Nucleic Acids Pt. II Flashcards by Omar Saqr

Q

Adenosine Degredation

A

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Q

Guanosine Degredation

A

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Q

Treatments for Gout

A

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Q

Uricase

A

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Q

Xanthine Oxidase

A

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Q

Gout: Hyperuricemia

A

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Q

Lesch Nyhan Syndrome

A

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Q

Adenosine Deaminase Deficiency

A

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Q

PNP Deficiency

A

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Q

Carbon Sources for Pyrimidine

A

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Q

Pyrimidine Biosynthesis

A

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Q

Which one of the following is a precursor for both purine and pyrimidine biosynthesis?

PRPP

Aspartate

Ammonia

Glycine

Carbon Dioxide

A

Which one of the following is a precursor for both purine and pyrimidine biosynthesis?

PRPP

Aspartate — Donates Nitrogen on carbon 1

Ammonia

Glycine

Carbon Dioxide

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Q

Dihydroorotate Synthesis

A

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Q

UMP Synthesis

A

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Q

Synthesis of UTP and CTP

A

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Q

The UTP to CTP reaction is similar to:

Imp to AMP

IMP to CMP

IMP to XMP

XMP to GMP

XMP to UMP

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A

The UTP to CTP reaction is similar to:

Imp to AMP

IMP to CMP

IMP to XMP

XMP to GMP — Requires Glutamine as a Nitrogen Source

XMP to UMP

Q

Biosynthesis of Deoxyribonucleotides

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A

Q

Regulation of Ribonucleotide Reductase

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A

Q

Preferred Substrate

Effector at Overall Activity Site

Effector at Substrate Specificity Site

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A

Q

Ribonucleotide Reductase Rationale for Regulation

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A

Q

Synthesis of dTMP

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A

Q

Thymidylate Synthase

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A

Q

Adensoine Deaminase Deficiency

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A

Q

Pyrimidine Base Salvage

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A

Pyrimidine Catabolism

Hereditary Orotic Aciduria

One Carbon Metabolism

Tetrahydrofolate

Why are folates important?

Folate Analogs

How do Folate Analogs kill Dividing Cells?

Azaserine

5-Flourouracil

Methotrexate

People with G6PDH deficiency shouldn’t take Sulfonamide. Which one of the pathways would not be inhibited by Azaserine? Inosine Biosynthesis Orotic Acid Biosynthesis GMP Synthesis from IMP AMP Synthesis from IMP CTP Synthesis from UTP

People with G6PDH deficiency shouldn’t take Sulfonamide. Which one of the pathways would not be inhibited by Azaserine? Inosine Biosynthesis Orotic Acid Biosynthesis GMP Synthesis from IMP **AMP Synthesis from IMP — Requires aspartate instead, every other pathway requires glutamine.** CTP Synthesis from UTP

Case Study

Adenosine Deaminase Deficiency — Deoxyadensine accumulates and causes problems.