9.19 Injury, Inflammation, Healing 3 Flashcards Preview

8501 Clin Med > 9.19 Injury, Inflammation, Healing 3 > Flashcards

Flashcards in 9.19 Injury, Inflammation, Healing 3 Deck (23)
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1

goal of tissue healing

restore function if possible

2

What is necessary for tissue return to function?

regeneration

3

tissue regeneration

- not possible in all tissue (neuron, cardiac muscle)
- new research is promising

4

repair of connective tissue

- scarring
- muscle fibrosis

5

repair: maintains integrity of the tissue but does NOT

function as original cells and tissues

6

components that help with the repair process

- fibronectin
- proteoglycan and elastin
- collagen

7

fibronectin

- tensile strength
- glue

8

proteoglycans and elastin

fibroblast proliferation

9

collagen

- fibrous protein
- structural support and tensile strength of tissue

10

What is the most important protein that provides structural support?

collagen

11

Factors that affect healing?

- growth factors
- vascular supply
- age, tissue health, disease, psychological status, alcohol, smoking, nutrition, tissue type, meds, etc.

12

What are the phases of healing?

1. hemostasis and degeneration phase
2. inflammation phase
3. proliferation and migration phase
4. remodeling and maturation phase

13

hemostasis and degeneration phase

- initiation phase
- stops bleeding

14

inflammation phase

prepares for healing

15

proliferation and migration phase

rebuilds and strengthens damaged tissue

16

remodeling and maturation phase

modifies tissue to mature form

17

How is bleeding stopped in the hemostasis and degeneration phase?

- immediately
- coagulation cascade

18

Coagulation cascade involves

- platelets
- growth factors
- proliferation and migration of epithelial cells
- fibroblasts
- vascular endothelial cells

19

What happens during degeneration?

- hematoma formed
- necrosis of dead cells
- inflammatory response of fluid, neutrophils, and macrophages begins

20

degeneration: tissue healing begins within

24 hours

21

degeneration: fibroblast migration

fibroblasts migrate from margins of viable tissue to the defect area

22

Proteins secreted during degeneration phase

- fibronectin
- proteoglycans
- elastin
- collagen

23

What happens between degeneration and inflammation?

proliferation and migration of epidermal cells

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