The Nucleus Flashcards Preview

Fundamentals of Molecular Medicine > The Nucleus > Flashcards

Flashcards in The Nucleus Deck (40):
1

 

 

 

RBC’s don’t have...

 

 

 

RBC’s don’t have nuclei

2

 

 

 

What type of image is this?

Identify nm, c, n, and f

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Compartmentalization of Nucleus

 

 

 

Compartmentalization of Nucleus allows us to control reactions in comparison to those in the cytoplasm. 

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Are there any organelles in the Nucleus?

 

 

 

No Organelles in the nucleus

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Nucleolous is where...

 

 

 

Nucleolus = Where ribosomes are synthesized.

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7

 

 

 

How Can we determine the location of proteins and whether or not they are inside or outside the nucleus?

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8

 

 

What is the function and Structure of the Nuclear Lamina?

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9

 

 

 

Describe the structure of what's in the image.

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10

 

 

 

What are lamin associated diseases?

 

 

 

Mutations in different lamins lead to different disease.

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11

 

 

 

Hutchinson Gifford Progeria Syndrome 

 

 

HGPS — Premature aging

Aging Phenotype

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12

 

 

 

Describe the occurance in the electron micrograph.

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13

 

 

 

Describe the Steps of the Nuclear Lamina in Mitosis 

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14

 

 

 

Identify relavent structure from the image.

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15

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16

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17

 

 

 

Central Granual

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Central Granual is a filler in the middle of the pore. Some pores have channels some have central granule. 

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Structure of the Nuclear Pore Complex

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19

 

 

 

Function of the Nuclear Pore Complex

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20

 

 

 

Nuclear Pore/Sieve Analogy

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21

 

 

 

Nuclear Import

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22

 

 

 

Nuclear Localization Sequence

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23

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24

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25

 

 

 

Features of the NLS

 

 

 

NLS is essential and sufficient to allow proteins to be brought into the nucleus. 

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26

 

 

 

Describe the process of Nuclear Import

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27

 

 

 

Describe the process of Nuclear Export

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28

 

 

 

Nuclear Export Sequence

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29

 

 

 

Classes of nuclear proteins that need to be exported

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30

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31

 

 

 

How does nuclear import and export work?

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32

 

 

 

GTP hydrolysis in Nuclear Import

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33

 

 

 

GTP Hydrolysis in Nuclear Export

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34

 

 

 

Difference between GTP hydrolysis in export vs. import

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35

 

 

 

Nuclear Export of mRNA

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36

 

 

 

Describe the results and design of this experiment

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37

 

 

 

Substances contained in the nucleus.

Are they membrane bound?

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38

 

 

 

 

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39

 

 

 

Nucleolous 

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40

 

 

 

Additional Subnuclear Bodies

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Decks in Fundamentals of Molecular Medicine Class (77):