Viruses/Fungi 7 Flashcards
(22 cards)
How many fungi can cause human infection?
over 200 species
fungi are most problematic in these pts
immunocompromised
systemic antifungal agents are used for
tx of deep (invasive) infections
- Candida
- Cryptococcus
IV systemic antifungal agent
Amphotericin B (Amphocin, Fungizone)
These are better tolerated, but may not be as effective as amphotericin B
Fluconazole (Diflucan)
Diflucan administration
IV or oral
side effects of amphotericin B
- HA
- joint and muscle pain
- fever
- weakness
- GI upset
side effects of Diflucan
- hepatotoxic
- severe skin rxns (S-J syndrome)
- HA
- GI upset
When would a local antifungal be chosen?
when antifungals are too toxic to be administered systemically
Lamisil used for these
- tinea pedis
- tinea cruris
- ringworm
-azole antifungals used for
Candida infections (skin/membranes)
local antifungal agents: side effects
- mild
- usually local
Malaria historically treated with this since the 17th century
quinine
Malaria now treated withy derivatives of this
chloroquine
adverse effects of antiprotozoal drugs
- vary
- GI
- HA
most common protozoan infectious agent
Toxoplasma gondii
Toxoplasma gondii found here
- many animals and birds
- reproduces in cats
- found in cat feces
toxoplasmosis
- flu-like symptoms
- parasites are walled off in cysts in the affected organs
What is a helminth?
parasitic worm
Examples of helminths
- tapeworms
- roundworms
- flukes
helminth route of infection
- ingestion of eggs in contaminated food and water
- eggs hatch
- adult worm lodge in tissue
- steal nutrients from host
Which drugs are used for helminthes?
-azoles
