Nucleic Acids Pt. II Flashcards Preview

Fundamentals of Molecular Medicine > Nucleic Acids Pt. II > Flashcards

Flashcards in Nucleic Acids Pt. II Deck (36):
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Adenosine Degredation

2

 

 

 

Guanosine Degredation 

3

 

 

 

Treatments for Gout

4

 

 

 

Uricase

5

 

 

 

Xanthine Oxidase

6

 

 

 

Gout: Hyperuricemia 

7

 

 

 

Lesch Nyhan Syndrome

8

 

 

 

Adenosine Deaminase Deficiency 

9

 

 

 

PNP Deficiency 

10

 

 

 

Carbon Sources for Pyrimidine

11

 

 

 

Pyrimidine Biosynthesis

12

Which one of the following is a precursor for both purine and pyrimidine biosynthesis?

PRPP

Aspartate

Ammonia

Glycine

Carbon Dioxide 

Which one of the following is a precursor for both purine and pyrimidine biosynthesis?

PRPP

Aspartate — Donates Nitrogen on carbon 1

Ammonia

Glycine

Carbon Dioxide 

 

13

 

 

 

Dihydroorotate Synthesis 

14

 

 

 

UMP Synthesis 

15

 

 

 

Synthesis of UTP and CTP

16

The UTP to CTP reaction is similar to:

Imp to AMP

IMP to CMP

IMP to XMP

XMP to GMP 

XMP to UMP

The UTP to CTP reaction is similar to:

Imp to AMP

IMP to CMP

IMP to XMP

XMP to GMP — Requires Glutamine as a Nitrogen Source

XMP to UMP

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Biosynthesis of Deoxyribonucleotides

18

 

 

 

Regulation of Ribonucleotide Reductase

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Preferred Substrate

Effector at Overall Activity Site

Effector at Substrate Specificity Site

20

 

 

 

Ribonucleotide Reductase Rationale for Regulation

21

 

 

 

Synthesis of dTMP

22

 

 

 

Thymidylate Synthase

23

 

 

 

Adensoine Deaminase Deficiency 

24

 

 

 

Pyrimidine Base Salvage

25

 

 

 

Pyrimidine Catabolism 

26

 

 

 

Hereditary Orotic Aciduria

27

 

 

 

One Carbon Metabolism 

28

 

 

 

Tetrahydrofolate

29

 

 

 

Why are folates important?

30

 

 

 

Folate Analogs

31

 

 

 

How do Folate Analogs kill Dividing Cells?

32

 

 

 

Azaserine

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5-Flourouracil

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Methotrexate

35

People with G6PDH deficiency shouldn’t take Sulfonamide. 

Which one of the pathways would not be inhibited by Azaserine?

Inosine Biosynthesis 

Orotic Acid Biosynthesis

GMP Synthesis from IMP

AMP Synthesis from IMP 

CTP Synthesis from UTP

People with G6PDH deficiency shouldn’t take Sulfonamide. 

Which one of the pathways would not be inhibited by Azaserine?

Inosine Biosynthesis 

Orotic Acid Biosynthesis

GMP Synthesis from IMP

AMP Synthesis from IMP — Requires aspartate instead, every other pathway requires glutamine. 

CTP Synthesis from UTP

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Case Study 

 

 

 

Adenosine Deaminase Deficiency — Deoxyadensine accumulates and causes problems. 

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