Inf&Imm_H23 (D4) Flashcards

(21 cards)

1
Q

welke zijn lymfocyt depleterende antistoffen

A
  • anti-lymfocyt
  • anti-thymocyt
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2
Q

werkingsmechanisme van anti-lymfocyt en anti-thymocyt

A
  • depletie van lymfocyten
  • alle B- en T-cellen worden kapot gemaakt
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3
Q

indicatie anti-lymfocyt en anti-thymocyt

A

orgaantransplantatie

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4
Q

neveneffecten anti-lymfocyt en anti-thymocyt

A
  • type III overgevoeligheidsreactie: immuuncomplexen sloegen neer thv gewrichten, longen en nieren
  • verhoogde incidentie van kankers posttransplantatie
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5
Q

welke middelen werken in op de B-celproliferatie en differentiatie

A
  • Anti-CD20: rituximab
  • Anti-CD38: daratumumab
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6
Q

anti-CD20

A

Rituximab

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7
Q

merk rituximab

A

mabthera

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8
Q

werkingsmechanisme anti-CD20

A
  • rituximab
  • depletie van CD20+ B-cellen
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9
Q

indicatie anti-CD20

A
  • rituximab
  • AIZ
  • humorale afstoting
  • hematologische tumoren
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10
Q

neveneffecten anti-CD20

A
  • Rituximab
  • verhoogd risico op infecties
  • reactivatie van TBC
  • infusiereactie
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11
Q

anti-CD38

A

Daratumumab

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12
Q

Rituximab

A

anti-CD20

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13
Q

Daratumumab

A

anti-CD38

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14
Q

Werkingsmechanisme anti-CD38

A
  • Daratumumab
  • depletie van CD38+ plasmacellen
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15
Q

indicatie anti-CD38

A
  • daratumumab
  • hematologische tumoren
  • humorale afstoting
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16
Q

neveneffecten anti-CD38

A
  • daratumumab
  • verhoogd risico op infecties
  • transfusiereactie
17
Q

corticosteroïden

A

methylprednisolone

18
Q

merk methylprednisolone

19
Q

werkingsmechanisme corticosteroïden

A
  • methylprednisolone
  • breed immuun-modulerend effect
20
Q

indicaties corticosteroïden

A
  • methylprednisolone
  • AIZ
  • overgevoeligheidsreacties
  • transplantatie
21
Q

Neveneffecten corticosteroïden

A
  • Methylprednisolone
  • verhoogde glycemie
  • hypertensie
  • esthetische effecten: acne, moon facies, buffalo hump
  • spieratrofie
  • psychische effecten
  • osteoporose
  • verhoogd risico op infecties