DNA Replication Flashcards Preview

Fundamentals of Molecular Medicine > DNA Replication > Flashcards

Flashcards in DNA Replication Deck (21):
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What is semi-conservative replicaiton?

What is the function of a replication fork?

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Origins of Replication 

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How does the old replication theory violate semi-conservative replication?

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Events at the Replication Fork

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Template strand for the leading strand is always 

 

 

 

Is the template strand for leading strand is always 3’ to 5’ going into the fork

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The template for Lagging strand is always...

 

 

 

The template for Lagging strand is always 5’ to 3’ going into the fork

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Discontinuous synthesis

 

 

 

Discontinuous synthesis — Okazaki Fragments — Lagging Strand

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Okazaki Fragments move opposite direction of the...

 

 

 

Leading strand.

Okazaki Fragments move out of the fork!

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DNA Polymerase I

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10

 

 

 

DNA Ligase

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Inverse Symmetry of Leading and Lagging Strands in Replication fork

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Forming and growing the bidirectional DNA Replication Bubble

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Image Type? 

Significance?

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14

 

 

 

Proof Reading

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15

 

 

 

Eukaryotic Replication vs. Prokaryotic Replication 

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How does Replication Deal with the Unwinding Problem?

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Eukaryotic Chromosomes vs. Prokaryotic Chromosomes

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Telomeres Lagging Strand Replication Problem

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Solving the problem of incomplete replication of telomeres

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20

 

 

 

Telomerase in Disease, Aging, and Cancer

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21

 

 

 

Take Home Points

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