Inf&Imm_H23 (D1) Flashcards

(14 cards)

1
Q

aangrijpingspunten van immuunmodulatoire GM binnen het aangeboren immuunsysteem

A
  • Cytokines
  • Complementsysteem
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2
Q

aangrijpingspunten van immuunmodulatoire GM binnen het verworven immuunsysteem

A
  • T-cellen: activatie - migratie - depletie
  • B-cellen
  • Breed-werkend
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3
Q

anti TNF middelen

A
  • Etanercept
  • Infliximab
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4
Q

merk etanercept

A

enbrel

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5
Q

merk infliximab

A

remicade

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6
Q

werkingsmechanisme anti-TNF

A
  • (etanercept, infliximab)
  • inhibitie van TNF signaal
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7
Q

indicatie anti-TNF

A
  • (etanercept, infliximab)
  • RA
  • Inflammatoir darmlijden
  • Psoriasis
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8
Q

Neveneffecten van anti-TNF

A
  • (etanercept, infliximab)
  • Verhoogd risico op infecties
  • Reactivatie van infecties (bij latente infecties)
  • Ontwikkeling van SLE-beeld
  • Contra-indicaties voor levende vaccins
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9
Q

anti-IL1 middelen

A
  • anakinra
  • canakinumab
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10
Q

werkingsmechanisme anti-IL1 middelen

A
  • (anakinra, canakinumab)
  • inhibitie van het IL1 signaal
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11
Q

indicaties anti-IL1 middelen

A
  • (anakinra, canakinumab)
  • gewrichtslijden
  • auto-inflammatoire periodieke koortssyndromen
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12
Q

neveneffecten anti-IL1 middelen

A
  • (anakinra, canakinumab)
  • verhoogd risico op infecties
  • mogelijks verhoogd risico op kanker
  • contra-indicatie voor levend vaccin
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13
Q

werking anakinra

A

IL-1 receptor antagonist

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14
Q

werking canakinumab

A

monoklonaal antilichaam dat IL-1 bindt

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