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AMC > Inf&Imm_H15 (D5) > Flashcards

Inf&Imm_H15 (D5) Flashcards

(8 cards)

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1
Q

SLE, orgaanspecifiek

A

nee, systemisch

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2
Q

SLE afkorting

A

systemische lupus erythematosus

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3
Q

SLE, klinische tekens

A

huid, gewricht en nier- aantasting

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4
Q

SLE, type overgevoeligheid

A

type III

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5
Q

SLE, genetische voorbeschiktheid

A

HLA-DR2

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6
Q

SLE, andere voorbeschikkende factoren

A
  • vrouw zijn (oestrogeen)
  • UV-licht
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7
Q

Ontstaansmechanisme SLE

A
  • Geen efficiënte opruiming van DNA dat vrijgekomen is door apoptose (MBL en C1 werken niet goed)
  • het vrijgekomen DNA vormt immuuncomplexen met IgG
  • TLR9 (B-cel) herkent die immuuncomplexen
  • Verhoogde afgifte type I IFN en extra stimulatie voor B-cellen
  • voortdurende productie van anti-DNA antilichamen
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8
Q

SLE GM

A
  • hydralazine
  • procainamide
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