What is semi-conservative replicaiton?
What is the function of a replication fork?
Origins of Replication
How does the old replication theory violate semi-conservative replication?
Events at the Replication Fork
Template strand for the leading strand is always
Is the template strand for leading strand is always 3’ to 5’ going into the fork
The template for Lagging strand is always...
The template for Lagging strand is always 5’ to 3’ going into the fork
Discontinuous synthesis — Okazaki Fragments — Lagging Strand
Okazaki Fragments move opposite direction of the...
Okazaki Fragments move out of the fork!
DNA Polymerase I
Inverse Symmetry of Leading and Lagging Strands in Replication fork
Forming and growing the bidirectional DNA Replication Bubble
Eukaryotic Replication vs. Prokaryotic Replication
How does Replication Deal with the Unwinding Problem?
Eukaryotic Chromosomes vs. Prokaryotic Chromosomes
Telomeres Lagging Strand Replication Problem
Solving the problem of incomplete replication of telomeres
Telomerase in Disease, Aging, and Cancer
Take Home Points