Signal Transduction Flashcards Preview

Fundamentals of Molecular Medicine > Signal Transduction > Flashcards

Flashcards in Signal Transduction Deck (54):
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Topics

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Fundamentals of Molecular Medicine

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What is Cancer?

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Percent Distribution of Cancer

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Cancer Death Rates

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Cancer Rates/Trends

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Cancer Treatment Types

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Distribution of Cancer Sites

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Erythropoetin and JAK-STAT Transduction 

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Erythroid Hyperplasia in Bone Marrow

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Normal Cells and Signaling Events

 

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Serum and Cells that are starved from Serum

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Cyclohexamide

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Immediate Early Proteins and Delayed Early Genes

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James Bond Model of Cancer

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Oncogenes

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Selected Oncogenes and Their Mode of Activation 

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Oncogenes and RAS

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RAS and Cancer

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Receptor that Activates RAS

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Paracrine Growth Factors

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Autocrine Growth Factors

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Antibodies and Cancer Therapies

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Herceptin 

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Blood Brain Barrier and Cancer

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Steroid Hormones

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RAS activation favors...

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MYC and Cyclin D

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Cyclin D

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Retinoblastoma and Cancer 

Which Cell Cycle is Effected?

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Constitutive Activation 

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Mode of Activation of Selected Oncogenes

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Result of Constitutive Activation 

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Constitutively Activated Receptors in Cancer

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RAS and Point Mutations

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RAS Point Mutations And Downstream Kinases

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Effects of RAS Activation/Point Mutation 

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mTOR

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Function of mTOR

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Rapamycin Derative and Tumors

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Complexity of mTOR Interactions

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ABL 

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ABL Translocation 

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BCR ABL and Gleevec

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Polycythemia

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Jakafi

50

 

 

 

Proteosome

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Cachexia and Inhibitors of Proteosomes

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Velcade

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Two Ways to Reduce Cell Cancer Growth 

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Getting Cancer Treatments into The Body

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