Passmed Flashcards

(51 cards)

1
Q

What does liver and neurological disease indicate?

A

Wilson’s disease

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2
Q

What is wiskott-Aldrich stroke?

A

X linked recessive disorder presents in infancy or early childhood with eczema, recurrent infections (due to immunodeficiency), and thrombocytopenia with small platelets leading to bleeding problems

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3
Q

What is friedreich’s ataxia?

A

Friedreich’s ataxia is a neurodegenerative disorder that typically presents before adolescence with progressive gait instability (ataxia), dysarthria, loss of deep tendon reflexes and hypertrophic cardiomyopathy

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4
Q

What investigation to confirm pancreatic cancer?

A

CT scan

-> faecal elastase is only for exocrine function

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5
Q

What i

A
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6
Q

What is used in management of oesophageal cancer early stage?

A

Surgical resection

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7
Q

What is performed in locally advanced prostate cancer?

A

Neoadjuvant chemoradiotherapy is used for locally advanced oesophageal cancer to downstage the tumour before surgery

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8
Q

What should be done if a patient has already tried topical aminosalicylate for UC and is currently on oral?

A

DO NOT DO HIGHER DOSE BECAUSE THEY ARE CLEARLY NOT RESPONDING

Try steroid

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9
Q

What causes a palpable pass in epigastric region and repeated superficial thrombophlebitis?

A

Pancreatitis which is associated with Trousseau’s causing migratory thrombophlebitis

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10
Q

What is Courvoisier’s law?

A

Painless obstructive jaundice with smooth non tender meats in RUQ is pancreatic cancer.

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11
Q

What is the LFT pattern for pancreatic cancer?

A

obstructive pattern with markedly elevated bilirubin and alkaline phosphatase (ALP)

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12
Q

What causes symptoms of diarrhoea, abomdinal pain and bloating to improve after taking antibiotics?

A

Small bacterial overgrowth syndorme

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13
Q

What is indicated for prophylaxis of variceal bleeding?p

A

Propanolol and Terlipressin

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14
Q

What is used to determine severity of C.diff?

A

white cell count

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15
Q

What are enteral features of lfe threatening i bwelo infections

A

hypotension, partial or complete ileus, toxic megacolon, or CT evidence of severe disease

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16
Q

WHAT IS TERLIPRESSIN?

A

VASOPRESSIN ANALOGUE

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17
Q

WHAT is alpha fto protein associated with?

A

Germ cell tumours
Hepatocellular carcinoma

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18
Q

When is urgent referral to hepatology indicated for NAFLD?S

A

USPECTED MAIGINACY

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19
Q

What is the anagement of acute mesenteric ischaemia?

A

Laparoscopy

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20
Q

What should be suspected in IBD and rigours, fever and sore throat sudden onset

A

Agranulocytosis with the use of masala zine which presents with sudden onset rigors, fever and sore throat

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21
Q

When are negative pressure rooms used?

A

Airborn communicable diseases ike tB

22
Q

How to differentiate between chronic pancreatitis and pancreatic cancer?

A

Chnic pancrreatititis repeated episodes of abdominal pain and often relates to chronic alcohol consumption or genetic predispositionsor

Pancreatic cancer has weight loss, recent onset diabetes and history fo smoking

23
Q

What does simultaneous dilation of common bile duct and pancreatic duct indicate?

A

Double duct sign seen in pancreatic cancer has weight

24
Q

What liver pathology occurs after cardiac arrest?

A

Ischaemic hepatitis which will show extremely high LAT

25
What to do for transverse cancer resection?
Transverse colectomy is ONLY for CENTRAL transverse colon tumour
26
What is the investigation of choice in primary sclerosing cholangitis?
MRCP/ERCP
27
When is wide local excision used?
Breast cancer
28
What TPMT level is safe to use Azathriopine or mercaptopurine?
Below normal but not deficient is minimum -> thiopurine methyltransferase is involved in metabolism
29
What is an alternative to azathriopine in Crohn’s remission?
Methotrexate when TPMT is high
30
What is used for perianal disease in Crohn;s?
Metronidazole
31
What is the investigation for suspected fistula ?
MRI -> simple fistulas are managed with infilimab -> complex fistulas managed with draining seton
32
Wha to do for dysplasia on biopsy in Barrett’s?
Endoscopic mucosal therapy
33
What is the test for H.pylori post-eradication?
Urea breath test
34
How is BRCA inherited?
It is autosomal dominant so children or sibling will have equal 50% chance
35
What to suspect in obesity with abnormal LFTs?
NAFLD
36
What is the threshold for iron haemochromatosis?
At least 40% transferrin increase Ferritin SEVERLY raised over 1000
37
What do coeliac patients require for prevention?
Pneumococcal vaccine due to hyposplenism
38
What does c diff positive mean?
Exposure unless there is C diff positive toxin
39
What is coeliac associated with cancer wise?
Bilateral inguinal lymphadenoapthy due to enteropathy associated T cell lymphoma
40
What blood gas finding is found in acute Mesenteric ischaemia?
Metabolic acidosis with partial respiration compensation pH 7.30, pO2 11.8 kPa, pCO2 4.2 kPa, HCO3 17 mmol/L:
41
Which values are monitored in haemochromatosis is venesection?
Ferritin and transferrin
42
What is Peabody’s sign?
Peabody's sign is clinically found in patients with a deep vein thrombosis (DVT) and a positive test indicated by calf muscle spasm occurring on elevation and foot extension of the affected leg
43
What is first line for haemorrhoids?
Increase fibre supplementation
44
What is done for asymptomatic gallstones?
Nothing- just reassurance
45
What is pernicious anaemia associated with?o
Ther autoimmune diseases like coeliac
46
Which antibody is raised in autoimmune hepatitis?
IgG
47
How does pancreatic cancer present on LFTs?
Cholestasis
48
Which drug for IBD has a pancreatitis risk?
Mesasalazine has greater risk than sulphasalazine
49
What is sudden weight loss associated with?
NAFLD exacerbation in obese patients, especially with metabolic syndrome
50
Is intrinsic factor or parietal cell antibiody more sensitive for pernicious anaemia?
Intrinsic factor
51
What is gold standard for achalasia?
Oesophageal manometry