DNA Replication Flashcards Preview

Fundamentals of Molecular Medicine > DNA Replication > Flashcards

Flashcards in DNA Replication Deck (21):
1

 

 

What is semi-conservative replicaiton?

What is the function of a replication fork?

2

 

 

 

Origins of Replication 

3

 

 

 

How does the old replication theory violate semi-conservative replication?

4

 

 

 

Events at the Replication Fork

5

 

 

 

Template strand for the leading strand is always 

 

 

 

Is the template strand for leading strand is always 3’ to 5’ going into the fork

6

 

 

 

The template for Lagging strand is always...

 

 

 

The template for Lagging strand is always 5’ to 3’ going into the fork

7

 

 

 

Discontinuous synthesis

 

 

 

Discontinuous synthesis — Okazaki Fragments — Lagging Strand

8

 

 

 

Okazaki Fragments move opposite direction of the...

 

 

 

Leading strand.

Okazaki Fragments move out of the fork!

9

 

 

 

DNA Polymerase I

10

 

 

 

DNA Ligase

11

 

 

 

Inverse Symmetry of Leading and Lagging Strands in Replication fork

12

 

 

Forming and growing the bidirectional DNA Replication Bubble

13

 

 

 

Image Type? 

Significance?

14

 

 

 

Proof Reading

15

 

 

 

Eukaryotic Replication vs. Prokaryotic Replication 

16

 

 

 

How does Replication Deal with the Unwinding Problem?

17

 

 

 

Eukaryotic Chromosomes vs. Prokaryotic Chromosomes

18

 

 

 

Telomeres Lagging Strand Replication Problem

19

 

 

 

Solving the problem of incomplete replication of telomeres

20

 

 

 

Telomerase in Disease, Aging, and Cancer

21

 

 

 

Take Home Points

Decks in Fundamentals of Molecular Medicine Class (77):