Blood Porducts Flashcards
(150 cards)
1
Q
What is the typical lifespan of red blood cells in vivo?
A
About 120 days
2
Q
How long do transfused red blood cells last?
A
Around 50–60 days
3
Q
At what temperature is fresh frozen plasma (FFP) stored?
A
–30 °C
4
Q
What is the shelf life of fresh frozen plasma (FFP)?
A
1 year
5
Q
What is the primary use of fresh frozen plasma (FFP)?
A
To replace clotting factors in patients with coagulopathy
6
Q
What influences the type of FFP used in patients?
A
The patient’s blood group
7
Q
At what temperature are platelets stored?
A
Room temperature
8
Q
What is the shelf life of platelets?
A
Up to 7 days
9
Q
What is the lifespan of platelets before phagocytosis?
A
10 days
10
Q
How many donors typically contribute to one pool of platelets?
A
4 donors
11
Q
What platelet count threshold indicates the need for platelet transfusion in thrombocytopenia?
A
<10 x 10^9/l
12
Q
Under what conditions should platelet transfusions not be used?
A
In immune destruction of platelets, TTP, or HUS
13
Q
What is cryoprecipitate made from?
A
Thawing fresh frozen plasma (FFP)
14
Q
What is the shelf life of cryoprecipitate when stored at –30 °C?
A
1 year
15
Q
What components does cryoprecipitate contain?
A
- Fibrinogen
- Factor VIII
- Von Willebrand factor
16
Q
In what situation is cryoprecipitate generally used?
A
In patients with massive bleeding and low fibrinogen
17
Q
What causes transfusion-associated graft-versus-host disease?
A
Donor blood lymphocytes attacking the recipient’s body
18
Q
Is transfusion-associated graft-versus-host disease common or rare?
A
Rare but carries a high risk of mortality
19
Q
What is iron overload related to?
A
- Pathophysiology of conditions (e.g., haemochromatosis)
- Iatrogenic causes (e.g., blood transfusion, excess oral iron)
20
Q
How much iron is lost via gut mucosal cells?
A
Approximately 1 mg
21
Q
What mediates the absorption of luminal iron?
A
Enterocytes
22
Q
What regulates transferrin uptake from plasma?
A
Transferrin receptor on enterocytes
23
Q
What protein modulates transferrin receptor activity?
A
HFE protein
24
Q
When does iron overload usually become an issue?
A
After 20 units have been given or if serum ferritin rises above 1000 µg/l
25
What treatment is required to lower iron levels in cases of overload?
Subcutaneous desferrioxamine
26
What is the typical lifespan of red blood cells in vivo?
About 120 days
27
How long do transfused red blood cells last?
Around 50–60 days
28
At what temperature is fresh frozen plasma (FFP) stored?
–30 °C
29
What is the shelf life of fresh frozen plasma (FFP)?
1 year
30
What is the primary use of fresh frozen plasma (FFP)?
To replace clotting factors in patients with coagulopathy
31
What influences the type of FFP used in patients?
The patient's blood group
32
At what temperature are platelets stored?
Room temperature
33
What is the shelf life of platelets?
Up to 7 days
34
What is the lifespan of platelets before phagocytosis?
10 days
35
How many donors typically contribute to one pool of platelets?
4 donors
36
What platelet count threshold indicates the need for platelet transfusion in thrombocytopenia?
<10 x 10^9/l
37
Under what conditions should platelet transfusions not be used?
In immune destruction of platelets, TTP, or HUS
38
What is cryoprecipitate made from?
Thawing fresh frozen plasma (FFP)
39
What is the shelf life of cryoprecipitate when stored at –30 °C?
1 year
40
What components does cryoprecipitate contain?
* Fibrinogen
* Factor VIII
* Von Willebrand factor
41
In what situation is cryoprecipitate generally used?
In patients with massive bleeding and low fibrinogen
42
What causes transfusion-associated graft-versus-host disease?
Donor blood lymphocytes attacking the recipient's body
43
Is transfusion-associated graft-versus-host disease common or rare?
Rare but carries a high risk of mortality
44
What is iron overload related to?
* Pathophysiology of conditions (e.g., haemochromatosis)
* Iatrogenic causes (e.g., blood transfusion, excess oral iron)
45
How much iron is lost via gut mucosal cells?
Approximately 1 mg
46
What mediates the absorption of luminal iron?
Enterocytes
47
What regulates transferrin uptake from plasma?
Transferrin receptor on enterocytes
48
What protein modulates transferrin receptor activity?
HFE protein
49
When does iron overload usually become an issue?
After 20 units have been given or if serum ferritin rises above 1000 µg/l
50
What treatment is required to lower iron levels in cases of overload?
Subcutaneous desferrioxamine
51
What is the typical lifespan of red blood cells in vivo?
About 120 days
51
What is the typical lifespan of red blood cells in vivo?
About 120 days
52
How long do transfused red blood cells last?
Around 50–60 days
52
How long do transfused red blood cells last?
Around 50–60 days
53
At what temperature is fresh frozen plasma (FFP) stored?
–30 °C
53
At what temperature is fresh frozen plasma (FFP) stored?
–30 °C
54
What is the shelf life of fresh frozen plasma (FFP)?
1 year
54
What is the shelf life of fresh frozen plasma (FFP)?
1 year
55
What is the primary use of fresh frozen plasma (FFP)?
To replace clotting factors in patients with coagulopathy
55
What is the primary use of fresh frozen plasma (FFP)?
To replace clotting factors in patients with coagulopathy
56
What influences the type of FFP used in patients?
The patient's blood group
56
What influences the type of FFP used in patients?
The patient's blood group
57
At what temperature are platelets stored?
Room temperature
57
At what temperature are platelets stored?
Room temperature
58
What is the shelf life of platelets?
Up to 7 days
58
What is the shelf life of platelets?
Up to 7 days
59
What is the lifespan of platelets before phagocytosis?
10 days
59
What is the lifespan of platelets before phagocytosis?
10 days
60
How many donors typically contribute to one pool of platelets?
4 donors
60
How many donors typically contribute to one pool of platelets?
4 donors
61
What platelet count threshold indicates the need for platelet transfusion in thrombocytopenia?
<10 x 10^9/l
61
What platelet count threshold indicates the need for platelet transfusion in thrombocytopenia?
<10 x 10^9/l
62
Under what conditions should platelet transfusions not be used?
In immune destruction of platelets, TTP, or HUS
62
Under what conditions should platelet transfusions not be used?
In immune destruction of platelets, TTP, or HUS
63
What is cryoprecipitate made from?
Thawing fresh frozen plasma (FFP)
63
What is cryoprecipitate made from?
Thawing fresh frozen plasma (FFP)
64
What is the shelf life of cryoprecipitate when stored at –30 °C?
1 year
64
What is the shelf life of cryoprecipitate when stored at –30 °C?
1 year
65
What components does cryoprecipitate contain?
* Fibrinogen
* Factor VIII
* Von Willebrand factor
65
What components does cryoprecipitate contain?
* Fibrinogen
* Factor VIII
* Von Willebrand factor
66
In what situation is cryoprecipitate generally used?
In patients with massive bleeding and low fibrinogen
66
In what situation is cryoprecipitate generally used?
In patients with massive bleeding and low fibrinogen
67
What causes transfusion-associated graft-versus-host disease?
Donor blood lymphocytes attacking the recipient's body
67
What causes transfusion-associated graft-versus-host disease?
Donor blood lymphocytes attacking the recipient's body
68
Is transfusion-associated graft-versus-host disease common or rare?
Rare but carries a high risk of mortality
68
Is transfusion-associated graft-versus-host disease common or rare?
Rare but carries a high risk of mortality
69
What is iron overload related to?
* Pathophysiology of conditions (e.g., haemochromatosis)
* Iatrogenic causes (e.g., blood transfusion, excess oral iron)
69
What is iron overload related to?
* Pathophysiology of conditions (e.g., haemochromatosis)
* Iatrogenic causes (e.g., blood transfusion, excess oral iron)
70
How much iron is lost via gut mucosal cells?
Approximately 1 mg
70
How much iron is lost via gut mucosal cells?
Approximately 1 mg
71
What mediates the absorption of luminal iron?
Enterocytes
71
What mediates the absorption of luminal iron?
Enterocytes
72
What regulates transferrin uptake from plasma?
Transferrin receptor on enterocytes
72
What regulates transferrin uptake from plasma?
Transferrin receptor on enterocytes
73
What protein modulates transferrin receptor activity?
HFE protein
73
What protein modulates transferrin receptor activity?
HFE protein
74
When does iron overload usually become an issue?
After 20 units have been given or if serum ferritin rises above 1000 µg/l
74
When does iron overload usually become an issue?
After 20 units have been given or if serum ferritin rises above 1000 µg/l
75
What treatment is required to lower iron levels in cases of overload?
Subcutaneous desferrioxamine
75
What treatment is required to lower iron levels in cases of overload?
Subcutaneous desferrioxamine
76
What is the typical lifespan of red blood cells in vivo?
About 120 days
76
What is the typical lifespan of red blood cells in vivo?
About 120 days
77
How long do transfused red blood cells last?
Around 50–60 days
77
How long do transfused red blood cells last?
Around 50–60 days
78
At what temperature is fresh frozen plasma (FFP) stored?
–30 °C
78
At what temperature is fresh frozen plasma (FFP) stored?
–30 °C
79
What is the shelf life of fresh frozen plasma (FFP)?
1 year
79
What is the shelf life of fresh frozen plasma (FFP)?
1 year
80
What is the primary use of fresh frozen plasma (FFP)?
To replace clotting factors in patients with coagulopathy
80
What is the primary use of fresh frozen plasma (FFP)?
To replace clotting factors in patients with coagulopathy
81
What influences the type of FFP used in patients?
The patient's blood group
81
What influences the type of FFP used in patients?
The patient's blood group
82
At what temperature are platelets stored?
Room temperature
82
At what temperature are platelets stored?
Room temperature
83
What is the shelf life of platelets?
Up to 7 days
83
What is the shelf life of platelets?
Up to 7 days
84
What is the lifespan of platelets before phagocytosis?
10 days
84
What is the lifespan of platelets before phagocytosis?
10 days
85
How many donors typically contribute to one pool of platelets?
4 donors
85
How many donors typically contribute to one pool of platelets?
4 donors
86
What platelet count threshold indicates the need for platelet transfusion in thrombocytopenia?
<10 x 10^9/l
86
What platelet count threshold indicates the need for platelet transfusion in thrombocytopenia?
<10 x 10^9/l
87
Under what conditions should platelet transfusions not be used?
In immune destruction of platelets, TTP, or HUS
87
Under what conditions should platelet transfusions not be used?
In immune destruction of platelets, TTP, or HUS
88
What is cryoprecipitate made from?
Thawing fresh frozen plasma (FFP)
88
What is cryoprecipitate made from?
Thawing fresh frozen plasma (FFP)
89
What is the shelf life of cryoprecipitate when stored at –30 °C?
1 year
89
What is the shelf life of cryoprecipitate when stored at –30 °C?
1 year
90
What components does cryoprecipitate contain?
* Fibrinogen
* Factor VIII
* Von Willebrand factor
90
What components does cryoprecipitate contain?
* Fibrinogen
* Factor VIII
* Von Willebrand factor
91
In what situation is cryoprecipitate generally used?
In patients with massive bleeding and low fibrinogen
91
In what situation is cryoprecipitate generally used?
In patients with massive bleeding and low fibrinogen
92
What causes transfusion-associated graft-versus-host disease?
Donor blood lymphocytes attacking the recipient's body
92
What causes transfusion-associated graft-versus-host disease?
Donor blood lymphocytes attacking the recipient's body
93
Is transfusion-associated graft-versus-host disease common or rare?
Rare but carries a high risk of mortality
93
Is transfusion-associated graft-versus-host disease common or rare?
Rare but carries a high risk of mortality
94
What is iron overload related to?
* Pathophysiology of conditions (e.g., haemochromatosis)
* Iatrogenic causes (e.g., blood transfusion, excess oral iron)
94
What is iron overload related to?
* Pathophysiology of conditions (e.g., haemochromatosis)
* Iatrogenic causes (e.g., blood transfusion, excess oral iron)
95
How much iron is lost via gut mucosal cells?
Approximately 1 mg
95
How much iron is lost via gut mucosal cells?
Approximately 1 mg
96
What mediates the absorption of luminal iron?
Enterocytes
96
What mediates the absorption of luminal iron?
Enterocytes
97
What regulates transferrin uptake from plasma?
Transferrin receptor on enterocytes
97
What regulates transferrin uptake from plasma?
Transferrin receptor on enterocytes
98
What protein modulates transferrin receptor activity?
HFE protein
98
What protein modulates transferrin receptor activity?
HFE protein
99
When does iron overload usually become an issue?
After 20 units have been given or if serum ferritin rises above 1000 µg/l
99
When does iron overload usually become an issue?
After 20 units have been given or if serum ferritin rises above 1000 µg/l
100
What treatment is required to lower iron levels in cases of overload?
Subcutaneous desferrioxamine
100
What treatment is required to lower iron levels in cases of overload?
Subcutaneous desferrioxamine
