Pharmacokinetics Pt. II
Equations in Pharmacokinetics Pt. II
Start of Infusion and Wash Out
Continuous Infusion
T1/2 and Final Destination
Relationship between steady state concentration and infusion rate
Steady State
What was wrong with this Problem
What does approaching Steady State Depend on?
Loading Dose
Advantages/Disadvantages of Loading Dose
Discontinous Dosing
Variation in Drug Concentration with Dosing Interval
Tau vs. [Steady State Min]/[Steady State Max]
Average Steady State Concentration During Intermittent Dosing
Tau vs. Swings in [Drug]
Goals in Adjusting Dosing Regimen
Case I: High Therapuetic Index and Intermediate t1/2
Case II: t1/2 is long (>24hrs)
Case III: Short t1/2 or low Therapuetic Index
Calculate K0 and Dl
Variation in Clearance and Vd from Patient to Patient