Inf&Imm_H23 (D3) Flashcards

(13 cards)

1
Q

anti-metabolieten

A
  • mycofenolaat mofetil
  • azathioprine
  • methotrexaat
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2
Q

merk mycofenolaat mofetil

A

cellcept

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3
Q

werkingsmechanisme mycofenolaat mofetil

A
  • Inhibitie van T- en B-cellen
  • nieuwe aanmaak van purines remmen
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4
Q

indicatie van mycofenolaat mofetil

A
  • orgaantransplantatie
  • preventie/behandeling GVHD
  • AIZ
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5
Q

neveneffecten mycofenolaat mofetil

A
  • GI-intolerantie: misselijk, diarree
  • Myelosuppressie (neutropenie)
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6
Q

merk azathioprine

A

imuran

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7
Q

werkingsmechanisme azathioprine

A
  • Inhibitie van T- en B-cellen
  • inhibitie van purine nucleotide synthese
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8
Q

indicatie azathioprine

A
  • vroeger orgaantransplantatie
  • AIZ
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9
Q

Neveneffecten azathioprine

A
  • myelosuppressie: leukopenie, anemie, trombopenie
  • leverdysfunctie
  • drug interactie => allopurinol
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10
Q

werking methotrexaat

A
  • inhibitie van T- en B-cellen
  • inhibitie van dihydrofolaat reductase
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11
Q

indicatie methotrexaat

A
  • reumatologische aandoeningen
  • psoriasis
  • inflammatoire darmziekten
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12
Q

neveneffecten van methotrexaat

A
  • Myelosuppressie: leukopenie, anemie, trombopenie
  • leverdysfunctie
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13
Q

wat wordt er gegeven om neveneffecten van methotrexaat tegen te gaan

A

foliumzuur

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