Topics
Fundamentals of Molecular Medicine
What is Cancer?
Percent Distribution of Cancer
Cancer Death Rates
Cancer Rates/Trends
Cancer Treatment Types
Distribution of Cancer Sites
Erythropoetin and JAK-STAT Transduction
Erythroid Hyperplasia in Bone Marrow
Normal Cells and Signaling Events
Serum and Cells that are starved from Serum
Cyclohexamide
Immediate Early Proteins and Delayed Early Genes
James Bond Model of Cancer
Oncogenes
Selected Oncogenes and Their Mode of Activation
Oncogenes and RAS
RAS and Cancer
Receptor that Activates RAS
Paracrine Growth Factors
Autocrine Growth Factors
Antibodies and Cancer Therapies
Herceptin
Blood Brain Barrier and Cancer
Steroid Hormones
RAS activation favors…
MYC and Cyclin D
Cyclin D
Retinoblastoma and Cancer
Which Cell Cycle is Effected?
Constitutive Activation
Mode of Activation of Selected Oncogenes
Result of Constitutive Activation
Constitutively Activated Receptors in Cancer
RAS and Point Mutations
RAS Point Mutations And Downstream Kinases
Effects of RAS Activation/Point Mutation
mTOR
Function of mTOR
Rapamycin Derative and Tumors
Complexity of mTOR Interactions
ABL
ABL Translocation
BCR ABL and Gleevec
Polycythemia
Jakafi
Proteosome
Cachexia and Inhibitors of Proteosomes
Velcade
Two Ways to Reduce Cell Cancer Growth
Getting Cancer Treatments into The Body