Objectives
Overview of Signal Transduction
Cellular Communication and the Cell Cycle
Processes that Require Cell Signaling
Cellular Communication and Energy Metabolism
Cell Commuinication and Extracellular Environment
Cellular Communication and Immune Defense
Types of Chemical Messengers
Neurotransmitters
Hormones
Cytokines
Growth Factors
Eicosanoids
Retinoids
Signal Classification by Distance
Endocrine
Paracrine
Autocrine
Autocrine can be an abnormal process that cancer takes advantage of.
General Characteristics of Receptors
Two Major Classes of Receptors
Inttracellular Receptors
Plasma Membrane Receptors
Ion Channel Receptors
Similar features of Tyrosine Kinase, JAK-STAT, Serine Threonine Kinase Receptors
Tyrosine Kinase Receptors
JAK-STAT Receptors
Serine-Threonine Kinase Receptors
Tyrosine Kinase Features
Epidermal Growth Factor
Tyrosine Kinase Receptor
Insulin Signaling
Insulin Signaling and Glucose Uptake
AKT and WTF?
Tyrosine Kinase Receptor
Tyrosine Kinase — is more involved in cancer because it effects the cell cycle
Features of Serine-Threonine Kinases
TGF-Beta Receptors
JAK STAT Receptors
Heptahelical Receptors
GPCR’s
GPCR’s and CyclicAMP
GPCR’s and IP3
Ubiquitin
Phosphatase
GTPase
G-Protein require the help of GAP proteins.
Responding to a Receptor Requires…
Ras and Ret
Ras and Colon Cancer
Colon Cancer Treatment Implications