Flashcards in 9.19 Injury, Inflammation, Healing 3 Deck (23)
goal of tissue healing
restore function if possible
What is necessary for tissue return to function?
- not possible in all tissue (neuron, cardiac muscle)
- new research is promising
repair of connective tissue
- muscle fibrosis
repair: maintains integrity of the tissue but does NOT
function as original cells and tissues
components that help with the repair process
- proteoglycan and elastin
- tensile strength
proteoglycans and elastin
- fibrous protein
- structural support and tensile strength of tissue
What is the most important protein that provides structural support?
Factors that affect healing?
- growth factors
- vascular supply
- age, tissue health, disease, psychological status, alcohol, smoking, nutrition, tissue type, meds, etc.
What are the phases of healing?
1. hemostasis and degeneration phase
2. inflammation phase
3. proliferation and migration phase
4. remodeling and maturation phase
hemostasis and degeneration phase
- initiation phase
- stops bleeding
prepares for healing
proliferation and migration phase
rebuilds and strengthens damaged tissue
remodeling and maturation phase
modifies tissue to mature form
How is bleeding stopped in the hemostasis and degeneration phase?
- coagulation cascade
Coagulation cascade involves
- growth factors
- proliferation and migration of epithelial cells
- vascular endothelial cells
What happens during degeneration?
- hematoma formed
- necrosis of dead cells
- inflammatory response of fluid, neutrophils, and macrophages begins
degeneration: tissue healing begins within
degeneration: fibroblast migration
fibroblasts migrate from margins of viable tissue to the defect area
Proteins secreted during degeneration phase