Flashcards in 9.19 Injury, Inflammation, Healing 3 Deck (23)
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1
goal of tissue healing
restore function if possible
2
What is necessary for tissue return to function?
regeneration
3
tissue regeneration
- not possible in all tissue (neuron, cardiac muscle)
- new research is promising
4
repair of connective tissue
- scarring
- muscle fibrosis
5
repair: maintains integrity of the tissue but does NOT
function as original cells and tissues
6
components that help with the repair process
- fibronectin
- proteoglycan and elastin
- collagen
7
fibronectin
- tensile strength
- glue
8
proteoglycans and elastin
fibroblast proliferation
9
collagen
- fibrous protein
- structural support and tensile strength of tissue
10
What is the most important protein that provides structural support?
collagen
11
Factors that affect healing?
- growth factors
- vascular supply
- age, tissue health, disease, psychological status, alcohol, smoking, nutrition, tissue type, meds, etc.
12
What are the phases of healing?
1. hemostasis and degeneration phase
2. inflammation phase
3. proliferation and migration phase
4. remodeling and maturation phase
13
hemostasis and degeneration phase
- initiation phase
- stops bleeding
14
inflammation phase
prepares for healing
15
proliferation and migration phase
rebuilds and strengthens damaged tissue
16
remodeling and maturation phase
modifies tissue to mature form
17
How is bleeding stopped in the hemostasis and degeneration phase?
- immediately
- coagulation cascade
18
Coagulation cascade involves
- platelets
- growth factors
- proliferation and migration of epithelial cells
- fibroblasts
- vascular endothelial cells
19
What happens during degeneration?
- hematoma formed
- necrosis of dead cells
- inflammatory response of fluid, neutrophils, and macrophages begins
20
degeneration: tissue healing begins within
24 hours
21
degeneration: fibroblast migration
fibroblasts migrate from margins of viable tissue to the defect area
22
Proteins secreted during degeneration phase
- fibronectin
- proteoglycans
- elastin
- collagen
23
