Test

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47

 

 

 

Rhogam 

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48

 

 

 

Sporadic, Familial, Hereditary

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49

 

 

 

CML vs. ALL Neoplasia

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50

 

 

 

PARP Inhibitors

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51

 

 

 

Beta Catenin and APC

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52

 

 

 

NF1 Mutation 

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53

 

 

 

Genetics of Basal Cel Carcinoma

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54

 

 

 

Nevoid Basal Cell Carcinoma

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55

 

 

 

Vismodegiv

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56

 

 

 

Familial Melanoma

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57

 

 

 

Caclium Absorption 

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58

 

 

 

Regulation of Plasma Calcium 

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59

 

 

 

Osteoporosis and Hypercalcemia 

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60

 

 

 

Iron Absorption 

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61

 

 

 

Reduction and Enhancement of Iron Absorption 

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62

 

 

 

Iron Deficiency 

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63

 

 

 

Hemochromatosis 

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64

 

 

 

Roles and Dietary Sources of Magnesium 

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65

 

 

 

Magnesium Deficiency and Toxicity 

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66

 

 

 

Light Chain and Heavy Chain Rearrangement

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67

 

 

 

How many times do Heavy Chains Undergo Somatic Recombination compared to Light Chains

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68

 

 

 

RAG 

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69

 

 

 

Junctional Diversity 

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70

 

 

 

T-Cell Repitoire vs. Ig Repitoire

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71

 

 

 

Allelic Exclusion 

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72

 

 

 

Somatic Hypermutation 

(Not Somatic Recombination)

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73

 

 


AID

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74

 

 

 

T-Cell Features

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Somatic Recombination vs. Somatic Hypermutation in Ig vs. TCR

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76

 

 

 

Life Cycle of Listeria Monocytogenes

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MHC Class II Processing

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78

 

 

 

MHCI Processing 

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79

 

 

 

Viral Inhibitors of MHC Class I

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80

 

 

 

Immune Adherence 

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81

 

 

 

Anaphyatoxins

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82

 

 

 

Roles of Complement 

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83

 

 

 

Complement Pathway 

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84

 

 

 

Classical Pathway 

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85

 

 

 

Classical vs. Alternate vs. Lectin Pathway 

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Alternate Pathway 

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87

 

 

 

DAF and C1 Esterase Inhibitor

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88

 

 

 

Enrichement vs. Fortification 

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89

 

 

 

Role of Beta Carotine 

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90

 

 

 

Vitamin A Deficiency 

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91

 

 

 

Water Soluble Vitamins

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92

 

 

 

Fat Soluble Vitamins

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93

 

 

 

Sensitivity vs. Specificity 

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94

 

 

 

Positive/Negative Predictor Value

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95

 

 

 

Exome Sequencing 

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96

 

 

 

Expression of MHC I vs. MHC II

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97

 

 

 

HLA MHC II region 

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98

 

 

 

MHC binding Domain vs. Ig Binding Domain 

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99

 

 

 

MHC Restriction 

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100

 

 

 

# of MHC I vs. MHCII expressed

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101

 

 

 

MHC Pockets

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102

 

 

 

Codominant Expression 

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103

 

 

 

Lysosome Formation 

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104

 

 

 

Ubiquitination 

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105

 

 

 

Ring vs. Hect

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106

 

 

 

Proteosome Structure

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107

 

 

 

Regulation of Proteosome

108

 

 

 

Macronutrient Distribution 

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109

 

 

 

PLasma LDL Levels

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110

 

 

 

Streptococcus Thermophilus

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111

 

 

S. Pyogenes

112

 

 

 

Cas9 Specificity 

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113

 

 

 

Non-Homologous End Joining

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Decks in Fundamentals of Molecular Medicine Class (77):