Adenosine Degredation
Guanosine Degredation
Treatments for Gout
Uricase
Xanthine Oxidase
Gout: Hyperuricemia
Lesch Nyhan Syndrome
Adenosine Deaminase Deficiency
PNP Deficiency
Carbon Sources for Pyrimidine
Pyrimidine Biosynthesis
Which one of the following is a precursor for both purine and pyrimidine biosynthesis?
PRPP
Aspartate
Ammonia
Glycine
Carbon Dioxide
Which one of the following is a precursor for both purine and pyrimidine biosynthesis?
PRPP
Aspartate — Donates Nitrogen on carbon 1
Ammonia
Glycine
Carbon Dioxide
Dihydroorotate Synthesis
UMP Synthesis
Synthesis of UTP and CTP
The UTP to CTP reaction is similar to:
Imp to AMP
IMP to CMP
IMP to XMP
XMP to GMP
XMP to UMP
The UTP to CTP reaction is similar to:
Imp to AMP
IMP to CMP
IMP to XMP
XMP to GMP — Requires Glutamine as a Nitrogen Source
XMP to UMP
Biosynthesis of Deoxyribonucleotides
Regulation of Ribonucleotide Reductase
Preferred Substrate
Effector at Overall Activity Site
Effector at Substrate Specificity Site
Ribonucleotide Reductase Rationale for Regulation
Synthesis of dTMP
Thymidylate Synthase
Adensoine Deaminase Deficiency
Pyrimidine Base Salvage
Pyrimidine Catabolism
Hereditary Orotic Aciduria
One Carbon Metabolism
Tetrahydrofolate
Why are folates important?
Folate Analogs
How do Folate Analogs kill Dividing Cells?
Azaserine
5-Flourouracil
Methotrexate
People with G6PDH deficiency shouldn’t take Sulfonamide.
Which one of the pathways would not be inhibited by Azaserine?
Inosine Biosynthesis
Orotic Acid Biosynthesis
GMP Synthesis from IMP
AMP Synthesis from IMP
CTP Synthesis from UTP
People with G6PDH deficiency shouldn’t take Sulfonamide.
Which one of the pathways would not be inhibited by Azaserine?
Inosine Biosynthesis
Orotic Acid Biosynthesis
GMP Synthesis from IMP
AMP Synthesis from IMP — Requires aspartate instead, every other pathway requires glutamine.
CTP Synthesis from UTP
Case Study
Adenosine Deaminase Deficiency — Deoxyadensine accumulates and causes problems.