Nucleic Acids Pt. II Flashcards Preview

Fundamentals of Molecular Medicine > Nucleic Acids Pt. II > Flashcards

Flashcards in Nucleic Acids Pt. II Deck (36):
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Adenosine Degredation

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Guanosine Degredation 

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Treatments for Gout

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Uricase

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Xanthine Oxidase

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Gout: Hyperuricemia 

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Lesch Nyhan Syndrome

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Adenosine Deaminase Deficiency 

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PNP Deficiency 

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Carbon Sources for Pyrimidine

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Pyrimidine Biosynthesis

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Which one of the following is a precursor for both purine and pyrimidine biosynthesis?

PRPP

Aspartate

Ammonia

Glycine

Carbon Dioxide 

Which one of the following is a precursor for both purine and pyrimidine biosynthesis?

PRPP

Aspartate — Donates Nitrogen on carbon 1

Ammonia

Glycine

Carbon Dioxide 

 

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Dihydroorotate Synthesis 

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UMP Synthesis 

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Synthesis of UTP and CTP

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The UTP to CTP reaction is similar to:

Imp to AMP

IMP to CMP

IMP to XMP

XMP to GMP 

XMP to UMP

The UTP to CTP reaction is similar to:

Imp to AMP

IMP to CMP

IMP to XMP

XMP to GMP — Requires Glutamine as a Nitrogen Source

XMP to UMP

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Biosynthesis of Deoxyribonucleotides

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Regulation of Ribonucleotide Reductase

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Preferred Substrate

Effector at Overall Activity Site

Effector at Substrate Specificity Site

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Ribonucleotide Reductase Rationale for Regulation

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Synthesis of dTMP

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Thymidylate Synthase

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Adensoine Deaminase Deficiency 

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Pyrimidine Base Salvage

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Pyrimidine Catabolism 

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Hereditary Orotic Aciduria

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One Carbon Metabolism 

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Tetrahydrofolate

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Why are folates important?

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Folate Analogs

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How do Folate Analogs kill Dividing Cells?

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Azaserine

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5-Flourouracil

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Methotrexate

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People with G6PDH deficiency shouldn’t take Sulfonamide. 

Which one of the pathways would not be inhibited by Azaserine?

Inosine Biosynthesis 

Orotic Acid Biosynthesis

GMP Synthesis from IMP

AMP Synthesis from IMP 

CTP Synthesis from UTP

People with G6PDH deficiency shouldn’t take Sulfonamide. 

Which one of the pathways would not be inhibited by Azaserine?

Inosine Biosynthesis 

Orotic Acid Biosynthesis

GMP Synthesis from IMP

AMP Synthesis from IMP — Requires aspartate instead, every other pathway requires glutamine. 

CTP Synthesis from UTP

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Case Study 

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Adenosine Deaminase Deficiency — Deoxyadensine accumulates and causes problems. 

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