Inf&Imm_H14a (D5) Flashcards by Anne-Marie Clissen

Q

soort antibioticum fluorchinolonen

A

concentratieafhankelijk
bactericide

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Q

werking fluorchinolonen

A

interfereren met DNA synthese

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Q

Interferentie met DNA gyrase

A

vnl gram-

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Q

interferentie met topoisomerase IV

A

vnl gram+

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Q

biologische beschikbaarheid van fluorchinolonen

A

hoog dus ze worden bij voorkeur oraal gegeven

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Q

algemeen werkingsspectrum van fluorchinolonen

A

gram+
gram-

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Q

indeling van fluorchinolonen

A

generaties afh van werkingsspectrum

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Q

1ste generatie fluorchinolonen

A

ciprofloxacine

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Q

2de generatie fluorchinolonen

A

moxifloxaxine

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Q

3de generatie fluorchinolonen

A

levofloxacine

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Q

4de generatie fluorchinolonen

A

moxifloxacine

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Q

gebruik 1ste generatie fluorchinolonen

A

(ciprofloxacine)
behandeling van ongecompliceerd UWI
NIET tegen pneumokokken

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Q

gebruik 2de generatie fluorchinolonen

A

(moxifloxacine)
gecompliceerde UWI
GI-infecties
NIET tegen pneumokokken

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Q

gebruik 3de generatie fluorchinolonen

A

(levofloxacine)
pneumokokken

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Q

gebruik 4de generatie fluorchinolonen

A

(moxifloxacine)
pneomokokken

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Q

specifieke indicatie fluorchinolonen

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A

atypische pneumonie

Q

bijwerkingen langdurige behandeling met fluorchinolonen

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A

peesontsteking
verwardheid
fototoxiciteit

Q

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A