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Fundamentals of Molecular Medicine > Pharmacokinetics Pt. II > Flashcards

Flashcards in Pharmacokinetics Pt. II Deck (24):
1

 

 

 

Pharmacokinetics Pt. II

2

 

 

 

Equations in Pharmacokinetics Pt. II

3

 

 

 

Start of Infusion and Wash Out

4

 

 

 

Continuous Infusion 

5

 

 

 

T1/2 and Final Destination 

6

 

 

 

Relationship between steady state concentration and infusion rate

7

 

 

 

Steady State

8

 

 

 

What was wrong with this Problem

9

 

 

 

What does approaching Steady State Depend on?

10

 

 

 

Loading Dose

11

 

 

 

Advantages/Disadvantages of Loading Dose

12

 

 

 

Discontinous Dosing

13

 

 

 

Variation in Drug Concentration with Dosing Interval

14

 

 

 

Tau vs. [Steady State Min]/[Steady State Max]

15

 

 

 

Average Steady State Concentration During Intermittent Dosing

16

 

 

 

Tau vs. Swings in [Drug]

17

 

 

 

Goals in Adjusting Dosing Regimen

18

 

 

 

Case I: High Therapuetic Index and Intermediate t1/2

19

 

 

 

Case II: t1/2 is long (>24hrs)

20

 

 

 

Case III: Short t1/2 or low Therapuetic Index

21

 

 

 

 

 

22

 

 

 

Calculate K0 and Dl

23

24

 

 

 

Variation in Clearance and Vd from Patient to Patient

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