PPT Hypertension And Fat Drugs Flashcards
(42 cards)
What is considered normotensive blood pressure?
BP of BELOW 135/85
What does it indicate if blood pressure does not dip at night by 10%?
May indicate underlying cause like sleep apnoea
When should hypertension medication be considered for people aged 60?
With stage 1 hypertension and CVD risk below 10%
What is the first line treatment for hypertension?
ACE inhibitors and ARBs OR CCBs
What is the second line treatment for hypertension?
CCB can be combined with RAASi (ARB or ACEi) or thiazide-like diuretic
What are the protective effects of ACE inhibitors?
Renoprotective and cardio protective
How do thiazides and thiazide-like diuretics work?
By inhibiting sodium and chloride reabsorption in the distal convoluted tubule of the kidney
What additional action can thiazide-like diuretics have?
Vasodilation (widening of blood vessels)
How long should be allowed to evaluate the therapeutic effect of a drug?
1 month
What is the starting dose of ACE inhibitors and the maximum benefit dose?
Starting dose is 2.5mg, titrate up to 10mg
What blood pressure levels should ACE inhibitors maintain?
At satisfactory level of 135/85 and 140/90
What risk do ACE inhibitors increase related to the kidneys?
Increase risk of AKI by affecting flow in glomerulus
In what conditions should ACE inhibitors be avoided?
Coarctation of aorta, Conn’s syndrome, Cushing’s syndrome, renal artery stenosis
What assessment is performed after 2 weeks of starting ACE inhibitors?
U&Es and GFR to assess for drug level
How do fibrates act in the body?
By stimulating PPAR-alpha dependent stimulation of lipoprotein lipase
What is the effect of fibrates on plasma HDL?
Increases plasma HDL
What side effects can fibrates cause?
Myalgia, rash or pruritis, GI upset
How do statins work?
By inhibiting HMG-coA reductase and increasing uptake of LDL receptor
Which statin is considered the best?
Atorvastatin
What is the action of ezetimibe?
Selective cholesterol-absorption inhibitor acting by down regulating NPC1L protein
How do bile acid resins function?
By interfering with bile acid absorption by binding to them
What is considered normotensive blood pressure?
BP of BELOW 135/85
What does it indicate if blood pressure does not dip at night by 10%?
May indicate underlying cause like sleep apnoea
When should hypertension medication be considered for people aged 60?
With stage 1 hypertension and CVD risk below 10%
