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Fundamentals of Molecular Medicine > Review > Flashcards

Flashcards in Review Deck (113):
1

2

 

 

Carbon use in THF

3

 

 

 

Synthesis of PRPP 

4

 

Committed Step of Purine Synthesis

Name of Enzyme

How is it Regulated

Reactants/Substrates/Products

5

 

 

 

IMP to AMP

6

 

 

 

Biosynthesis of GMP

7

 

 

 

GMP to GDP 

and AMP to ADP 

8

 

 

 

Regulation of DeNovo Purine Synthesis

9

 

 

 

What leads to overproduction of Purines

10

 

 

 

Purine Salvage

11

 

 

 

Purine Nucleotide Cycle

12

 

 

 

Adensoine Degredation

13

 

 

 

Guanosine Degredation 

14

 

 

 

Uricase 

15

 

 

 

Xanthine Oxidase

16

 

 

 

Purine Metabolism Defects

17

 

 

 

Carbon Sources for Pyrimidine

18

 

 

 

DeNovo Pyrimidine Synthesis 

19

 

 

 

Pyrimidine Synthesis Continued

20

 

 

 

CTP Synthetase

21

 

 

 

Reduction of Ribonucleotides

22

 

 

 

Ribonucleotide Reductase Regulation 

 

 

 

2 Allosteric Sites one substrate Specificity and the other Overally activity

23

 

 

 

dTMP Synthesis

24

 

 

Adenosine Deaminase Deficiency Revisited

25

 

 

 

Pyrimidine Base Salvage

26

 

 

 

Hereditary Orotic Aciduria

27

 

 

 

Importance of Folate

28

 

 

 

Folate Analogs

29

 

 

 

How does folate kill rapidly dividing cells

30

 

 

 

One Carbon Metabolism Revisited

31

 

 

 

Primary vs. Secondary Immune Response

32

 

 

 

Opsonization 

33

34

 

 

 

Fetal Immunoglobulins

35

 

 

 

IgM vs. IgG Affinity Maturation

36

 

 

 

Two Types of Opsonization 

37

 

 

 

4 Effector Functions of Neutralization 

38

 

 

 

IgE 

39

 

 

 

Affinity vs. Avidity

40

 

 

 

Ag-Ab Immune Complex

41

 

 

 

Antibody Titer

42

 

 

 

Elisa 

43

 

 

Western Blot

44

 

 

 

Agglutination 

45

 

 

 

Hemolytic Disease of the Newborn 

46

 

 

 

Direct vs Indirect Coombs Test

47

 

 

 

Rhogam 

48

 

 

 

Sporadic, Familial, Hereditary

49

 

 

 

CML vs. ALL Neoplasia

50

 

 

 

PARP Inhibitors

51

 

 

 

Beta Catenin and APC

52

 

 

 

NF1 Mutation 

53

 

 

 

Genetics of Basal Cel Carcinoma

54

 

 

 

Nevoid Basal Cell Carcinoma

55

 

 

 

Vismodegiv

56

 

 

 

Familial Melanoma

57

 

 

 

Caclium Absorption 

58

 

 

 

Regulation of Plasma Calcium 

59

 

 

 

Osteoporosis and Hypercalcemia 

60

 

 

 

Iron Absorption 

61

 

 

 

Reduction and Enhancement of Iron Absorption 

62

 

 

 

Iron Deficiency 

63

 

 

 

Hemochromatosis 

64

 

 

 

Roles and Dietary Sources of Magnesium 

65

 

 

 

Magnesium Deficiency and Toxicity 

66

 

 

 

Light Chain and Heavy Chain Rearrangement

67

 

 

 

How many times do Heavy Chains Undergo Somatic Recombination compared to Light Chains

68

 

 

 

RAG 

69

 

 

 

Junctional Diversity 

70

 

 

 

T-Cell Repitoire vs. Ig Repitoire

71

 

 

 

Allelic Exclusion 

72

 

 

 

Somatic Hypermutation 

(Not Somatic Recombination)

73

 

 


AID

74

 

 

 

T-Cell Features

75

 

 

Somatic Recombination vs. Somatic Hypermutation in Ig vs. TCR

76

 

 

 

Life Cycle of Listeria Monocytogenes

77

 

 

 

MHC Class II Processing

78

 

 

 

MHCI Processing 

79

 

 

 

Viral Inhibitors of MHC Class I

80

 

 

 

Immune Adherence 

81

 

 

 

Anaphyatoxins

82

 

 

 

Roles of Complement 

83

 

 

 

Complement Pathway 

84

 

 

 

Classical Pathway 

85

 

 

 

Classical vs. Alternate vs. Lectin Pathway 

86

 

 

 

Alternate Pathway 

87

 

 

 

DAF and C1 Esterase Inhibitor

88

 

 

 

Enrichement vs. Fortification 

89

 

 

 

Role of Beta Carotine 

90

 

 

 

Vitamin A Deficiency 

91

 

 

 

Water Soluble Vitamins

92

 

 

 

Fat Soluble Vitamins

93

 

 

 

Sensitivity vs. Specificity 

94

 

 

 

Positive/Negative Predictor Value

95

 

 

 

Exome Sequencing 

96

 

 

 

Expression of MHC I vs. MHC II

97

 

 

 

HLA MHC II region 

98

 

 

 

MHC binding Domain vs. Ig Binding Domain 

99

 

 

 

MHC Restriction 

100

 

 

 

# of MHC I vs. MHCII expressed

101

 

 

 

MHC Pockets

102

 

 

 

Codominant Expression 

103

 

 

 

Lysosome Formation 

104

 

 

 

Ubiquitination 

105

 

 

 

Ring vs. Hect

106

 

 

 

Proteosome Structure

107

 

 

 

Regulation of Proteosome

108

 

 

 

Macronutrient Distribution 

109

 

 

 

PLasma LDL Levels

110

 

 

 

Streptococcus Thermophilus

111

 

 

S. Pyogenes

112

 

 

 

Cas9 Specificity 

113

 

 

 

Non-Homologous End Joining

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