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Fundamentals of Molecular Medicine > The Nucleus > Flashcards

Flashcards in The Nucleus Deck (40):
1

 

 

 

RBC’s don’t have...

 

 

 

RBC’s don’t have nuclei

2

 

 

 

What type of image is this?

Identify nm, c, n, and f

3

 

 

 

Compartmentalization of Nucleus

 

 

 

Compartmentalization of Nucleus allows us to control reactions in comparison to those in the cytoplasm. 

4

 

 

 

Are there any organelles in the Nucleus?

 

 

 

No Organelles in the nucleus

5

 

 

 

Nucleolous is where...

 

 

 

Nucleolus = Where ribosomes are synthesized.

6

 

 

 

7

 

 

 

How Can we determine the location of proteins and whether or not they are inside or outside the nucleus?

8

 

 

What is the function and Structure of the Nuclear Lamina?

9

 

 

 

Describe the structure of what's in the image.

10

 

 

 

What are lamin associated diseases?

 

 

 

Mutations in different lamins lead to different disease.

11

 

 

 

Hutchinson Gifford Progeria Syndrome 

 

 

HGPS — Premature aging

Aging Phenotype

12

 

 

 

Describe the occurance in the electron micrograph.

13

 

 

 

Describe the Steps of the Nuclear Lamina in Mitosis 

14

 

 

 

Identify relavent structure from the image.

15

16

17

 

 

 

Central Granual

 

 

 

Central Granual is a filler in the middle of the pore. Some pores have channels some have central granule. 

18

 

 

 

Structure of the Nuclear Pore Complex

19

 

 

 

Function of the Nuclear Pore Complex

20

 

 

 

Nuclear Pore/Sieve Analogy

21

 

 

 

Nuclear Import

22

 

 

 

Nuclear Localization Sequence

23

24

25

 

 

 

Features of the NLS

 

 

 

NLS is essential and sufficient to allow proteins to be brought into the nucleus. 

26

 

 

 

Describe the process of Nuclear Import

27

 

 

 

Describe the process of Nuclear Export

28

 

 

 

Nuclear Export Sequence

29

 

 

 

Classes of nuclear proteins that need to be exported

30

31

 

 

 

How does nuclear import and export work?

32

 

 

 

GTP hydrolysis in Nuclear Import

33

 

 

 

GTP Hydrolysis in Nuclear Export

34

 

 

 

Difference between GTP hydrolysis in export vs. import

35

 

 

 

Nuclear Export of mRNA

36

 

 

 

Describe the results and design of this experiment

37

 

 

 

Substances contained in the nucleus.

Are they membrane bound?

38

 

 

 

 

39

 

 

 

Nucleolous 

40

 

 

 

Additional Subnuclear Bodies

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