9.21 Injury, Inflammation, Healing 9 Flashcards Preview

8501 Clin Med > 9.21 Injury, Inflammation, Healing 9 > Flashcards

Flashcards in 9.21 Injury, Inflammation, Healing 9 Deck (21)
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1

Proliferation and migration phase occurs when?

between 2-20 days

2

What occurs during proliferation and migration?

- neovascularization/angiogenesis
- tissue gaps filled
- fibroblasts synthesize collagen, elastin, and proteoglycan cross-links

3

angiogenesis process

- endothelial cells at edge proliferate and establish network
- grounded in connective tissue matrix

4

What causes tissue gaps to be filled in?

- cell migration
- proliferation
- formation of new capillaries

5

newly healing tissue

granulation tissue

6

Type III collagen

initially weak and thin

7

sequence of events with fibroplasia/collagen production

- granulation tissue formed
- Type III collagen
- scar formation
- Type I collagen

8

scar is formed by these

- glycosaminoglycan (GAG)
- collagen

9

Type I collagen forms by day

12

10

Type I collagen

- more mature
- stronger than type III

11

When does the remodeling and maturation phase occur?

Day 9 - 2 years

12

During the remodeling phase, what happens to scar tissue?

- reduced
- remodeled

13

contracture

tissue contracts to pull edges of the wound together

14

Where can excess scar tissue be problematic?

- skin
- joints
- internal organs

15

Why is the usefulness of joint manipulation questionable?

because the "break" takes place at the weakest link

16

How will you know tissue maturation occurs?

- variable
- visible scar will change from vascularized red/pink tissue to less visible skin tone or white

17

There is always the potential to heal any time

a new scar is pink

18

Within just a few hours after skin injury, epithelial cells do this

- flatten out to cover a bare area
- divide and migrate across extracellular matrix to begin regeneration

19

primary intention

- close approximation of tissues
- using sutures

20

secondary intention

indirect union

21

tertiary intention

- contaminated wound
- granulation tissue fills large gap
- slower growth

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