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Fundamentals of Molecular Medicine > DNA Replication > Flashcards

Flashcards in DNA Replication Deck (21)
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1
Q

What is semi-conservative replicaiton?

What is the function of a replication fork?

A
2
Q

Origins of Replication

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3
Q

How does the old replication theory violate semi-conservative replication?

A
4
Q

Events at the Replication Fork

A
5
Q

Template strand for the leading strand is always

A

Is the template strand for leading strand is always 3’ to 5’ going into the fork

6
Q

The template for Lagging strand is always…

A

The template for Lagging strand is always 5’ to 3’ going into the fork

7
Q

Discontinuous synthesis

A

Discontinuous synthesis — Okazaki Fragments — Lagging Strand

8
Q

Okazaki Fragments move opposite direction of the…

A

Leading strand.

Okazaki Fragments move out of the fork!

9
Q

DNA Polymerase I

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10
Q

DNA Ligase

A
11
Q

Inverse Symmetry of Leading and Lagging Strands in Replication fork

A
12
Q

Forming and growing the bidirectional DNA Replication Bubble

A
13
Q

Image Type?

Significance?

A
14
Q

Proof Reading

A
15
Q

Eukaryotic Replication vs. Prokaryotic Replication

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16
Q

How does Replication Deal with the Unwinding Problem?

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17
Q

Eukaryotic Chromosomes vs. Prokaryotic Chromosomes

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18
Q

Telomeres Lagging Strand Replication Problem

A
19
Q

Solving the problem of incomplete replication of telomeres

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20
Q

Telomerase in Disease, Aging, and Cancer

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21
Q

Take Home Points

A

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