Membranoproliferative Glomerulpmephritis Flashcards
(9 cards)
What is another name for mesangiocapillary glomerulonephritis?
Also known as mesangiocapillary glomerulonephritis
This condition may present with nephrotic syndrome, haematuria, or proteinuria and has a poor prognosis.
What percentage of cases does Type 1 mesangiocapillary glomerulonephritis account for?
Accounts for 90% of cases
The main causes include cryoglobulinaemia and hepatitis C.
What findings are observed in a renal biopsy for Type 1 mesangiocapillary glomerulonephritis?
Electron microscopy shows subendothelial and mesangium immune deposits of electron-dense material resulting in a ‘tram-track’ appearance
This appearance is characteristic of Type 1.
What is Type 2 mesangiocapillary glomerulonephritis also known as?
‘Dense deposit disease’
This type is associated with partial lipodystrophy and factor H deficiency.
What causes the persistent activation of the alternative complement pathway in Type 2 mesangiocapillary glomerulonephritis?
Caused by persistent activation of the alternative complement pathway
Patients typically have low circulating levels of C3.
What is the C3b nephritic factor and its significance in Type 2 mesangiocapillary glomerulonephritis?
C3b nephritic factor is found in 70% of cases
It is an antibody to alternative-pathway C3 convertase (C3bBb) that stabilizes C3 convertase.
What findings are observed in a renal biopsy for Type 2 mesangiocapillary glomerulonephritis?
Electron microscopy shows intramembranous immune complex deposits with ‘dense deposits’
This is characteristic of Type 2.
What causes Type 3 mesangiocapillary glomerulonephritis?
Causes: hepatitis B and C
This type is less common compared to Type 1.
What is a potential management option for mesangiocapillary glomerulonephritis?
Steroids may be effective
The effectiveness of steroids can vary based on the type and individual patient response.
